Abdominal Sepsis in Surgery and does this "Diagnosis" Really Exist? Effective Surgical Therapy
DOI:
https://doi.org/10.14738/bjhr.1202.18728Keywords:
Abdominal sepsis, Infection, Surgery, Systemic inflammatory response, Chemical peritonitis, Immunological peritonitisAbstract
Introduction: the medical area presents an accelerated advance in knowledge, as well as in technology, which has caused empty gaps that confuse, transcend and are filled or transformed into fiction or unfounded criteria; the specialty of Surgery tends to this phenomenon. Objective: 7 years of experience in the treatment of patients with abdominal sepsis in 3 hospitals. Method: a multicenter, retrospective, longitudinal, observational and descriptive study was conducted to review the records of patients surgically treated for abdominal sepsis over a period of 7 years. Results: 353 patients with abdominal sepsis treated surgically; 243 men (69%), 110 women (31%), with an age range of 18 to 81, mean 42; the first cause is biliary pathology, in 22.94% it does not start with an infectious process, diabetes mellitus occupies the 1st place as comorbidity 39%. Morbidity of 79% and mortality of 23.51%. Discussion: most deaths are caused by the "host response to the infection itself", it is not supported by evidence; this not only skews the science used to model it, but also the approaches to treat it, the accurate diagnosis of infectious diseases is a complex process influenced by factors such as clinical judgment, diagnostic methods and the availability of resources. Conclusions: abdominal sepsis (infectious) does not exist as a real diagnosis, but is an inflammatory process of the individual, complex, multifactorial, where incorrect diagnosis and treatment impact the patient's life. In Mexico, a real situational diagnosis of the health sector must be carried out and a reengineering of processes in the quality of medical-surgical, administrative and research care must be carried out to initiate a beneficial/correct, efficient, effective change in mortality erroneously called abdominal sepsis.
References
Sánchez-González M.A. Historia y futuro de las pandemias. Revista médica clínica los Condes. 2021; 32(1) 7-13.
Perry R.D., Fetherston J.D. Yersinia pestis-etiologic agent of plague. Clin Microbiol Rev. 1997; 10(1):35-66.
Margarita-López M., Cardona-Zorrilla A.F. La peste negra: el enemigo incorpóreo. https://revistamedicina.net/index.php. 2020 e.
Neri-Vela., R. Las enfermedades infecciosas en el hombre y su prevención a lo largo del tiempo. Gaceta médica de México.2021; 157(5): 481-483.
Restrepo M. Anton Van Leeuwenhoek: Breve historia de un descubrimiento. Hechos Microbiol. 2012; 3(2); 99-102.
Sendrail M. Historia cultural de la enfermedad. Madrid: Espasa-Calpe. 1983.
Organización Mundial de la Salud. La OMS publica el primer informe mundial sobre prevención y control de infecciones (PCI). 2022 comunicado de prensa Ginebra. Revisado el 03/04/2025 en: https://www.who.int/es/news/item/06-05-2022-who-launches-first-ever-global-report-on-infectionprevention-and-control
Clínica Universidad de Navarra. Diccionario médico. 2025. Revisado el 03/04/2025 en: https://www.cun.es/diccionario-medico/terminos/infeccion.
Smith D.A., Nehring S.M. Bacteraemia. [Updated July 17, 2023]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; January 2025. Disponible en: https://www.ncbi.nlm.nih.gov/books/NBK441979/ 465
Labbé V., Desnos C., Preau S., et al. Risk, rate or rhythm control for new onset supraventricular arrhythmia during septic shock: protocol for the CAFS multicentre, parallel-group, open-label trial. BMJ Open. 2025; 15(4):e090404.
Sun Q., Teng R., Shi Q et al. Clinical implement of Probe-Capture Metagenomics in sepsis patients: A multicentre and prospective study. Clin Transl Med. 2025; 15(4):e70297.
Nemati A., Gigliucci F., Morabito S., Badouei M.A. Virulence plasmids in edema disease: Insights from wholegenome analysis of porcine O139:H1 Shiga toxin-producing Escherichia coli (STEC) strains. Front Cell Infect Microbiol. 2025; 15:1528408.
Andreu A. Patogenia de las infecciones del tracto urinario. Enfermedades Infecciosas y MicrobiologÃ-a ClÃ-nica. Revisado e04/04/2025 en: https://www.elsevier.es/es-revista-enfermedades-infecciosasmicrobiologia-clinica-28-articulo-patogenia-infecciones-del-tracto-urinario-13091444
Werter D.E., Schneeberger C., Geerlings S.E., et al. Diagnostic Accuracy of Urine Dipsticks for Urinary Tract Infection Diagnosis during Pregnancy: A Retrospective Cohort Study. Antibiotics (Basel). 2024; 13(6):567.
Jd J.M.A., Ramalingam R. Clinicomycological Profile of Dermatophytosis in a Tertiary Care Hospital in Tamil Nadu, India. Cureus. 2025; 17(3):e79961.
Dvorak J., Fojtík L., Adámková L., et al. Proof-of-concept MALDI-TOF-MS assay for the detection of Toxin B enzymatic activity in Clostridioides difficile infection. Microbiol Spectr. 2025: e0245324.
Fang Y., Xie P., Zhang X., et al. Rapid detection of Mycoplasma pneumoniae CARDS toxin in clinical respiratory specimens by a loop-mediated isothermal amplification assay. Front Cell Infect Microbiol. 2025; 15:1496829.
Flores-Medina P. J., Garabay-Murillo P., Peñaloza Mendoza G. R. Automatización de inoculación en medios de cultivo para el laboratorio de microbiología. Rev. Cienc. Tecnol. 2023; 6(4), e285.
Carvalho N., Pereira A., Castro M., et al. Beyond the Lungs: A Case Report of Disseminated Tuberculosis With Multisystem Involvement. Cureus. 2025; 17(2):e78484.
Adu O.F., Sempere Borau M., Früh S.P., et al. Cell binding, uptake, and infection of influenza A virus using recombinant antibody-based receptors. J Virol. 2025: e0227524.
Varadan A.C., Grasis J.A. Filamentous bacteriophage M13 induces proinflammatory responses in intestinal epithelial cells. Infect Immun. 2025: e0061824.
Omosa-Manyonyi G.S., Ponce I.R., Rosati D., et al. Genetic susceptibility to recurrent vulvovaginal candidiasis in an African population from Nairobi, Kenya. Sci Rep. 2025; 15(1):12149.
Al Fadhli A.H., Jamal W.Y., Khodakhast F.B., et al. Salmonella enterica serotypes causing infection in Kuwait during 2018-2021, determined by multi-locus sequence typing or whole genome sequencing. Microbiol Spectr. 2025: e0224824.
Sáenz-Romero L.A., García-Sánchez M.A., Barrera-Zavala A., et al. A Difficult Diagnosis. Journal of biomedical engineeringand medical imaging. 2020; 8(6): 1-5.
Lupio. G. B. R., García-Sánchez. M. A., Atzimba, Z. C. C., et al. Open Abdomen Is the Equal of Catastrophic or Hostile? British Journal of Healthcare and Medical Research. 2024: 11(2):182-200.
Herrera-Medina J.M., Retana-Márquez F.J., García-Sánchez M.A., y cols. Experiencia del tratamiento de la apendicitis aguda. Revista Ocronos. 2024;7(5): 982.7
Alverdy J. Unpacking the sepsis controversy. Trauma Surg Acute Care Open. 2025; 10(1):e001733. doi:
Singer M., Deutschman C.S., Seymour C.W., et al. Third International Consensus on Definitions of Sepsis and Septic Shock (Sepsis-3). JAMA. 2016; 315:801–810.
Mellhammar L., Wollter E., Dahlberg J., et al. Estimating Sepsis Incidence Using Administrative Data and Clinical Medical Record Review. JAMA Netw Open. 2023;6:e2331168.
Lindell R.B., Meyer N.J. Interrogating the sepsis host immune response using cytomics. Crit Care 2023;27:93.
Jaramillo-Bustamante JC, Piñeres-Olave BE, González-Dambrauskas S. SIRS or not SIRS: Is that the infection? A critical review of the sepsis definition criteria. Bol Med Hosp Infant Mex 2020;77:293–302.
Andrews M.C., Duong C.P.M., Gopalakrishnan V., et al. Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockades. Nat Med 2021;27:1432–41.
Thomas R.M., Jobin C. Microbiota in pancreatic health and disease: the next frontier in microbiome research. Nat Rev Gastroenterol Hepatol 2020;17:53–64.
Cassini Alessandro, et al. "Global Report on the epidemiology and burden on sepsis: current evidence, identifying gaps and future directions." Global Report on the epidemiology and burden on sepsis: current evidence, identifying gaps and future directions. 2020.
Vakkalanka J.P., Harland K.K., Swanson M.B., et al. Clinical and epidemiological variability in severe sepsis: an ecological study J Epidemiol Community Health 2018; 72: 741-745.
Parolini C. Sepsis and high-density lipoproteins: Pathophysiology and potential new therapeutic targets. Biochim Biophys Acta Mol Basis Dis. 2025; 1871(5):167761.
Cavaillon J., Marc Adib-Conquy, M., Fitting, C., et al. Cytokine cascade in sepsis. Scandinavian Journal of Infectious Diseases. 2003;35 (9), 535–544.
Schnab B., Brenner D.A. Interactions Between the Intestinal Microbiome and Liver Diseases. Gastroenterology. 2014; 146(6):1513-1524,
Eshaghi S, Sheybani F, Hedjazi A, Naderi H, Shirazinia M, Morovatdar N. Infectious Causes of Death: An Autopsy-Based Study of 546 Cases. Open Forum Infect Dis. 2025 Feb 4;12(2):ofaf065. doi: 10.1093/ofid/ofaf065. PMID: 39963699; PMCID: PMC11832044.
Suneja M., Beekmann S.E., Dhaliwal G., et al. Diagnostic delays in infectious diseases. Diagnosis (Berl). 2022;
Idensohn P.J., Gilbert K., Boodhoo K., et al. The Prevalence, aetiology and Healing Trajectories of Hard-To-Heal Wounds in South Africa. Int Wound J. 2025; 22(3):e70155.
Falsey A., Peterson D., Walsh E., et al. A Four-Gene Signature from Blood to Exclude Bacterial Etiology of Lower Respiratory Tract Infection in Adults. Res Sq [Preprint]. 2025 Feb 27:rs.3.rs-6033997. doi: 10.21203/rs.3.rs-6033997/v1.
Bennett N., Tanamas S.K., James R., et al . Healthcare-associated infections in long-term care facilities: a systematic review and meta-analysis of point prevalence studies. BMJ Public Health. 2024;2(1):e000504. doi: 10.1136/bmjph-2023-000504.
Gurguí M., Moreno A., y cols. Peritonitis y otras infecciones intrabdominales. Sociedad Española de Enfermedades Infecciosas y Microbiología. 2023. Guía de práctica clínica. Madrid, España.
Adeleke A.A., Wuraola F.O., Olasehinde O. Effect of Wound Irrigation with Povidone Iodine Versus Normal Saline on Superficial Incisional Surgical Site Infection Following Laparotomy for Peritonitis. J West Afr Coll Surg. 2025; 15(2):203-208.
Ikota M., Akahoshi T., Murata I., et al. [Perforation of Small Intestinal Gastrointestinal Stromal Tumor Required Emergency Surgery-A Case Report]. Gan To Kagaku Ryoho. 2025; 52(2):182-184.
García Sánchez M.A., Sáenz Romero L.A., De La Fuente González M., et al. Pneumoperitoneum! Is it a Diagnosis? EC Gastroenterology and Digestive System. 2021;8(1): 33-38.
García-Basulto M.J., García-Rodríguez M.E., Benavidez-Márquez A., y cols. Pacientes con infección intrabdominal en la unidad de cuidados intensivos. Revista Cubana de Cirugía. 2020; 59(3).
Dierikx T.H., Admiraal J, Nusman C.M., et al. The diagnostic accuracy of presepsin for late-onset neonatal sepsis: a multicenter prospective cohort study. Pediatr Res. 2025. doi: 10.1038/s41390-025-04008-x.
Malekzadeh M., Khadivi Y., Sohrevardi S.M., Afzal G. Drug prescription patterns and compliance with WHO and beers criteria in older patients. BMC Geriatr. 2025; 25(1):135.
Abdu N., Idrisnur S, Tewelde T., Tesfamariam E.H. Antibiotic prescribing practice using WHO Access, Watch and Reserve classification and its determinants among outpatient prescriptions dispensed to elderly population in six community chain pharmacies in Asmara, Eritrea: a cross-sectional study. BMJ Open. 2024; 14(6):e085743.
Murray K., Shimabukuro J., Khalfay N., et al. Antibiotic Overprescription for "Urinary Tract Infections" Is Associated With Poor Diagnostic Stewardship and Low Adherence to Guidelines. Neurourol Urodyn. 2025;
Hendrix A., Kammien A., Maung A.A., et al. Antibiotics and Surgically Treated Acute Appendicitis, When, Where, and Why? Surg Infect (Larchmt). 2025. doi: 10.1089/sur.2024.264.
Gallego-Navarro C., Beckermann J., Linnaus M.E., et al. Optimizing Antibiotic Management for Adult Patients Presenting with Acute Perforated Appendicitis: A Quality Improvement Study. Surg Infect (Larchmt). 2025;
Droogh D.H.M., de Boer M.G.J., van Prehn J., et al. Dutch Pancreatic Cancer Group. Standard versus Preemptive Antibiotic Treatment to Reduce the Rate of Infectious Outcomes after Whipple resection (SPARROW): a study protocol for a multicentre, open label, randomised controlled trial. Trials. 2025; 26(1):88.
Coccolini F., Brogi E., Ceresoli M., et al. Epidemiological analysis of intra-abdominal infections in Italy from the Italian register of complicated intra-abdominal infections-the IRIS study: a prospective observational nationwide study. World J Emerg Surg. 2025; 20(1):22.
Lang Y., Chen L., Xiao J., et al. A single-center retrospective study of pathogen distribution and antibiotic resistance of bloodstream infections in emergency department. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2024; 49(11):1799-1807.
Kato H., Hirai J., Takano T., et al. A systematic review and meta-analysis on the efficacy of carbapenems versus metronidazole combination therapy in patients infected with Bacteroides spp. J Infect Chemother. 2025; 31(5):102687.
Wang S., Niu W., Lv T., Xie K. Traceability of septic shock caused by phocaeicola vulgatus: a rare case report. BMC Infect Dis. 2025; 25(1):364.
Zhang H., Xia Y., Wang L., Zhang B. Septicemia caused by Eikenella corrodens in a previously healthy male: A case report. Medicine (Baltimore). 2025; 104(13): e41849.
Rubio-García J.J., Mauri Barberá F., Villodre Tudela C., et al. Failure to rescue in colon surgery. J Healthc Qual Res. 2025; 40(4):101118.
García-Sánchez M.A., García-Hernández J.L., Urbina-Cabello J.J., et al. Damage Control Surgery: A Strategic Resource! British Journal of Healthcare and Medical Research 2025; 12, (02): 90-109.
Theobald V., Bloos F., Bauer M., et al. Host-derived Delta-like Canonical Notch ligand-1 in sepsis and septic shock: Infection site, pathogens and disease severity matter - Secondary analysis of data from a randomized controlled trial. J Infect. 2025; 90(4):106458.
Tao T., Shi Y., Ye X., et al. Intraoperative Low-Dose Glucocorticoids in Surgical Patients with Abdominal Sepsis: A Multicenter Retrospective Cohort Study. Health Sci Rep. 2025; 8(2): e70360. doi: 10.1002/hsr2.70360. PMID: 39980824; PMCID: PMC11839392.
Annane D., Renault A., Brun-Buisson C., et al. CRICS-TRIGGERSEP Network. Hydrocortisone plus Fludrocortisone for Adults with Septic Shock. N Engl J Med. 2018 Mar 1;378(9):809-818.
Venkatesh B., Finfer S., Cohen J. et al. ADRENAL Trial Investigators and the Australian–New Zealand Intensive Care Society Clinical Trials Group. Adjunctive Glucocorticoid Therapy in Patients with Septic Shock. N Engl J Med. 2018; 378(9):797-808.
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Copyright (c) 2025 José Luis García Hernández, Morelos Adolfo García Sánchez, Gema Méndez Barrón, Ivonne Alondra León Suárez, José de Jesús Urbina Cabello

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