Alcohol Induced Acute Kidney Injury in A 13-Year-Old Nigerian Boy; A Case Report
DOI:
https://doi.org/10.14738/bjhmr.102.14467Keywords:
alcohol, acute kidney injury, teenager, haemodialysisAbstract
Alcohol misuse has been insinuated to be a cause of acute kidney injury with various patho-mechanisms suggested. We present a case of a 13 year old Nigerian boy who was admitted on account of vomiting of 4 episodes of 24 hours duration, convulsion of several episodes within 3hrs prior to presentation and associated loss of consciousness. He was apparently well until the outset of symptoms which were preceded by ingestion of about 250mls of ‘LORDS’ dry gin containing 43% alcohol mixed with Cocacola.The urinary output was 0.67mls/kg/hr on the first day of admission while the peak serum creatinine value was 1425.2µmol/l. The random blood sugar at admission was 14mmol/l. He was given intravenous fluid 5% Dextrose /saline, intravenous phenytoin, diazepam 5mg, and antibiotic. He had 2 sessions of haemodialysis within 48 hours apart. Subsequently, he regained full consciousness after the first session of dialysis and the creatinine level at discharge was 73µmol/l with urine output of 1.67ml/min/hr. He was co-managed with the Psychiatrist and the duration of admission was 16 days. He is being followed up after discharge at the Paediatric nephrology clinic.
References
Center for Behavioral Health Statistics and Quality. Key Substance Use and Mental Health Indicators in the United States: Results from the 2015 National Survey on Drug Use and Health. Rockville, MD: Substance Abuse and Mental Health Services Administration; 2016. [Accessed December 28, 2016]. ((HHS Publication No. SMA 16-4984, NSDUH Series H-51)). https://www.samhsa.gov/data/sites/default/files/NSDUH-FFR1-2015/NSDUH-FFR1-2015/NSDUH-FFR1-2015.
Varga Z V, Matyas C, Paloczi J. Alcohol Misuse and kidney Injury: Epidemiological Evidence and Potential Mechanisms. Alcohol Res.2017;38(2):283-288
Adeoye et al . Epidermiology of harmful use of alcohol in Nigeria : a systemic review and meta-analysis. The American Journal of Drug and Alcohol Abuse, 45(5). pp . 438-450 ISSN 0095- 2990.
Agofure O, Okandeji-Barry O,Odjimogho S. Prevalence of Alcohol consumption among primary and secondary adolescents in Obiaruku Community in Delta State, Southern Nigeria.(2020). Afr. J. Biomed. Res . 23:35-40
Obot, I.S., Ibanga, A.J., Ojiji, O.O., and Wai, P. (2001). Drug and alcohol consumption by out of school Nigerian adolescents. African Journal of Drug and Alcohol Studies 98-109.
Alex-Hart, B.A., Opara, P.I., and Okagua, J. (2015). Prevalence of alcohol consumption among secondary school students in Port Harcourt, Southern Nigeria. Nigerian Journal of Paediatrics 42 (1): 39 – 45.
Obot IS. The measurement of drinking patterns and alcohol problems in Nigeria. Journal of substance abuse. 2000;12(1-2):169-81.
Emeka Dumbili .Changing patterns of alcohol consumption in Nigeria. An exploration of responsible factors and consequences. (2013).Journal of BSA MedSoc Group.7:1
Eze, N.M., Njoku, H.A., Eseadi, C., Akubue, B.N., Ezeanwu, A.B., Ugwu, U.C., and Ofuebe, J.I.(2017). Alcohol consumption and awareness of its effects on health among secondary school students in Nigeria. Medicine 96:48.
Fatoye, F.O., and Morakinyo, O. (2002). Substance use amongst secondary school students in rural and urban communities in south western Nigeria. East African Medical Journal 79(6):299–305.
Shu-Ting Chang, Yu-Ting Wang, Yi-Chou Hou, I-Kuan Wang, Hsiang-Hsi Hong, Wen-Hung Huang, Ching-Wei Hsu, Tzung-Hai Yen. Acute kidney injury and the risk of mortality in patients with methanol intoxication. BMC Journal of Nephrology. (2019) 20:205 https://doi.org/10.1186/s12882-019-1404-0
Andreucci M, Faga T, Pisani A, Perticone M, Michael A. The ischemic/ nephrotoxic acute kidney injury and the use of renal biomarkers in clinical practice. Eur J Intern Med. 2017;39:1–8. 5.
Weng CH, Chen HH, Hu CC, Huang WH, Hsu CW, Fu JF, Lin WR, Wang IK, Yen TH. Predictors of acute kidney injury after paraquat intoxication. Oncotarget. 2017;8(31):51345–54.
Cheungpasitporn W, Thongprayon C, Kittanamongkolchai W. High alcohol consumption and risk of renal damage: A systematic review and meta-analysis. QJM:Monthly Journal of the Association of Physicians.2015;108:539-548.
Cederbaum AI, Lu Y,Wu D. Role of oxidative stress in alcohol-induced liver injury. Archives of Toxicology. 2009;83: 519-548.
Kono H, R usyn I, Yin M. NADPH oxidase derived liver enzyme. Journal of Clinical Investigation. 2000;106(7):867-872.
Substance Abuse and Mental Health Services Administration (SAMHSA), Center for Behavioral Health Statistics and Quality. 2019 National Survey on Drug Use and Health. Alcohol Use Disorder in Past Year Among Persons Aged 12 or Older, by Age Group and Demographic Characteristics: Numbers in Thousands, 2018 and 2019. https://www.samhsa.gov/data/sites/default/files/reports/rpt29394/NSDUHDetailedTabs2019/NSDUHDetTabsSect5pe2019.htm?s=5.4tab5-4a.
Dumbili E. Changing Patterns of Alcohol Consumption in Nigeria: An Exploration of Responsible factors and Consequences. A Journal of the BSA MedSoc Group. 2013;7(1):28-33.
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