Postmenopausal Hormone Replacement Therapy (HRT) May Cause Dementia: Are There Alternatives?
DOI:
https://doi.org/10.14738/bjhmr.111.16388Abstract
Based on recent observations and a study in which it was found that postmenopausal hormone replacement therapy (HRT) can cause an increased incidence of dementia, the question arises as to the causes of this and the purpose of this therapy. According to our experience, it can be assumed that these negative effects occur with chemical-artificial hormone replacement, since these are not identical with endogenous hormones. We contrast this with the existing possibilities of nature-identical treatments using the prohormone pregnenolone and agents of plant origin. So far we have not experienced any case of dementia with them.
References
Pourhadi N, Mørch LS, Holm EA, Torp-Pedersen Ch, Meaidi A; Menopausal hormone therapy and dementia: nationwide, nested case-control study, PMID: 37380194 PMCID: PMC10302215 DOI: 10.1136/bmj-2022-072770, https://pubmed.ncbi.nlm.nih.gov/37380194/
Kantarci K, Manson JE. Menopausal hormone therapy and dementia. BMJ. 2023 Jun 28 ;381 :1404. Doi : 10.1136/bmj. p1404. PMID : 37380188
Taudorf L, Nørgaard A, Islamoska S, Jørgensen K, Laursen TM, Waldemar G. Declining incidence of dementia : a national registry-based study over 20 years. Alzheimers Dement 2019 ;15 :1383-91. 10.1016/j.jalz.2019.07.006.
Peel E, Brooker D, Erol R. Women and dementia. Global research review. 2015. https://www.alzint.org/u/Women-and-Dementia.pdf
Snyder HM, Asthana S, Bain L, et al. Sex biology contributions to vulnerability to Alzheimer's disease : a think tank convened by the Women's Alzheimer's Research Initiative. Alzheimers Dement 2016 ;12 :1186-96. 10.1016/j.jalz.2016.08.004.
Strom JO, Theodorsson A, Theodorsson E. Mechanisms of estrogens' dose-dependent neuroprotective and neurodamaging effects in experimental models of cerebral ischemia. Int J Mol Sci 2011 ;12:1533-62. 10.3390/ijms12031533.
Villa A, Vegeto E, Poletti A, Maggi A. Estrogens, neuroinflammation, and neurodegeneration. Endocr Rev 2016 ;37 :372-402. 10.1210/er.2016-1007.
Rassow, Hauser, Netzker, Deutzmann: Biochemistry, 3rd edition, Thieme-Verlagsgruppe, ISBN 978-3-13-125353-8, p. 590f
M. Vallee, S. Vitiello et al : Pregnenolone Can Protect the Brain from Cannabis Intoxication. In: Science. 343, 2014, p. 94-98, doi:10.1126/science.1243985 197 British Journal of Healthcare and Medical Research (BJHMR)
www.mexican-wild-yam.de
Bühring Ursel: All about medicinal plants. Recognize, use and stay healthy. Ulmer, Stuttgart 2020, ISBN 978-3-8186-0410-3, p. 406
Foods of the Prophet [Internet]. [Cited 2011 Jun 12] ; Available from : http://www.chishti.org/foods_of_the_prophet.htm
Arabic Medicine : Unique Properties of Fenugreek [Internet]. Cited 2011 ; Available from : Archive link
Shumin Qiu, Chongmin Jiang : Soy and isoflavones consumption and breast cancer survival and recurrence : a systematic review and meta-analysis. In : European Journal of Nutrition. Vol. 58, No. 8, 2019, pp. 3079-3090, doi :10.1007/s00394-018-1853-4, PMID 30382332
Angela Mörixbauer: Soy, soy isoflavones and health effects, part 2. In: ernaehrungs-umschau.de. doi:10.4455/eu.2019.024
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Doepp, Manfred

This work is licensed under a Creative Commons Attribution 4.0 International License.