Respiratory Complex II and SCOT-Oxct1 Compete for succinyl-CoA in Ketolytic Dependent Tumours
DOI:
https://doi.org/10.14738/bjhmr.111.16217Keywords:
Tumour cell metabolism, SCOT- Oxct1, Ketolysis, Respiratory complexesAbstract
The present work recalls main features of tumour cell metabolism, explaining their ketolytic dependency and vulnerability; we explored the interface between the respiration chain complexes and the nutritional supply of succinyl-CoA to the ketolytic enzyme SCOT- Oxct1. We indicated several target points in ketolysis and fatty acid synthesis pathways that would affect tumour cells, rendered vulnerable by their ketolytic dependency.
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Copyright (c) 2024 Maurice Israël, Eric Berg, Guy Tenenbaum
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