Leaps of Knowledge
DOI:
https://doi.org/10.14738/assrj.115.16972Abstract
Chagas Disease is the main cause of heart failure in the Western Hemisphere. Initially restricted to the American continent, the people's migration to the Northern Hemisphere caused the disease to become present in the five continents. A scientific revolution occurs when an important discovery removes an obstacle to the serial production of new scientific knowledge of social interest. Such a revolution creates a paradigm accepted after experimental analysis and verification by scientists investigating the subject. An example of a leap in knowledge was the discovery of the protozoan Trypanosoma cruzi, its invertebrate and vertebrate hosts, an agent of a new human disease recognized by Dr. Carlos Chagas at the beginning of the twentieth century. Certainly, the seminal work of Carlos Chagas inseminates enthusiasm that is essential to disturb the minds of scientists who produce leaps of knowledge about recondite aspects of Chagas disease at the University of Brasilia.
References
Kropf SKP. Chagas Disease, Brazil Disease. Fiocruz Publishing House, 2009.
Teixeira A. Chagas disease: a science fiction, Editora Kiron, 2017.
Chagas C. New human trypanosomiasis: Studies on the morphology and life cycle of Schizotrypanum cruzi n, gen. Sp. Etiological agent of a new morbid entity in man. Memórias do lnstituto Oswaldo Cruz, 1(2): 159-218, 1911.
Chagas C. New morbid entity of man: general summary of an etiological and clinical study. Memórias do lnstituto Oswaldo Cruz.3(2): 219-275, 1911.
Chagas C. American Trypanosomiasis. Acute form of molesty. Memories of the Oswaldo Cruz lnstitute, 8:37-45, 1916.
Laranja C, Dias E, Nobrega G, Miranda A. Chagas Disease: A Clinical, Epidemiologic, and Pathologic Study. Circulation, 1.035-1060, 1956.
Buch CA, Teixeira ARL, Santos. The immunology of experimental Chagas disease lll: Rejection of allogenic heart cells in vitro. Journal of Experimental Medicine, 140: 38-53, 1974.
Teixeira ARL, Roters F, Mott KE. Acute Chagas disease. Gazeta Médica da Bahia, 3: 170-86, 1970.
Teixeira ARL, Calixto MA, Teixeira ML. Chagas disease: carcinogenic activity of the antitrypanosoma nitroarene in mice. Mutation Research, 305: 189-196, 1994.
Teixeira ARL, Córdoba, JC, Souto-Maior l, Solorzano E. Chagas disease: lymphoma growth in rabbits treated with benznidazole. American Journal of Tropical Medicine Hygiene, 43: 146-158, 1990.
Teixeira ARL, Silva R, Cunha-Neto E, Santana JM, Rizzo LV. Malignant non- Hodgking's lymphoma in Trypanosoma cruzi -infected rabbits treated with nitroarene. Journal of Comparative Pathology, 103: 37-48, 1990.
Lauria-Pires L, Braga MS, Vexenat AC, Nitz N, Simões-Barbosa A, Tinoco DL, Teixeira ARL. Progressive chronic Chagas heart disease ten years after treatment with anti-Trypanosoma cruzi nitro derivatives. American Journal of Tropical Medicine and Hygiene, 63(3-4): 111-8, 2000.
Morillo CA, Marin-Neto J A, Avezum A, Sosa-Estani S, Rassi JR. A Randomized Trial of Benznidazole for Chronic Chagas Cardiomyopathy. New England Journal Medicine, 373: 1295-1306. 2015.
Nitz N, Gomes C, Rosa AC, D'Sousa-Ault M, Moreno F, Lauria-Pires L, Nascimento R J, Teixeira ARL. Heritable integration of kDNA minicircle sequences from Trypanosoma cruzi into the avian genome. lnsights into human Chagas disease. Cell, 118: 175-186, 2004.
Hecht MH, Nitz N, Araujo PF, Sousa AO, Rosa AC, Gomes C, Leonardecz E, Teixeira ARL. lnheritance of DNA Transferred from American Trypanosomes to Human Hosts. PLoS ONE, r (2): e9181, 2010.
Teixeira ARL, Gomes C, Nitz N, Sousa A O, Alves RM, Guimaro MC, Cordeiro C, Bernal FM, Rosa AC, Hejnar J, Leonardecz E, Hecht MM. Trypanosoma cruzi in the chicken model: Chagas-like heart disease in the absence of parasitism. PLoS Neglected Tropical Diseases. 29; 5(3): e1000. 2011.
Teixeira AR, Nitz N, Bernal FM, Hecht MM. Parasite-induced genetically driven autoimmune Chagas heart disease in the chicken model. Journal Visualized. Experiments. 29:3716. Doi: 10.3791/3716. 2012.
Araujo PF, Almeida AB, Pimentel CF, Silva AR, Sousa A, Valente AS. Teixeira ARL. Sexual transmission of American trypanosomiasis in humans: a new potential pandemic route for Chagas parasites. Memórias lnstituto Oswaldo Cruz, Rio de Janeiro, 112 (6): 437-446, 2017.
Almeida AB, Araujo FP, Rosa AC, Valente AS, ARL. Sexual transmission of American trypanosomes from males and females to naive mates. Journal of Visualized Experiments, 2019.
Gomes C, Almeida AB, Rosa AC, Araujo PF, Teixeira ARL. American trypanosomiasis and Chagas disease: Sexual transmission. International Journal of Infectious Diseases, 2019.
Teixeira ARL, Gomes CC, Sá A, Nascimento RJ, Lauria-pires L, Castro AM, Bernal FEM, Sousa AO. Trypanosoma cruzi kDNA minicircle sequences integration into the host genome: a biomarker for monitoring the efficacy of multidrug treatment of Chagas disease. International Journal Scientific Research Updates. 05(01) 170-207, 2023.
Guimaro MC, Alves RM, Rose E, Sousa AO, Rosa AC, Hecht MM, Sousa MV, Andrade RR, Vital T, Plachy J, Nitz N, Hejnar J, Gomes CC, Teixeira ARL. lnhibition of Autoimmune Chagas-Like Heart Disease by Bone Marrow Transplantation. PLoS Neglected Tropical Diseases, 8/12: e3384. 2014.
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