Androgen Insensitivity Syndrome: A Case Report
DOI:
https://doi.org/10.14738/bjhr.1204.19221Keywords:
Androgen insensitivity syndrome, Inguinal testis, Inguinal hernia, Bilateral orchiectomyAbstract
A 22 years old married woman presented with bilateral Inguinal hernia. She gave history of primary amenorrhea and primary infertility. She had well developed breast but scanty pubic hair, no axillary hair and normal looking female external genitalia. Ultra sound revealed absence of uterus, short vagina and bilateral inguinal hernia with inguinal testes. Her Serum testosterone level was elevated. Bilateral orchiectomy and hernia repair was done. Her chromosomal analysis revealed 46 XY. It was confirmed that this was case of Complete variety of Androgen Insensitivity Syndrome (CAIS).
References
Batista RL, Costa EMF, Rodrigues ADS, Gomes NL, Faria JA Jr, Nishi MY et al (2018) Androgen insensitivity syndrome: a review. Arch Endocrinol Metab. 62:227–235
Morris JM. The syndrome of testicular feminization in male pseudohermaphrodites. Am J Obstet Gynecol. 1953;65(6):1192-211.
McPhaul MJ, Marcelli M, Zoppi S, Griffin JE, Wilson JD. Genetic basis of endocrine disease. 4. The spectrum of mutations in the androgen receptor gene that causes androgen resistance. J Clin Endocrinol Metab. 1993;76(1):17-23.
Furdell EL. Midwifery, obstetrics and the rise of gynaecology: the uses of a sixteenth-century compendium. J History Med Allied Sci 2008; 63: 262-4
Dorsey FY, Hsieh MH, Roth DR. 46,XX SRY-negative true hermaphrodite siblings. Urology 2009; 73: 529-31
Brickman AO. Molecular basis of Androgen insensitivity syndrome, AO,Mol Cell Endocrinol. 2001 Jun 20;179(1-2):105-9. doi: 10.1016/s0303-7207(01)00466-x.PMID: 11420135 Review. Islam, S. R., Paul, D., & Sarkar, S. A. (2025). Androgen Insensitivity Syndrome: A Case Report. British Journal of Healthcare and Medical Research, Vol - 12(04). 242-245.
Verkauskas G, Jaubert F, Lortat-Jacob S, Malan V, Thi-baud E, Nihoul-Fékété C. The long-term follow-up of 33 cases of true hermaphroditism: a 40-year experience with conservative gonadal surgery. J Urol 2007; 177: 726-31.
McLean JM. The syndrome of testicular feminization in male pseudohermaphrodites. Am J Obstet Gynecol 1953; 6: 1192-211.
Gulía C, Baldassarra S, Zangari A, et al. Androgen insensitivity syndrome. Eur Rev Med Pharmacol Sci 2018; 22: 3873-87.
Hughes IA, Davies JD, Bunch TI, Pasterski V, Mastroyannopoulou K, MacDougall J. Androgen insensitivity syndrome. Lancet 2012; 380: 1419-28.
Souhail R, Amine S, Nadia A, Tarik K, Khalid EK, Abdellatif K, et al. Complete androgen insensitivity syndrome or testicular feminization: review of literature based on a case report. Pan Afr Med J 2016;25:199.
Hughes IA, Acerini CL. Factors controlling testis descent. Eur J Endocrinol 2008;159 (Suppl 1):S75-82.
Mongan NP, Tadokoro-Cuccaro R, Bunch T, Hughes IA. Androgen insensitivity syndrome. Best Pract Res Clin Endocrinol Metab 2015;29:569-80.
Looijenga LH, Hersmus R, Oosterhuis JW, Cools M, Drop SL, Wolffenbuttel KP. Tumor risk in disorders of sex development (DSD). Best Pract Res Clin Endocrinol Metab 2007;21:480-95.
Heo YJ, Ko JM, Lee YA, Shin CH, Yang SW, Kim MJ, et al. Two girls with complete androgen insensitivity syndrome. Ann Pediatr Endocrinol M
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Sardar Rezaul Islam, Debabrata Paul, Shah Alam Sarkar

This work is licensed under a Creative Commons Attribution 4.0 International License.