Diabetic Foot Ulcers Treated with Nanotherapy: A Short Communication
DOI:
https://doi.org/10.14738/bjhmr.115.17493Keywords:
Bionanocatalyst, Foot wounds, Diabetic foot, Venous ulcersAbstract
The current study proposes an innovative approach: the development of a nanotherapeutic particles designed to encompass all the desired functionalities outlined by previous researchers. These include: a) bactericidal properties, b) the ability to generate ROS species from lactic acid when the Krebs cycle deviates to the Cori cycle, c) promotion of angiogenesis and oxygenation of wounds, and d) acting as a catalyst for cell regeneration, thereby facilitating the closure of diabetic foot ulcers. These nanotherapeutic particles are synthesized from an organometallic compound integrated into a polymeric amorphous matrix. Crucially, it is superficially coated with a variety of functional groups, exhibiting a particle size ranging from 1 to 5 nanometers as determined by transmission electron microscopy (TEM), with a specific surface area exceeding 700 m2/g. Preliminary preclinical findings have been documented, and we present additional promising outcomes in this report.
References
Álvaro-Afonso FJ, García-Álvarez Y, Tardáguila-García A, García-Madrid M, López-Moral M, Lázaro-Martínez JL. Bacterial Diversity and Antibiotic Resistance in Patients with Diabetic Foot Osteomyelitis. Antibiotics 2023; 12:212. https://doi.org/10.3390/antibiotics12020212.
Baig MS, Banu A, Zehravi M, Rana R, Burle SS, Khan SL, et al. An Overview of Diabetic Foot Ulcers and Associated Problems with Special Emphasis on Treatments with Antimicrobials. Life 2022; 12:1054. https://doi.org/10.3390/life12071054. 15
Sadeghpour Heravi F, Zakrzewski M, Vickery K, G. Armstrong D, Hu H. Bacterial Diversity of Diabetic Foot Ulcers: Current Status and Future Prospectives. J Clin Med 2019; 8:1935. https://doi.org/10.3390/jcm8111935.
Rodrigues BT, Vangaveti VN, Urkude R, Biros E, Malabu UH. Prevalence and risk factors of lower limb amputations in patients with diabetic foot ulcers: A systematic review and meta-analysis. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 2022; 16:102397. https://doi.org/10.1016/j.dsx.2022.102397.
Chamberlain RC, Fleetwood K, Wild SH, Colhoun HM, Lindsay RS, Petrie JR, et al. Foot Ulcer and Risk of Lower Limb Amputation or Death in People with Diabetes: A National Population-Based Retrospective Cohort Study. Diabetes Care 2022; 45:83–91. https://doi.org/10.2337/dc21-1596.
Anita H, Manoj A, Arunagirinathan N, Rameshkumar MR, Revathi K, Selvam R, et al. Bacterial etiology, antibiotic resistance profile and foot ulcer associated amputations in individuals with Type II diabetes mellitus. J King Saud Univ Sci 2023; 35:102891. https://doi.org/10.1016/j.jksus.2023.102891.
Rayman G, Vas P, Dhatariya K, Driver V, Hartemann A, Londahl M, et al. Guidelines on use of interventions to enhance healing of chronic foot ulcers in diabetes (IWGDF 2019 update). Diabetes Metab Res Rev 2020;36. https://doi.org/10.1002/dmrr.3283.
Loera-Valencia R, Neira RE, Urbina BP, Camacho A, Galindo RB. Evaluation of the therapeutic efficacy of dressings with ZnO nanoparticles in the treatment of diabetic foot ulcers. Biomedicine & Pharmacotherapy 2022; 155:113708. https://doi.org/10.1016/j.biopha.2022.113708.
Choudhury H, Pandey M, Lim YQ, Low CY, Lee CT, Marilyn TCL, et al. Silver nanoparticles: Advanced and promising technology in diabetic wound therapy. Materials Science and Engineering: C 2020; 112:110925. https://doi.org/10.1016/j.msec.2020.110925.
Ahmad SA, Das SS, Khatoon A, Ansari MT, Afzal M, Hasnain MS, et al. Bactericidal activity of silver nanoparticles: A mechanistic review. Mater Sci Energy Technol 2020; 3:756–69. https://doi.org/10.1016/j.mset.2020.09.002.
Yin IX, Zhang J, Zhao IS, Mei ML, Li Q, Chu CH.
The Antibacterial Mechanism of Silver Nanoparticles and Its Application in Dentistry
. Int J Nanomedicine 2020; Volume 15:2555–62. https://doi.org/10.2147/IJN.S246764.Hadrup N, Sharma AK, Loeschner K. Toxicity of silver ions, metallic silver, and silver nanoparticle materials after in vivo dermal and mucosal surface exposure: A review. Regulatory Toxicology and Pharmacology 2018; 98:257–67. https://doi.org/10.1016/j.yrtph.2018.08.007.
Zheng J, Deng Y, Zhao S, Liu L, Wang W, Li J, et al. Cascade-driven nanomotors promote diabetic wound healing by eradicating MRSA biofilm infection. Chemical Engineering Journal 2024; 481:148790. https://doi.org/10.1016/j.cej.2024.148790.
Wang L, Yang Y, Han W, Ding H. Novel design and development of Centella Asiatica extract - loaded poloxamer/ZnO nanocomposite wound closure material to improve anti-bacterial action and enhanced wound healing efficacy in diabetic foot ulcer. Regen Ther 2024; 27:92–103. https://doi.org/10.1016/j.reth.2024.03.006.
El-Salamouni NS, Gowayed MA, Younis SE, Abdel-Bary A, Kamel MA, Labib GS. Pentoxifylline/Valsartan codelivery in liposomal gel alters the inflammatory HMGB-1/ TLR pathway and promotes faster healing in burn wounds: A promising repurposed approach. Int J Pharm 2022; 625:122129. https://doi.org/10.1016/j.ijpharm.2022.122129. 16
She P, Luo Z, Chen L, Wu Y. Efficacy of levofloxacin against biofilms of Pseudomonas aeruginosa isolated from patients with respiratory tract infections in vitro. Microbiologyopen 2019;8. https://doi.org/10.1002/mbo3.720.
Singh M, Thakur V, Kumar V, Raj M, Gupta S, Devi N, et al. Silver Nanoparticles and Its Mechanistic Insight for Chronic Wound Healing: Review on Recent Progress. Molecules 2022; 27:5587. https://doi.org/10.3390/molecules27175587.
López-Goerne TM. Nanotecnología y nanomedicina: la ciencia del futuro… hoy. 1st ed. Mexico City: Arkhé Ediciones; 2011.
López T, Alvarez M, González RD, Uddin MJ, Bustos J, Arroyo S, et al. Synthesis, characterization and in vitro cytotoxicity of Pt-TiO2 nanoparticles. Adsorption 2011 17:3 2011; 17:573–81. https://doi.org/10.1007/S10450-011-9330-X.
Soni KS, Desale SS, Bronich TK. Nanogels: An overview of properties, biomedical applications and obstacles to clinical translation. Journal of Controlled Release 2016; 240:109–26. https://doi.org/10.1016/j.jconrel.2015.11.009.
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Copyright (c) 2024 Tessy Lopez-Goerne, Rafael Valienet, Antonella Gonzalez-Bondani, Francisco J. Padilla-Godínez
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