Paediatric Pontine Glioma in Southeast Nigeria: A Case Report
DOI:
https://doi.org/10.14738/bjhmr.102.14400Keywords:
Paediatric, pontine glioma, Southeast, Nigeria, poor prognosisAbstract
A pontine glioma is a diffuse intrinsic brainstem tumour1,2. Histologically it has a high degree of tumour anaplasia with necrosis (high grade III-IV). The prognosis for intrinsic brainstem glioma is extremely poor as the tumour is inoperable, radiotherapy and chemotherapy are not curative and median survival is less than one year.
References
National cancer institute: PDQ – childhood brainstem glioma treatment; Bethesda MD http://www.cancer .gov/types/brain/patient/child-glioma-treatment pdq.
Clinical management and evolving novel therapeutic strategies for patients with brain tumour s: Brainstem gliomas by Zhiping Zhou and Mark Souweidane; chapter 18 DOI: 10.5772/53887
Epstein FJ and JP Farmer, Brainstemglioma growth patterns. J Neurosurg 1993 78(3): p408-12
Zarghooni M et al; Whole genome profiling of paediatric diffused intrinsic pontine gliomas highlights platelet derived receptor alpha and poly (ADP-ribose) polymerase as potential therapeutic targets. J. Clin. Oncol. 2010 28(8):p133-44.
Puget S et al Mesenchymal transition and amplification/mutation are key distinct oncogenic events in paediatric DIPG. Plos one 2012 7(2) p e303-13
Gilbertson RJ et al. ERBB1 is amplified and over expressed in high grade diffused infiltrative brainstem glioma. Clin. Cancer Res, 2003.9(10pt1); p 3620-4
Badhe PB, Chauhan PP and Menta NK. Brainstem gliomas- a clinicopathological study of 45cases with p53 immunochemistry. Indian J cancer 2004 41(4) p 170-4
Zhang S et al; p53 gene mutations in pontine gliomas of juvenile onset. Biochem Biophys Res Commun, 1993 196(2); p851-7
Central Brain Tumour Registry of the United States CBTRUS Statistical Report. Primary brain and central nervous system tumours diagnosed in the Unite states in 2004-2008. 2012
Ndubuisi CA, Ohaegbulam SC, Ejembi GO. Paediatric brain tumours managed in Enugu, Southeast Nigeria: Review of one centre experience. Niger Postgrad Med J [serial online] 2018 [cited 2022 Dec 30]; 25:186-90.
Ogun GO, Adeleye AO, Babatunde TO, Ogun OA, Salami A, Brown BJ, et al. Central nervous system tumours in children in Ibadan, Nigeria: A histopathologic study. Pan Afr Med J 2016; 24:34.
Uche EO, Shokunbi MT, Malomo AO, Akang EE, Lagunju I, Amanor-Boadu SD. Pediatric brain tumors in Nigeria: Clinical profile, management strategies, and outcome. Childs Nerv Syst 2013; 29:1131-5.
Aghadiuno PU, Adeloye A, Olumide AA, Nottidge VA. Intracranial neoplasms in children in Ibadan, Nigeria. Childs Nerv Syst 1985; 1:39-44.
Kaplan AM et al, Brainstem gliomas in children. A children’s Cancer group review of 119cases. Paeditr Neurosurg, 1996. 24(4) p 185-92
Porto et al; Proton magnetic resonance spectroscopy in childhood brain lesions. Childs Nerv Syst, 2007 23(3) p 305-14
Albright, A. Leland M.D.; Packer, Roger J. M.D.; Zimmerman, Robert M.D.; Rorke, Lucy B. M.D.; Boyett, James Ph.D.; Hammond, G. Denman M.D. Magnetic Resonance Scans Should Replace Biopsies for the Diagnosis of Diffuse Brain Stem Gliomas: A Report from the Children's Cancer Group. Neurosurgery 33(6):p 1026-1030, December 1993.
Stroink AR, Hoffman HJ, Hendrick EB, Humphreys RP. Diagnosis and management of pediatric brainstem gliomas. J Neurosurg 65: 745- 750, 1986
Thakur SB et al. Longitudinal MR spectroscopic imaging of paediatric diffuse pontine tumours to assess tumour aggression and progression. AJNR (Am J Neuroradiol) 2006 27(4) p806-9
Treatment of newly diagnosed brainstem gliomas in children. David Korones http://www.expert –reviews .com /doi/abs/10.1586/14737140.7.5.663
Recurrence /Relapses/ DIPG Registry
Ajugwo AO. Negative effects of gas flaring: The Nigerian experience. J Environ Pollut Hum Health 2013; 1:6-8.
Ndubuisi CA, Ohaegbulam SC, Chikani MO, Mezue WC, Mbadugha T, Okhueleigbe M. Some characteristics of gliomas managed at a Neurosurgery centre in Nigeria. Niger Postgrad Med J 2017; 24:44-7
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Eneh, C. I., Egwuonwu A. C.

This work is licensed under a Creative Commons Attribution 4.0 International License.