Exploring the Therapeutic Effects of Noninvasive Brain Stimulation on Motor Function, Cognition, and Quality of Life in Parkinson's Disease: A Systematic Review
DOI:
https://doi.org/10.14738/bjhmr.116.18002Keywords:
Cognition, Brain stimulation, Parkinson's disease, Quality of lifeAbstract
Background: Parkinson's Disease (PD) significantly impacts both cognition and quality of life, posing a substantial burden on patients and healthcare systems. However, there is hope on the horizon. Noninvasive brain stimulation (NIBS) has emerged as a potential therapeutic intervention with the power to mitigate these effects. While the evidence regarding its efficacy remains fragmented, the potential it holds is promising. Objective: The present review explores the effects of noninvasive brain stimulation on cognition and quality of life in patients with Parkinson's disease (PD). Methods: A comprehensive search was carried out in electronic databases to find pertinent articles on noninvasive brain stimulation, such as Transcranial direct stimulation (tDCS) and Transcranial Magnetic Stimulation (TMS), in patients with PD. The methodological quality of the included studies was checked using the PEDro scale. Results: A total of 11 studies were finally included in the studies published between 2012 and 2023. Results indicated that a complex relationship exists between cognition and noninvasive brain stimulation. Additionally, possible therapeutic benefits apart from cognition were identified when examining the quality of life in patients with PD. Conclusion: The present review highlights the complex relationship between quality of life and cognitive functioning. In addition, it summarizes the studies performed on noninvasive brain stimulation in PD. These therapies also proved potent in improving general well-being and cognitive domains. More research is needed to determine the best procedures and interventions with suitable therapeutic outcomes.
References
Ou Z, Pan J, Tang S, Duan D, Yu D, Nong H, et al. Global Trends in the Incidence, Prevalence, and Years Lived with Disability of Parkinson's Disease in 204 Countries/Territories From 1990 to 2019. Front Public Health. 2021;9:776847.
Magrinelli F, Picelli A, Tocco P, Federico A, Roncari L, Smania N, et al. Pathophysiology of Motor Dysfunction in Parkinson's Disease as the Rationale for Drug Treatment and Rehabilitation. Parkinson's Disease. 2016;2016:1–18.
Sanches C, Stengel C, Godard J, Mertz J, Teichmann M, Migliaccio R, et al. Past, Present, and Future of Noninvasive Brain Stimulation Approaches to Treat Cognitive Impairment in Neurodegenerative Diseases: Time for a Comprehensive Critical Review. Front Aging Neurosci. 2021;12:578339.
Zhao H, Qiao L, Fan D, Zhang S, Turel O, Li Y, et al. Modulation of Brain Activity with Noninvasive Transcranial Direct Current Stimulation (tDCS): Clinical Applications and Safety Concerns. Front Psychol. 2017;8:685.
Lau C, Liu M, Chang K, Chang A, Bai C, Tseng C, et al. Effect of single‐session transcranial direct current stimulation on cognition in Parkinson's disease. CNS Neurosci Ther. 2019;25:1237–43.
DeMaagd G, Philip A. Parkinson's Disease and Its Management: Part 1: Disease Entity, Risk Factors, Pathophysiology, Clinical Presentation, and Diagnosis. P T. 2015;40:504–32.
Benninger DH, Lomarev M, Lopez G, Wassermann EM, Li X, Considine E, et al. Transcranial direct current stimulation for the treatment of Parkinson's disease. Journal of Neurology, Neurosurgery & Psychiatry. 2010;81:1105–11.
Callan D, Perrey S. The Use of tDCS and rTMS Methods in Neuroergonomics. Neuroergonomics [Internet]. Elsevier; 2019 [cited 2024 Jan 3]. p. 31–3. Available from: https://linkinghub.elsevier.com/retrieve/pii/B9780128119266000051
Korai SA, Ranieri F, Di Lazzaro V, Papa M, Cirillo G. Neurobiological After-Effects of Low Intensity Transcranial Electric Stimulation of the Human Nervous System: From Basic Mechanisms to Metaplasticity. Front Neurol. 2021;12:587771.
Fasano A, Mazzoni A, Falotico E. Reaching and Grasping Movements in Parkinson's Disease: A Review. JPD. 2022;12:1083–113.
Schoellmann A, Scholten M, Wasserka B, Govindan RB, Krüger R, Gharabaghi A, et al. Anodal tDCS modulates cortical activity and synchronization in Parkinson's disease depending on motor processing. NeuroImage: Clinical. 2019;22:101689. Alokaily, A. O. (2024). Exploring the Therapeutic Effects of Noninvasive Brain Stimulation on Motor Function, Cognition, and Quality of Life in
Sadler CM, Kami AT, Nantel J, Lommen J, Carlsen AN. Transcranial Direct Current Stimulation Over Motor Areas Improves Reaction Time in Parkinson's Disease. Front Neurol. 2022;13:913517.
Adenzato M, Manenti R, Enrici I, Gobbi E, Brambilla M, Alberici A, et al. Transcranial direct current stimulation enhances theory of mind in Parkinson's disease patients with mild cognitive impairment: a randomized, double-blind, sham-controlled study. Transl Neurodegener. 2019;8:1.
Prehn K, Flöel A. Potentials and limits to enhance cognitive functions in healthy and pathological aging by tDCS. Front Cell Neurosci [Internet]. 2015 [cited 2024 Jan 3];9. Available from: http://journal.frontiersin.org/Article/10.3389/fncel.2015.00355/abstract
Ko EJ, Hong MJ, Choi EJ, Yuk JS, Yum MS, Sung IY. Effect of Anodal Transcranial Direct Current Stimulation Combined With Cognitive Training for Improving Cognition and Language Among Children With Cerebral Palsy With Cognitive Impairment: A Pilot, Randomized, Controlled, Double-Blind, and Clinical Trial. Front Pediatr. 2021;9:713792.
Cucca A, Sharma K, Agarwal S, Feigin AS, Biagioni MC. Tele-monitored tDCS rehabilitation: feasibility, challenges and future perspectives in Parkinson's disease. J NeuroEngineering Rehabil. 2019;16:20.
Tahtis V, Kaski D. Parkinson's disease treatments: focus on transcranial direct current stimulation (tDCS). JPRLS. 2017;Volume 7:55–70.
Ni R, Yuan Y, Yang L, Meng Q, Zhu Y, Zhong Y, et al. Novel Noninvasive Transcranial Electrical Stimulation for Parkinson's Disease. Front Aging Neurosci. 2022;14:880897.
Chail A, Saini R, Bhat P, Srivastava K, Chauhan V. Transcranial magnetic stimulation: A review of its evolution and current applications. Ind Psychiatry J. 2018;27:172.
Cohen OS, Rigbi A, Yahalom G, Warman-Alaluf N, Nitsan Z, Zangen A, et al. Repetitive Deep TMS for Parkinson Disease: A 3-Month Double-Blind, Randomized Sham-Controlled Study. Journal of Clinical Neurophysiology. 2018;35:159–65.
Khedr EM, Mohamed KO, Soliman RK, Hassan AMM, Rothwell JC. The Effect of High-Frequency Repetitive Transcranial Magnetic Stimulation on Advancing Parkinson's Disease With Dysphagia: Double Blind Randomized Clinical Trial. Neurorehabil Neural Repair. 2019;33:442–52.
Shirota Y, Ohtsu H, Hamada M, Enomoto H, Ugawa Y, For the Research Committee on rTMS Treatment of Parkinson's Disease. Supplementary motor area stimulation for Parkinson disease: A randomized controlled study. Neurology. 2013;80:1400–5.
Hamada M, Ugawa Y, Tsuji S. High-frequency rTMS over the supplementary motor area improves bradykinesia in Parkinson's disease: Subanalysis of double-blind sham-controlled study. Journal of the Neurological Sciences. 2009;287:143–6.
Somaa FA, De Graaf TA, Sack AT. Transcranial Magnetic Stimulation in the Treatment of Neurological Diseases. Front Neurol. 2022;13:793253.
Boyd L, Brown KE, Ledwell NM, Neva JL. Use of transcranial magnetic stimulation in the treatment of selected movement disorders. DNND. 2014;133.
Department of Otorhinolaryngology, Health Sciences University, Derince Training and Research Hospital, Kocaeli, Turkey, Selcuk AA. A Guide for Systematic Reviews: PRISMA. Turk Arch Otorhinolaryngol. 2019;57:57–8.
Conceição NR, Gobbi LTB, Nóbrega-Sousa P, Orcioli-Silva D, Beretta VS, Lirani-Silva E, et al. Aerobic Exercise Combined With Transcranial Direct Current Stimulation Over the Prefrontal Cortex in Parkinson Disease: Effects on Cortical Activity, Gait, and Cognition. Neurorehabil Neural Repair. 2021;35:717–28.
Yotnuengnit P, Bhidayasiri R, Donkhan R, Chaluaysrimuang J, Piravej K. Effects of Transcranial Direct Current Stimulation Plus Physical Therapy on Gait in Patients With Parkinson Disease: A Randomized Controlled Trial. American Journal of Physical Medicine & Rehabilitation. 2018;97:7–15.
Yang Y-R, Tseng C-Y, Chiou S-Y, Liao K-K, Cheng S-J, Lai K-L, et al. Combination of rTMS and Treadmill Training Modulates Corticomotor Inhibition and Improves Walking in Parkinson Disease: A Randomized Trial. Neurorehabil Neural Repair. 2013;27:79–86.
Pereira JB, Junqué C, Bartrés-Faz D, Martí MJ, Sala-Llonch R, Compta Y, et al. Modulation of verbal fluency networks by transcranial direct current stimulation (tDCS) in Parkinson's disease. Brain Stimulation. 2013;6:16–24.
Lattari E, Costa SS, Campos C, De Oliveira AJ, Machado S, Maranhao Neto GA. Can transcranial direct current stimulation on the dorsolateral prefrontal cortex improves balance and functional mobility in Parkinson's disease? Neuroscience Letters. 2017;636:165–9.
Holczer A, Vékony T, Klivényi P, Must A. Frontal two-electrode transcranial direct current stimulation protocols may not affect performance on a combined flanker Go/No-Go task. Sci Rep. 2023;13:11901.
Begemann MJ, Brand BA, Ćurčić-Blake B, Aleman A, Sommer IE. Efficacy of noninvasive brain stimulation on cognitive functioning in brain disorders: a meta-analysis. Psychol Med. 2020;50:2465–86.
Palimariciuc M, Oprea DC, Cristofor AC, Florea T, Dobrin RP, Dobrin I, et al. The Effects of Transcranial Direct Current Stimulation in Patients with Mild Cognitive Impairment. Neurology International. 2023;15:1423–42.
Lawrence BJ, Gasson N, Johnson AR, Booth L, Loftus AM. Cognitive Training and Transcranial Direct Current Stimulation for Mild Cognitive Impairment in Parkinson's Disease: A Randomized Controlled Trial. Parkinson's Disease. 2018;2018:1–12.
Manenti R, Cotelli MS, Cobelli C, Gobbi E, Brambilla M, Rusich D, et al. Transcranial direct current stimulation combined with cognitive training for the treatment of Parkinson Disease: A randomized, placebo-controlled study. Brain Stimulation. 2018;11:1251–62.
Costa-Ribeiro A, Andrade SMMDS, Férrer MLV, Silva OAPD, Salvador MLS, Smaili S, et al. Can Task Specificity Impact tDCS-Linked to Dual Task Training Gains in Parkinson's Disease? A Protocol for a Randomized Controlled Trial. Front Aging Neurosci. 2021;13:684689.
Schneider N, Dagan M, Katz R, Thumm PC, Brozgol M, Giladi N, et al. Combining transcranial direct current stimulation with a motor-cognitive task: the impact on dual-task walking costs in older adults. J NeuroEngineering Rehabil. 2021;18:23.
Beheshti I, Ko JH. Modulating brain networks associated with cognitive deficits in Parkinson's disease. Mol Med. 2021;27:24.
Berganzo K, Tijero B, González-Eizaguirre A, Somme J, Lezcano E, Gabilondo I, et al. Síntomas no motores y motores en la enfermedad de Parkinson y su relación con la calidad de vida y los distintos subgrupos clínicos. Neurología. 2016;31:585–91.
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