Ulcerous Colitis in Mexico: Is It Still a Diagnostic-Therapeutic Myth? 20 Years of Experience

Authors

  • Morelos Adolfo García Sánchez Surgical Department at “Dr. Rubén Leñero” General Hospital Secretary of Health of Mexico City, National Autonomous University of Mexico, México City
  • Carol Atzimba Zepeda Carrillo Surgical Department at “Dr. Rubén Leñero” General Hospital Secretary of Health of Mexico City, National Autonomous University of Mexico, México City, México
  • Julio Geovany Flores Hernández Surgical Department at “Dr. Rubén Leñero” General Hospital Secretary of Health of Mexico City, National Autonomous University of Mexico, México City, México
  • Gema Méndez Barrón Surgical Department at “Dr. Rubén Leñero” General Hospital Secretary of Health of Mexico City, National Autonomous University of Mexico, México City, México
  • Baruj Ricardo Lupio García Surgical Department at “Dr. Rubén Leñero” General Hospital Secretary of Health of Mexico City, National Autonomous University of Mexico, México City, México
  • Astrid Ortiz Vargas Surgical Department at “Dr. Rubén Leñero” General Hospital Secretary of Health of Mexico City, National Autonomous University of Mexico, México City, México
  • Alejandro Altamirano Jiménez Medicine Crítica Intensive Therapy Department. “La Villa” General Hospital Secretary of Health of Mexico City, National Autonomous University of Mexico, México City, México
  • Giselle Castillo García Surgical Department at “Dr. Rubén Leñero” General Hospital Secretary of Health of Mexico City National Autonomous University of Mexico, México City, México
  • Fabian Cazares Longines Surgical Department at “Dr. Rubén Leñero” General Hospital Secretary of Health of Mexico City, National Autonomous University of Mexico, México City, México
  • Jennifer Itzel Jacobo Godínez Surgical Department at “Dr. Rubén Leñero” General Hospital Secretary of Health of Mexico City National Autonomous University of Mexico, México City, México
  • Mara Luz Terán Estrella Surgical Department at “Dr. Rubén Leñero” General Hospital Secretary of Health of Mexico City National Autonomous University of Mexico, México City, México
  • María Isabel Estrada Rodríguez Podiatrist Pediatrician Department. Regional General Hospital No. 251, Metepec. Mexican Social Security Institute. National Autonomous University of Mexico. México State, México
  • Imelda Yasmín Palma Cortés Surgical Department at “Dr. Rubén Leñero” General Hospital Secretary of Health of Mexico City National Autonomous University of Mexico, México City, México
  • Mireya Fuente González Surgical Department at “Dr. Gaudencio González Garza” General Hospital Specialized Medical Unit, “La Raza”, National Medical Center, Mexican Social Security Institute, National Autonomous University of Mexico, México City, México
  • Sergio Fernández Zenteno Surgical Department at “Dr. Rubén Leñero” General Hospital Secretary of Health of Mexico City, National Autonomous University of Mexico, México City, México

DOI:

https://doi.org/10.14738/bjhmr.104.15189

Abstract

Nonspecific chronic ulcerative colitis is a variety of inflammatory bowel diseases which to date is of unknown etiology. The objective is to present the experience of 20 years in the diagnosis and treatment, in a multicenter study of nonspecific chronic ulcerative colitis in Mexico. With a study methodology with a retrospective, longitudinal, observational and descriptive design, in the Colon and Rectal Surgery and General Surgery services. Results: 181 patients with histopathologically confirmed diagnosis: 76 women (42%) and 105 men (58%). With an age range of 16 to 85 years, with a mean of 39 years, with a follow-up of 1 to 5 years from diagnosis, both clinically and colonoscopically; 63 cases (36) required surgery, 10 patients with colorectal cancer (2%): severe dysplasia and/or tumor (neoplasia), anal surgery reaches up to 25%. The statistical or epidemiological data of non-specific chronic ulcerative colitis to date are unknown or not very relevant to the public or private Health System in Mexico and/or in most of the world, with unreliable information, without scientific validation and only by the experience of some physicians with little unpublished casuistry.

References

Yamamoto-Furusho J.K., and Sánchez-Morales G.E. Changes in chronic idiopathic ulcerative colitis epidemiological pattern in Mexico in a tertiary care hospital. Gac Med Mex. 2021; 157(2):147-153.

Gassul M. A., y Mañosa M. Antecedentes históricos de la Colitis Ulcerosa. 2015; GETECCU grupo Español de Trabajo. 2015. Consultado en https://geteccu.org/pacientes/antecedentes-historicos/antecedenteshistoricos-de-la-colitis-ulcerosa.

Kirsner J. B. Historicalorigins of current IBD concepts. World J Gastroenterol 2001, 7(2): 175-184.

Mak J.W.Y., Sun Y., Limsrivilai J., et al. GIVES-21 Consortium. Development of the global inflammatory bowel disease visualization of epidemiology studies in the 21st century (GIVES-21). BMC Med Res Methodol. 2023; 23(1):129. doi: 10.1186/s12874-023-01944-2.

Khademi Z., Saneei P., Hassanzadeh-Keshteli A., et al. Association between food-based dietary inflammatory potential and ulcerative colitis: a case-control study. Sci Rep. 2023; 13(1):8464.

Törüner M., and Ünal N.G. Epigenetics of Inflammatory Bowel Diseases. Turk J Gastroenterol. 2023;

Woźniak M., Borkowska A., Jastrzębska M., et al. Clinical and Laboratory Characteristics of Anaemia in Hospitalized Patients with Inflammatory Bowel Disease. J Clin Med. 2023; 12(7):2447.

Martinelli V.F., Martinelli Barbosa P., Dantas de Oliveira L.S., et al. Atypical Forms of Pyoderma Gangrenosum in Inflammatory Bowel Disease: Report of Four Cases and Literature Review. Int Med Case Rep J. 2022; 15:449-456.

Bareche-Rivarés M., y Maza-Pérez M. Colitis ulcerosa: generalidades, signos y síntomas, complicaciones y tratamiento. Revista Electrónica de Portales Médicos. 2022; 7(2): 115.

Kahlam A. Khrais A. Khalessi A., and Ahlawat S. Trends and Complication Rates in Ulcerative Colitis Patients with and Without Helicobacter pylori Infections. Cureus. 2023; 15(4): e37345.

Sica G.S. Sensi B. Siragusa L., et al. Surgical management of colon cancer in ulcerative colitis patients with orthotopic liver transplant for primary sclerosing cholangitis. A systematic review. Eur J Surg Oncol. 2023; S0748-7983(23)00481-X.

Chavannes M., Hart L., Hayati Rezvan P., et al. Bedside Intestinal Ultrasound Predicts Disease Severity and the Disease Distribution of Pediatric Patients with Inflammatory Bowel Disease: A Pilot Cross-sectional Study. Inflamm Bowel Dis. 2023; izad083. doi: 10.1093/ibd/izad083.

Cabré E. Colitis ulcerosa. Diagnóstico y diagnóstico diferencial. GH Continuada. 2003; 2(6):241-245.

Baron J.H., Connell A.M., and Lennard-Jones J.E. Variation between observers in describing mucosal appearances in proctocolitis. Br Med J. 1964; 1(5375):89-92. doi: 10.1136/bmj.1.5375.89.

Lennard-Jones. J.E. Definition. and. diagnosis. In: Engel. A., and Larssen. T. Eds. Regional. enteritis. (Fifth. Skandia. International. Symposium.). 1968; 44:674.

Lennard-Jones J.E. Classification of inflammatory bowel disease. Scand J Gastroenterol Suppl. 1989; 170: 2-6.

Truelove S.C., and Witts L.J. Cortisone in ulcerative colitis; preliminary report on a therapeutic trial. Br Med J. 1954; 2(4884):375-8.

Truelove S.C., Witts L.J. Cortisone in ulcerative colitis; final report on a therapeutic trial. Br Med J. 1955;

Yamamoto-Furushoa J.K., Gutiérrez-Grobea Y., López-Gómez J. G., y cols. Consenso mexicano para el diagnóstico y tratamiento de la colitis ulcerosa crónica idiopática. Revista de Gastroenterología de México.2018; 83(2): 144-167.

Yamamoto-Furusho J.K., Bozada-Gutiérrez K.E., Sánchez-Rodríguez A., et al. Validación de un nuevo índice integral de enfermedad para evaluar el grado de actividad en pacientes mexicanos con colitis ulcerosa: un estudio de cohorte prospectivo. Revista de Gastroenterología de México.2019; 84(3): 317-325.

Mella-Sousa M., Zamora-Navas P., y Mella Laborde M. Niveles de Evidencia Clínica y Grados de Recomendación. Rev. S. And. Traum. y Ort., 2012; 29(1/2):59-72.

Wei S.C., Sollano J., Hui Y.T, et al. Epidemiology, burden of disease, and unmet needs in the treatment of ulcerative colitis in Asia. Expert Rev Gastroenterol Hepatol. 2021;15(3):275-289.

Kobayashi T., Hoshi M., Yuasa A., et al. Cost-Effectiveness Analysis of Tofacitinib Compared with Biologics in Biologic-Naïve Patients with Moderate-to-Severe Ulcerative Colitis in Japan. Pharmacoeconomics. 2023;

De León-Rendón J.L., Jiménez-Bobadilla B., López-Pérez R.Y., et al. Colitis ulcerosa crónica idiopática: epidemiología, características clínicas y factores asociados al tratamiento quirúrgico en un hospital de tercer nivel en México. Cirugía y Cirujanos. 2019; 87:250-458.

Ciriza-de-los-Ríos C., Mínguez M., Remes-Troche JM., and Lacima G. Manometría anorrectal de alta resolución y de alta definición: redescubriendo la función anorrectal. Revista Española de Enfermedades Digestivas. 2018; 110 (12), 794-805.

Ciriza de los Ríos C., Ruiz de León-San Juan A., Díaz-Rubio García M., y cols. Diferencias en las presiones del canal anal y la sensibilidad rectal en pacientes con incontinencia anal, estreñimiento crónico y sujetos sanos. Rev. esp. enferm. dig. 2010; 102(12): 683-690.

Mishra R, Gautam M, Oblizajek NR, Bharucha AE. Reproducibility of high-resolution manometry among healthy and constipated persons. Neurogastroenterol Motil. 2022; 34(12): e14438

Oliveira L., Galindo G.F.H.R., Silva-Velazco J.D. Benign Anorectal Disorder Management in Low-Resource Settings. Clin Colon Rectal Surg. 2022; 35(5):376-389.

Obi M., and Steele S.R. Anorectal Anatomy Quiz: Test Your Knowledge. J Gastrointest Surg. 2023., doi: 10.1007/s11605-023-05646-4.

Košťálová K., Suchánek Š., Zavoral M. Update and review of diagnosing functional anorectal disorders -standardized protocol for high-resolution anorectal manometry and the London classification. Rozhl Chir. 2020; 99(6):249-257.

Wang X., Shen B. Advances in Perianal Disease Associated with Crohn's Disease-Evolving Approaches. Gastrointest Endosc Clin N Am. 2019l;29(3):515-530.

DeLeon M.F., Stocchi L. Elective and Emergent Surgery in the Ulcerative Colitis Patient. Clin Colon Rectal Surg. 2022; 35(6):437-444.

Turner D., Ricciuto A., Lewis A., et al. International Organization for the Study of IBD. STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): Determining Therapeutic Goals for Treat-to-Target strategies in IBD. Gastroenterology. 2021; 160(5):1570-1583.

Allocca M., Furfaro F., Fiorino G., et al. Point-of-Care Ultrasound in Inflammatory Bowel Disease. J Crohns Colitis. 2021; 15(1):143-151.

Chatterji M., Fidler J.L., Taylor S.A., et al. State of the Art MR Enterography Technique. Top Magn Reson Imaging. 2021; 30(1):3-11.

Urquizo-Ayala G., Arteaga-Coarite R., y Chacón Yucra P. Utilidad de los reactantes de fase aguda en el diagnóstico clínico. Rev. Méd. 2019; 25 (2): 91-98.

Fernando-Fernández-B., Accarinob,i A, Balboac A., et al. Diarrea crónica: definición, clasificación y diagnóstico. Gastroenterología y Hepatología. 2016; 39(8):535-559.

Lepe-Balsalobre E., y Rubio-Sánchez R. et al. Frecuencia de parasitismo intestinal en niños con diarrea persistente en el Área Sanitaria Sur de Sevilla. Revista Cubana de Medicina Tropical. 2021; 73(3): e706.

Murray J., Kok K.B., Ayling R.M. Fecal Calprotectin in Gastrointestinal Disease. Clin Chem. 2023: hvad051.

Ramos-García Jonathan, Blanco-Velasco Gerardo. Eficacia y seguridad de la cápsula de permeabilidad en comparación con enterografía por resonancia magnética para predecir la retención de cápsula endoscópica en pacientes con enfermedad de Crohn. Endoscopia [revista en la Internet]. 2020; 32(Suppl 2): 649-652.

Kandel R., Merlano M., Tan P., et al. Persistently High Rates of Abdominal Computed Tomography Imaging Among Patients with Inflammatory Bowel Disease Who Present to the Emergency Department. J Can Assoc Gastroenterol. 2022; 6(2):64-72.

Morelos Adolfo García Sánchez., et al. “Colonoscopy in Mexico, 18 Years of Experience”. EC Gastroenterology and Digestive System 2021; 8.2 (): 68-77.

Cerna-Cardona J., Peláez-Luna M. C., Casillas-Guzmán G. B., et al. Guía de endoscopia en enfermedad inflamatoria intestinal. Endoscopia. 2021; 33 (1): 22-44.

Rath T., Atreya R., Bodenschatz J., et al. Intestinal Barrier Healing Is Superior to Endoscopic and Histologic Remission for Predicting Major Adverse Outcomes in Inflammatory Bowel Disease: The Prospective ERIca Trial. Gastroenterology. 2023; 164(2):241-255.

Mayo Clínic. Colitis Ulcerosa. 2023. Consultado 13 de junio del 2023. https://www.mayoclinic.org/eses/diseases-conditions/ulcerative-colitis/diagnosis-treatment/drc-20353331#:~:text=Los%20procedimientos%20endosc%C3%B3picos%20con%20biopsia,como%20la%20enfermedad%20de%20Crohn.

Atanassova A., Georgieva A. Circulating miRNA-16 in inflammatory bowel disease and some clinical correlations - a cohort study in Bulgarian patients. Eur Rev Med Pharmacol Sci. 2022; 26(17):6310-6315.

De Frias Gomes C.G., De Almeida A.S.R., Mendes C.C.L., et al. Histological Inflammation in the Endoscopically Uninflamed Mucosa is Associated with Worse Outcomes in Limited Ulcerative Colitis. Inflamm Bowel Dis. 2022; 28(3):350-357.

Morales-Polanco S., y Waller-González L.A. Validación del Índice de Severidad Endoscópico de Colitis Ulcerativa para la población mexicana. 2016; 28:2-8.

Song Z., Zhang M., Ren Y., Iang B. [Improved Mayo Endoscopic Score has a higher value for evaluating clinical severity of ulcerative colitis]. Nan Fang Yi Ke Da Xue Xue Bao. 2022; 42(7):997-1005.

Ruan GC, Jin X, Zhou WX, You Y, Iacucci M, Ghosh S, Gui XY, Li J, Qian JM. External validation of the Paddington International Virtual Electronic ChromoendoScopy ScOre as a good endoscopic score to define mucosal healing and predict long-term clinical outcomes in ulcerative colitis. J Dig Dis. 2022; 23(8-9):446-454.

Sakai M., Hayashi K., Ito T., et al. Sustained effect of leukocytapheresis/granulocytapheresis versus antihuman TNF-α monoclonal antibody on ulcerative colitis: A 2-year retrospective study. Medicine (Baltimore). 2023; 102(16): e33368.

Mohammed V.N., Samaan M., Mosli M.H., Endoscopic scoring indices for evaluation of disease activity in ulcerative colitis. Cochrane Database Syst Rev. 2018; 1(1):CD011450.

Paredes-Méndez J.E., Alosilla-Sandoval P.A., Quiroga-Purizaca W.G., et al. Evaluación de actividad endoscópica e histológica como predictores de recaída clínica en colitis ulcerativa. Rev. gastroenterol. 2019; 39(3): 222-228.

Gupta R.B., Harpaz N., Itzkowitz S., et al. Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: a cohort study. Gastroenterology. 2007; 133(4):1099-105.

Delaney C.P., Remzi F.H., Gramlich T., et al. Equivalent function, quality of life and pouch survival rates after ileal pouch-anal anastomosis for indeterminate and ulcerative colitis. Ann Surg. 2002; 236(1):43-8.

Dignassa, A., Lindsaya, J.O., Sturma A. et al. Segundo consenso europeo basado en evidencia sobre el diagnóstico y manejo de la colitis ulcerosa crónica idiopática. Parte 2: tratamiento actual. Rev. Gastroenterología de México. 2015; (80) 1: 32-73.

Ginard D., Marín-Jiménez I., Barreiro-de-Acosta M., et al. Recomendaciones del Grupo Español de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa (GETECCU) sobre el tratamiento tópico en la colitis ulcerosa, Gastroenterología y Hepatología.2020; (43) : 97-105.

Wei M., Liu D., Sun Y.,et al. Mesalazine hollow suppositories based on 3D printing for treatment of ulcerative colitis. Int J Pharm. 2023; 642:123196.

López-Roldán G., Alba-López C., y Taxonera C. Diagnóstico y tratamiento de la enfermedad inflamatoria intestinal. 2022; 139(1): 31-35.

Yamamoto-Furusho J.K., Bosques-Padilla F.J., Martínez-Vázquez M.A., y cols. Segundo Consenso Mexicano de terapia biológica y moléculas pequeñas en enfermedad inflamatoria intestinal. Revista Gastroenterológica de México. 2021; 86: 70-85.

Kosaraju R.S.., Wong DJ., Roth E.M., et al. Dose-Intensified Infliximab Rescue Therapy for Severe Ulcerative Colitis Does Not Reduce Short-term Colectomy Rates or Increase Postoperative Complications. Dis Colon Rectum. 2022; 65(10):1232-1240. 161

Tursi A., Mocci G., Cingolani L., et al. Use of tofacitinib as first or second-line therapy is associated with better outcomes in patients with ulcerative colitis: data from a real-world study. Expert Opin Pharmacother. 2023:1-8. doi: 10.1080/14656566.2023.2230126.

Adimadhyam S., Lewis J.D., Simon A.L., et al. Real-world Evidence Comparing Tofacitinib and Vedolizumab in Anti-TNF-experienced Patients with Ulcerative Colitis. Inflamm Bowel Dis. 2023: izad115. doi: 10.1093/ibd/izad115.

Lindemann A., Roth D., Koop K., Protective effect of the novel calcineurin inhibitor voclosporin in experimental colitis. Front Med (Lausanne). 2023; 10:1177450.

Marsool M.D.M., Vora N., Marsool A.D.M., et al. Ulcerative colitis: Addressing the manifestations, the role of fecal microbiota transplantation as a novel treatment option and other therapeutic updates. Dis Mon. 2023:101606.

Lopetuso L.R., Deleu S., Godny L., et al. The first international Rome consensus conference on gut microbiota and faecal microbiota transplantation in inflammatory bowel disease. Gut. 2023: gutjnl-2023-329948. doi: 10.1136/gutjnl-2023-329948.

Sambuelli M.A., Negreira S., Guil A., et al. Manejo de la enfermedad inflamatoria intestinal. Revisión y algoritmos de manejo. Acta Gastroenterol Latinoam 2019; 49(S2).

Keam S.J., Mirikizumab: First Approval. Drugs. 2023; 83(11):1045-1052. doi: 10.1007/s40265-023-01909-1. PMID: 37389706.

Aktaş M.K., Gülmez M., Sahar A.A., et al. Current Status and Surgical Technique for Restorative Proctocolectomy with Ileal Pouch Anal Anastomosis. Balkan Med J. 2023. doi: 10.4274/balkanmedj.

Derks M.E., Te Groen M., Peters C.P., et al. Dutch Initiative on Crohn and Colitis. Endoscopic and surgical treatment outcomes of colitis-associated advanced colorectal neoplasia: a multicenter cohort study. Int J Surg. 2023. doi: 10.1097/JS9.0000000000000335.

Hirai M., Yanai S., Kunisaki R., et al. The effectiveness of endoscopic resection for colorectal neoplasms in ulcerative colitis: a multicenter registration study. Gastrointest Endosc. 2023 May 30: S0016-5107(23)02606-8. doi: 10.1016/j.gie.2023.05.058.

Subhaharan D., Ramaswamy P.K., Willmann L., et al. older adults with acute severe ulcerative colitis have similar steroid non-response and colectomy rates as younger adults. World J Gastroenterol. 2023;

Festa S., Scribano M.L., Pugliese D., et al. Long-term outcomes of acute severe ulcerative colitis in the rescue therapy era: A multicentre cohort study. United European Gastroenterol J. 2021; 9(4):507-516.

Lundberg B. A., Olén O., Söderling J., et al. Colectomy in patients with ulcerative colitis is not associated to future diagnosis of primary sclerosing cholangitis. United European Gastroenterol J. 2023; 11(5):471-481.

Le Cosquer G., Capirchio L., Rivière P., et al. Time trend in surgical indications and outcomes in Ulcerative Colitis-A two decades in-depth retrospective analysis. Dig Liver Dis: S1590-8658(23)00516-9. doi: 10.1016/j.dld.2023.03.003.

Fleshner P.R. Manejo quirúrgico de la colitis ulcerosa. Uptodate. 2023; https://www.uptodate.com/contents/surgical-management-of-ulcerative-colitis.

Jochum S.B., Bhama A.R. Radiographic guidance for Turnbull-Weakley blowhole colostomy. Tech Coloproctol.

Ooi B.S., Remzi F.H., Fazio V.W. Turnbull-Blowhole colostomy for toxic ulcerative colitis in pregnancy: report of two cases. Dis Colon Rectum. 2003; 46(1):111-5.

Zheng L., Wu L., Zhang B., et al. Sigmoid colon perforation with splenic abscess due to ulcerative colitis: A case report and review of the literature. Int J Surg Case Rep. 2023; 104:107938.

Goldstone R.N., Steinhagen R.M. Abdominal Emergencies in Inflammatory Bowel Disease. Surg Clin North Am. 2019; 99(6):1141-1150.

McDowell C., Farooq U., Haseeb M. Inflammatory Bowel Disease. 2023. In: StatPearls. Treasure Island (FL): StatPearls

Carpenter E.L., Valdera F.A., Chauviere M.V., Krell R.W. Outcomes of Partial Versus Total Colectomy in Ulcerative Colitis: A Propensity Score-Matched Analysis. J Surg Res. 2023; 287:63-71.

Hassan Y., Connell W.R., Rawal A., Wright E.K. Review of long-term complications and functional outcomes of ileoanal pouch procedures in patients with inflammatory bowel disease. ANZ J Surg. 2023; 93(6):1503-1509.

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Published

2023-07-31

How to Cite

Sánchez, M. A. G., Carrillo, C. A. Z., Hernández, J. G. F., Barrón, G. M., García, B. R. L., Vargas, A. O., … Zenteno, S. F. (2023). Ulcerous Colitis in Mexico: Is It Still a Diagnostic-Therapeutic Myth? 20 Years of Experience. British Journal of Healthcare and Medical Research, 10(4), 145–163. https://doi.org/10.14738/bjhmr.104.15189

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