Involvement of Nitric Oxide in Mitochondrial Activity and Brain Functions
DOI:
https://doi.org/10.14738/bjhmr.112.16833Keywords:
Brain circulation, Nitrite, Mitochondrial function, NADH redox state, Brain ionic homeostasis, Cortical Spreading DepressionAbstract
Nitric Oxide (NO) is a critical regulator of cerebral blood flow as well as in the activity of the respiratory chain in the normal brain. The reduction of nitrate by red blood cells producing NO, plays a role in the regulation of vascular tone. In our study we found that Nitrite infusion increases CBF and decreased m ean arterial pressure. In our study we found that Nitrite has a regulatory role in brain circulation but not in the small intestine. Also, it seems that NO plays an important role in the autoregulation of CBF and mitochondrial function in the partially ischemic brain. Also it was found that NOS inhibitors demonstrate a beneficial on the brain cortex under status epilepticus induced by metrazol, implying that they may serve as anticonvulsant drugs. In the current study we concluded that NO may play a role during the initial phase of cortical spreading depression namely during the depolarization phase.
References
Dawson, T.M. and S.H. Snyder, Gases as biological messengers: nitric oxide and carbon monoxide in the brain. J Neurosci, 1994. 14(9): p. 5147-59.
Snyder, S.H., S.R. Jaffrey, and R. Zakhary, Nitric oxide and carbon monoxide: parallel roles as neural messengers. Brain Res. Brain Res. Rev., 1998. 26(2-3): p. 167-75.
Hartsfield, C.L., Cross talk between carbon monoxide and nitric oxide. Antioxid. Redox Signal, 2002. 4(2): p.
Nowaczyk, A., et al., Carbon Monoxide and Nitric Oxide as Examples of the Youngest Class of Transmitters. Int. J. Mol. Sci., 2021. 22(11).
Baumgart, K., P. Radermacher, and F. Wagner, Applying gases for microcirculatory and cellular oxygenation in sepsis: effects of nitric oxide, carbon monoxide, and hydrogen sulfide. Curr. Opin. Anaesthesiol., 2009.
Pun, P.B., et al., Gases in the mitochondria. Mitochondrion, 2010. 10(2): p. 83-93.
Cooper, C.E. and G.C. Brown, The inhibition of mitochondrial cytochrome oxidase by the gases carbon monoxide, nitric oxide, hydrogen cyanide and hydrogen sulfide: chemical mechanism and physiological significance. J. Bioenerg. Biomembr., 2008. 40(5): p. 533-9.
Thorup, C., et al., Carbon monoxide induces vasodilation and nitric oxide release but suppresses endothelial NOS. Am. J. Physiol., 1999. 277(6): p. F882-9. 249
Rifkind, J.M., et al., Nitrite infusion increases cerebral blood flow and decreases mean arterial blood pressure in rats: A role for red cell NO. Nitric Oxide., 2007. 16: p. 448-456.
Ignarro, L.J., et al., Nitric oxide as a signaling molecule in the vascular system: an overview. J Cardiovasc Pharmacol, 1999. 34(6): p. 879-86.
Nagababu, E., et al., Active nitric oxide produced in the red cell under hypoxic conditions by deoxyhemoglobin-mediated nitrite reduction. J Biol Chem, 2003. 278(47): p. 46349-56.
Cosby, K., et al., Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat Med, 2003. 9(12): p. 1498-505.
Nohl, H., et al., Mitochondria recycle nitrite back to the bioregulator nitric monoxide. Acta Biochim Pol, 2000. 47(4): p. 913-21.
Millar, T.M., et al., Xanthine oxidoreductase catalyses the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions. FEBS Lett, 1998. 427(2): p. 225-8.
Li, H., et al., Characterization of the magnitude and kinetics of xanthine oxidase-catalyzed nitrite reduction. Evaluation of its role in nitric oxide generation in anoxic tissues. J Biol Chem, 2001. 276(27): p. 24482-9.
Boughton-Smith, N.K., et al., Induction of nitric oxide synthase in rat intestine and its association with tissue injury. Agents Actions, 1993. 38 Spec No: p. C125-6.
Crouser, E.D., et al., Endotoxin-induced mitochondrial damage correlates with impaired respiratory activity. Crit Care Med, 2002. 30(2): p. 276-84.
Gutierrez, G., Regional blood flow and oxygen transport: implications for the therapy of the septic patient. Crit Care Med, 1993. 21(9): p. 1263-4.
Maginniss, L.A., et al., Adrenergic vasoconstriction augments tissue O2 extraction during reductions in O2 delivery. J Appl Physiol (1985), 1994. 76(4): p. 1454-61.
Nelson, D.P., et al., Pathological supply dependence of O2 uptake during bacteremia in dogs. J Appl Physiol (1985), 1987. 63(4): p. 1487-92.
Spain, D.A., et al., Role of nitric oxide in the small intestinal microcirculation during bacteremia. Shock, 1994.
Weiss, H.R. and J.A. Cohen, Changes in small vessel blood content of the rat heart induced by hypercapnic, hyperoxic or asphyxic conditions. Cardiology, 1978. 63(4): p. 199-207.
Hershey, J.C. and R.F. Bond, Oxygen extraction and vascular dilation are dependently increased in skeletal muscle during canine endotoxemia. Circ Shock, 1993. 40(2): p. 132-8.
Lubbe, A.S., et al., EDRF as a possible mediator of sepsis-induced arteriolar dilation in skeletal muscle. Am J Physiol, 1992. 262(3 Pt 2): p. H880-7.
Revelly, J.P., et al., Endotoxic shock alters distribution of blood flow within the intestinal wall. Crit Care Med, 1996. 24(8): p. 1345-51.
Vallet, B., et al., Gut and muscle tissue PO2 in endotoxemic dogs during shock and resuscitation. J Appl Physiol (1985), 1994. 76(2): p. 793-800.
Tolmasov, M., E. Barbiro-Michaely, and A. Mayevsky, The involvement of nitric oxide in the hemodynamic and metabolic activities of the brain and small intestine, in SPIE BiOS: Biomedical Optics, A. Mahadevan- 250 Mayevsky, A. (2024). Involvement of Nitric Oxide in Mitochondrial Activity and Brain Functions. British Journal of Healthcare and Medical Research, Jansen, T. Vo-Dinh, and W.S. Grundfest, Editors. 2009, International Society for Optics and Photonics. p. 716906-716906-7.
Kader, A., et al., Nitric oxide production during focal cerebral ischemia in rats. Stroke, 1993. 24(11): p. 1709-16.
Macrae, I.M., et al., Inhibition of nitric oxide synthesis: effects on cerebral blood flow and glucose utilisation in the rat. J Cereb Blood Flow Metab, 1993. 13(6): p. 985-92.
Brown, G.C., Cell biology. NO says yes to mitochondria. Science, 2003. 299(5608): p. 838-9.
Bolanos, J.P. and A. Almeida, Nitric Oxide in Regulation 7 ס Mitochondrial Function, Respiration, and Glycolysis, in Handbook of Neurochemistry and Molecular Neurobiology, A. Lajtha, G.E. Gibson, and G.A. Dienel, Editors. 2007, Springer: US. p. 487-517.
Buerk, D.G., Nitric oxide regulation of microvascular oxygen. Antioxid Redox Signal, 2007. 9(7): p. 829-43.
Gursoy-Ozdemir, Y., et al., Role of endothelial nitric oxide generation and peroxynitrite formation in reperfusion injury after focal cerebral ischemia. Stroke, 2000. 31(8): p. 1974-80; discussion 1981.
Rao, A.M., et al., Fluorometric assay of nitrite and nitrate in brain tissue after traumatic brain injury and cerebral ischemia. Brain Res, 1998. 793(1-2): p. 265-70.
Bolanos, J.P. and A. Almeida, Roles of nitric oxide in brain hypoxia-ischemia. Biochim Biophys Acta, 1999. 1411(2-3): p. 415-36.
Faraci, F.M. and D.D. Heistad, Regulation of the cerebral circulation: role of endothelium and potassium channels. Physiol Rev, 1998. 78(1): p. 53-97.
Zhang, J., et al., Nitric oxide synthase inhibition and extracellular glutamate concentration after cerebral ischemia/reperfusion. Stroke, 1995. 26(2): p. 298-304.
Danielisova, V., M. Nemethova, and J. Burda, The protective effect of aminoguanidine on cerebral ischemic damage in the rat brain. Physiol Res, 2004. 53(5): p. 533-40.
Jung, K.H., et al., Early intravenous infusion of sodium nitrite protects brain against in vivo ischemiareperfusion injury. Stroke, 2006. 37(11): p. 2744-50.
Dezfulian, C., et al., Role of the anion nitrite in ischemia-reperfusion cytoprotection and therapeutics. Cardiovasc Res, 2007. 75(2): p. 327-38.
Friedli, C.M., D.S. Sclarsky, and A. Mayevsky, Multiprobe monitoring of ionic, metabolic, and electrical activities in the awake brain. Am. J. Physiol., 1982. 243(3): p. R462-9.
Eibeshitz, E., E. Barbiro-Michaely, and A. Mayevsky. The role of nitric oxide in the ischemic brain evaluated by spectroscopic monitoring of mitochondrial NADH, microcirculatory blood flow, and HbO. in Photonics and Optoelectronics Meetings. 2008. International Society for Optics and Photonics.
Rampil, I.J., L. Litt, and A. Mayevsky, Correlated, simultaneous, multiple-wavelength optical monitoring in vivo of localized cerebrocortical NADH and brain microvessel hemoglobin oxygen saturation. J. Clin. Monit., 1992. 8(3): p. 216-225.
Tonnesen, J., et al., Laser Doppler flowmetry is valid for measurement of cerebral blood flow autoregulation lower limit in rats. Exp Physiol, 2005. 90(3): p. 349-55.
Mayevsky, A., et al., Real-time optical monitoring of tissue vitality in vivo. Proceeding of SPIE, 2002. 4616: p.
Leão, A.A.P., Spreading depression of activity in cerebral cortex. J. Neurophysiol., 1944. 7: p. 359-390.
Vyskocil, F., N. Kritz, and J. Bures, Potassium-selective microelectrodes used for measuring the extracellular brain potassium during spreading depression and anoxic depolarization in rats. Brain Res., 1972. 39(1): p.
Mayevsky, A. and H.R. Weiss, Cerebral blood flow and oxygen consumption in cortical spreading depression. J. CBF Metab., 1991. 11: p. 829-836.
Mayevsky, A., T. Zeuthen, and B. Chance, Measurements of extracellular potassium, ECoG and pyridine nucleotide levels during cortical spreading depression in rats. Brain Res., 1974. 76: p. 347-349.
Bures, J., O. Buresova, and J. Krivanek, The Mechanism and Applications of Leão’s Spreading Depression of Electroencephalographic Activity. 1974, New York: Academic.
Hansen, A.J., Effect of anoxia on ion distribution in the brain. Physiol Rev, 1985. 65: p. 101-148.
Leão, A.A.P., Pial circulation and spreading depression of activity in the cerebral cortex. J. Neurophysiol., 1944. 7: p. 391-396.
Van Harreveld, A. and S. Ochs, Electrical and vascular concomitants of spreading depression. Am. J. Physiol., 1957. 189(1): p. 159-66.
Van Harreveld, A. and J.S. Stamm, Vascular concomitants of spreading cortical depression. J. Neurophysiol., 1952. 15(6): p. 487-96.
Buresova, O., Changes in cerebral circulationin rats during spreading EEG depression. Physiol. Bohemoslovenica, 1957. 6: p. 1-11.
Hansen, A.J., B. Quistorff, and A. Gjedde, Relationship between local changes in cortical blood flow and extracellular K+ during spreading depression. Acta Physiol. Scand., 1980. 109(1): p. 1-6.
Mies, G. and W. Paschen, Regional changes of blood flow, glucose, and ATP content determined on brain sections during a single passage of spreading depression in rat brain cortex. Exp. Neurol., 1984. 84(2): p.
Lauritzen, M., Long-lasting reduction of cortical blood flow of the brain after spreading depression with preserved autoregulation and impaired CO2 response. J. Cereb. Blood Flow Metab., 1984. 4(4): p. 546-54.
Lauritzen, M., et al., Persistent oligemia of rat cerebral cortex in the wake of spreading depression. Ann. Neurol., 1982. 12(5): p. 469-74.
Lauritzen, M., Regional cerebral blood flow during cortical spreading depression in rat brain: increased reactive hyperperfusion in low-flow states. Acta Neurol. Scand., 1987. 75(1): p. 1-8.
Lauritzen, M., Cerebral blood flow in migraine and cortical spreading depression. Acta Neurol. Scand. Suppl., 1987. 113: p. 1-40.
Meilin, S., et al., Multiparametric responses to cortical spreading depression under nitric oxide synthesis inhibition, in Biochemical Pharmacological and Clinical Aspects of Nitric Oxide, B.A. Weissman, N. Alon, and S. Shapira, Editors. 1995, Plenum Press: New York. p. 195-204. Mayevsky, A. (2024). Involvement of Nitric Oxide in Mitochondrial Activity and Brain Functions. British Journal of Healthcare and Medical Research,
Duckrow, R.B., A brief hypoperfusion precedes spreading depression if nitric oxide synthesis is inhibited. Brain Res., 1993. 618(2): p. 190-5.
Goadsby, P.J., H. Kaube, and K.L. Hoskin, Nitric oxide synthesis couples cerebral blood flow and metabolism. Brain Res., 1992. 595(1): p. 167-70.
Iadecola, C., et al., Nitric oxide synthase inhibition and cerebrovascular regulation. J. Cereb. Blood Flow Metab., 1994. 14(2): p. 175-92.
Irikura, K., K.I. Maynard, and M.A. Moskowitz, Importance of nitric oxide synthase inhibition to the attenuated vascular responses induced by topical L-nitroarginine during vibrissal stimulation. J. Cereb. Blood Flow Metab., 1994. 14(1): p. 45-8.
Culotta, E. and D.E. Koshland, Jr., NO news is good news. Science, 1992. 258(5090): p. 1862-5.
Mayevsky, A., et al., Multiparametric evaluation of brain functions in the Mongolian gerbil in vivo. J. Basic Clin. Physiol. Pharmacol., 1992. 3: p. 323-342.
De Sarro, G.B., et al., Role of nitric oxide in the genesis of excitatory amino acid-induced seizures from the deep prepiriform cortex. Fundam Clin Pharmacol, 1991. 5(6): p. 503-11.
Fedele, E. and M. Raiteri, In vivo studies of the cerebral glutamate receptor/NO/cGMP pathway. Prog Neurobiol, 1999. 58(1): p. 89-120.
Snyder, S.H., Nitric oxide: first in a new class of neurotransmitters. Science, 1992. 257(5069): p. 494-6.
Hosseinzadeh, H., G.R. Karimi, and M. Rakhshanizadeh, Anticonvulsant effect of Hypericum perforatum: role of nitric oxide. J Ethnopharmacol, 2005. 98(1-2): p. 207-8.
Lancelot, E., et al., Glutamate induces hydroxyl radical formation in vivo via activation of nitric oxide synthase in Sprague-Dawley rats. Neurosci Lett, 1998. 242(3): p. 131-4.
Lei, S.Z., et al., Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex. Neuron, 1992. 8(6): p. 1087-99.
Manzoni, O., et al., Nitric oxide-induced blockade of NMDA receptors. Neuron, 1992. 8(4): p. 653-62.
Rifkind, J.M., E. Nagababu, and S. Ramasamy, Nitric oxide redox reactions and red cell biology. Antioxid Redox Signal, 2006. 8(7-8): p. 1193-203.
Barbiro-Michaely, E., A. Mendelman, and A. Mayevsky, The evaluation of nitric oxide involvement in metrazol induced status epilepticus using multiparametric monitoring. Brain research, 2011. 1377: p. 50-9.
Nagababu, E., S. Ramasamy, and J.M. Rifkind, S-nitrosohemoglobin: a mechanism for its formation in conjunction with nitrite reduction by deoxyhemoglobin. Nitric Oxide, 2006. 15(1): p. 20-9.
Dejam, A., et al., Erythrocytes are the major intravascular storage sites of nitrite in human blood. Blood, 2005. 106(2): p. 734-9.
Klimmek, R., et al., Effects of 4-dimethylaminophenol, CO2EDTA, or NaNO2 on cerebral blood flow and sinus blood homeostasis of dogs in connection with acute cyanide poisoning. Toxicology, 1983. 26(2): p. 143-54.
Klimmek, R., C. Roddewig, and N. Weger, Effects of 4-dimethylaminophenol on blood flow and blood gases in the brain. Res Exp Med (Berl), 1981. 179(2): p. 141-51.
Reutov, V.P. and E.G. Sorokina, NO-synthase and nitrite-reductase components of nitric oxide cycle. Biochemistry (Mosc), 1998. 63(7): p. 874-84.
Wolak, M., et al., Kinetics and mechanism of the reversible binding of nitric oxide to reduced cobalamin B(12r) (Cob (II)alamin). J Am Chem Soc, 2001. 123(40): p. 9780-91.
Huang, Z., et al., Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control. J Clin Invest, 2005. 115(8): p. 2099-107.
Zweier, J.L., et al., Enzyme-independent formation of nitric oxide in biological tissues. Nat Med, 1995. 1(8): p.
Licker, M., et al., Role of nitric oxide in the regulation of regional blood flow and metabolism in anaesthetized pigs. Acta Physiol Scand, 1998. 163(4): p. 339-48.
Ye, S., S. Nosrati, and V.M. Campese, Nitric oxide (NO) modulates the neurogenic control of blood pressure in rats with chronic renal failure (CRF). J Clin Invest, 1997. 99(3): p. 540-8.
Tsuchiya, K., et al., Nitrite is an alternative source of NO in vivo. Am J Physiol Heart Circ Physiol, 2005. 288(5): p. H2163-70.
Kohn, M.C., et al., Pharmacokinetics of sodium nitrite-induced methemoglobinemia in the rat. Drug Metab Dispos, 2002. 30(6): p. 676-83.
Kobari, M., et al., Role of nitric oxide in regulation of cerebral microvascular tone and autoregulation of cerebral blood flow in cats. Brain Res, 1994. 667(2): p. 255-62.
Piantadosi, C.A., Carbo ח monoxide, oxygen transport and oxygen metabolism. J. l-lypebaric Med, 1987. 2: p.
Buerk, D.G., Can we model nitric oxide biotransport? A survey of mathematical models for a simple diatomic molecule with surprisingly complex biological activities. Annu Rev Biomed Eng, 2001. 3: p. 109-43.
Brown, G.C., Nitric oxide and mitochondria. Front Biosci, 2007. 12: p. 1024-33.
Palacios-Callender, M., et al., Cytochrome c oxidase maintains mitochondrial respiration during partial inhibition by nitric oxide. J Cell Sci, 2007. 120(Pt 1): p. 160-5.
Castillo, C., et al., Thiopental inhibits nitric oxide production in rat aorta. Can J Physiol Pharmacol, 1999.
Miyawaki, I., et al., Modification of endothelium-dependent relaxation by propofol, ketamine, and midazolam. Anesth Analg, 1995. 81(3): p. 474-9.
Blaise, G., et al., Does halothane interfere with the release, action, or stability of endothelium-derived relaxing factor/nitric oxide? Anesthesiology, 1994. 80(2): p. 417-26.
Takahashi, S., et al., Preservation of autoregulatory cerebral vasodilator responses to hypotension after inhibition of nitric oxide synthesis. Brain Res, 1995. 678(1-2): p. 21-8.
Buchanan, J.E. and J.W. Phillis, The role of nitric oxide in the regulation of cerebral blood flow. Brain Res, 1993. 610(2): p. 248-55.
Kelly, P.A., et al., Cerebrovascular autoregulation in response to hypertension induced by NG-nitro-L-arginine methyl ester. Neuroscience, 1994. 59(1): p. 13-20. 254 Mayevsky, A. (2024). Involvement of Nitric Oxide in Mitochondrial Activity and Brain Functions. British Journal of Healthcare and Medical Research,
Mayevsky, A., N. Zarchin, and J. Sonn, Brain redox state and O2 balance in experimental spreading depression and ischemia, in Migraine - Basic Mechanisms and Treatment A. Lehmenkuhler, K.-H. Grotemeyer, and F. Tegtmeier, Editors. 1993, Urban & Schwarzenberg: Munchen-Wier, Baltimore. p. 379-393.
Schaller, B., [Craniocerebral trauma--new pathophysiological and therapeutic viewpoints. 1: Management of the acute phase]. Swiss Surg., 2002. 8(3): p. 123-37.
Vleeming, W., et al., Effect of nitrite on blood pressure in anaesthetized and free-moving rats. Food Chem Toxicol, 1997. 35(6): p. 615-9.
De Ley, G., J.B. Nshimyumuremyi, and I. Leusen, Hemispheric blood flow in the rat after unilateral common carotid occlusion: evolution with time. Stroke, 1985. 16(1): p. 69-73.
McCarron, R.M., et al., Endothelial-mediated regulation of cerebral microcirculation. J Physiol Pharmacol, 2006. 57 Suppl 11: p. 133-44.
Choi, I.Y., H. Lei, and R. Gruetter, Effect of deep pentobarbital anesthesia on neurotransmitter metabolism in vivo: on the correlation of total glucose consumption with glutamatergic action. J Cereb Blood Flow Metab, 2002. 22(11): p. 1343-51.
Hyder, F., et al., Dependence of oxygen delivery on blood flow in rat brain: a 7-tesla nuclear magnetic resonance study. J Cereb Blood Flow Metab, 2000. 20(3): p. 485-98.
Chen, S.H. and R.T. Cheung, Neuropeptide Y and its receptor analogs differentially modulate the immunoreactivity for neuronal or endothelial nitric oxide synthase in the rat brain following focal ischemia with reperfusion. J Biomed Sci, 2005. 12(2): p. 267-78.
Stewart, V.C. and S.J. Heales, Nitric oxide-induced mitochondrial dysfunction: implications for neurodegeneration. Free Radic Biol Med, 2003. 34(3): p. 287-303.
Kaneko, K., et al., Consequences of nitric oxide generation in epileptic-seizure rodent models as studied by in vivo EPR. Magn Reson Med, 2002. 48(6): p. 1051-6.
Liu, Z.W., T. Zhang, and Z. Yang, Involvement of nitric oxide in spatial memory deficits in status epilepticus rats. Neurochem Res, 2007. 32(11): p. 1875-83.
Engel, J., Jr., D.E. Kuhl, and M.E. Phelps, Patterns of human local cerebral glucose metabolism during epileptic seizures. Science, 1982. 218(4567): p. 64-6.
Engel, J., D.E. Kuhl, and M.E. Phelps, Regional brain metabolism during seizures in humans, in Advances in Neurology, A.V. Delgado-Escueta, et al., Editors. 1983, Raven Press: New-York. p. 141–148.
Engel, J., Jr., Metabolic patterns of human epilepsy: possible physiological correlates of clinical aberrations, in Current Problems in Epilepsy, M. Baldy-Moulinier and D.H.M.B.S. Ingvar, Editors. 1983, John Libbey Ltd: London. p. 6–18.
Meyer, J.S. and F. Gotoh, Cerebral metabolism during epileptic seizures in man. Trans Am Neurol Assoc, 1965. 90: p. 23-9.
Plum, F., J.B. Posner, and B. Troy, Cerebral metabolic and circulatory responses to induced convulsions in animals. Arch Neurol, 1968. 18(1): p. 1-13.
Posner, J.B., F. Plum, and A. Van Poznak, Cerebral metabolism during electrically induced seizures in man. Arch Neurol, 1969. 20(4): p. 388-95.
Mayevsky, A. Brain oxygen toxicity. Invited Review. in 8th Symp. Under-water Physiol. 1984. Bethesda, Maryland: Undersea Medical Society Inc.
O'Connor, M.J., et al., Intracellular redox changes preceding onset of epileptiform activity in intact cat hippocampus. J. Neurophysiol., 1972. 35: p. 471-483.
Van Buren, J.M., et al., Fluorometric monitoring of NADH levels in cerebral cortex: Preliminary observations in human epilepsy. Neurosurgery, 1978. 2(2): p. 114-121.
Nehlig, A., et al., Absence seizures induce a decrease in cerebral blood flow: human and animal data. J Cereb Blood Flow Metab, 1996. 16(1): p. 147-55.
Ronne-Engstrom, E., et al., Monitoring of cortical blood flow in human epileptic foci using laser Doppler flowmetry. J. Epilepsy, 1993. 6: p. 145–151.
Kreisman, N.R., J.C. Magee, and B.L. Brizzee, Relative hypoperfusion in rat cerebral cortex during recurrent seizures. J Cereb Blood Flow Metab, 1991. 11(1): p. 77-87.
Kreisman, N.R., T.J. Sick, and M. Rosenthal, Concepts of brain oxygen sufficiency during seizures. Adv Exp Med Biol, 1984. 180: p. 381-92.
Gilland, E., et al., Mitochondrial function and energy metabolism after hypoxia-ischemia in the immature rat brain: involvement of NMDA-receptors. J Cereb Blood Flow Metab, 1998. 18(3): p. 297-304.
Cleeter, M.W., et al., Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases. FEBS Lett, 1994. 345(1): p.
Granger, D.L. and A.L. Lehninger, Sites of inhibition of mitochondrial electron transport in macrophageinjured neoplastic cells. J Cell Biol, 1982. 95(2 Pt 1): p. 527-35.
Drapier, J.C. and J.B. Hibbs, Jr., Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible. J Clin Invest, 1986. 78(3): p. 790-7.
Przegalinski, E., L. Baran, and J. Siwanowicz, The role of nitric oxide in chemically- and electrically-induced seizures in mice. Neurosci Lett, 1996. 217(2-3): p. 145-8.
Chavko, M., et al., Role of cerebral blood flow in seizures from hyperbaric oxygen exposure. Brain Res, 1998. 791(1-2): p. 75-82.
Montecot, C., et al., Nitric oxide of neuronal origin is involved in cerebral blood flow increase during seizures induced by kainate. J Cereb Blood Flow Metab, 1997. 17(1): p. 94-9.
Sato, T., et al., Changes in nitric oxide production and cerebral blood flow before development of hyperbaric oxygen-induced seizures in rats. Brain Res, 2001. 918(1-2): p. 131-40.
Wang, Q., et al., Nitric oxide (NO) is an endogenous anticonvulsant but not a mediator of the increase in cerebral blood flow accompanying bicuculline-induced seizures in rats. Brain Res, 1994. 658(1-2): p. 192-8.
Theard, M.A., et al., The role of nitric oxide in modulating brain activity and blood flow during seizure. Neuroreport, 1995. 6(6): p. 921-4.
Mayevsky, A., Level of ischemia and brain functions in the Mongolian gerbil in vivo. Brain Res., 1990. 524: p. Mayevsky, A. (2024). Involvement of Nitric Oxide in Mitochondrial Activity and Brain Functions. British Journal of Healthcare and Medical Research,
Betz, E., H.G. Enzenross, and V. Viahov, Interactions of ionic mechanisms in the regulation of the resistance of pial vessels, in Cerebral Circulation and Metabolism, T.W. Langfitt, et al., Editors. 1975, Springer: New York.
Pickard, J.D., Ionic and eicosanoid regulation of Cercbrovascular Smooth Muscle Contraction, in Cerebral Blood Flow: Physiological and Clinical Aspects, J.H. Wood, Editor. 1987, McGraw Hill Book Company: New York.
Mayevsky, A., H. Kutai-Asis, and M. Tolmasov, Mitochondrial function and brain Metabolic Score (BMS) in ischemic Stroke: Evaluation of "neuroprotectants" safety and efficacy. Mitochondrion, 2020. 50: p. 170-194.
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