Metabolic Syndrome in Children with Overweight and Obesity
DOI:
https://doi.org/10.14738/jbemi.94.12740Abstract
Background: While many studies have been conducted on the prevalence and complications of metabolic syndrome in adults, few pediatric studies are available, particularly in developing countries. The aim of this study is to determine the prevalence of metabolic syndrome and its components among children and adolescents with overweight and obesity in Sfax, Tunisia. as well as to look for predictive factors for the occurrence of this pathology. Methods: This cross-sectional study involved 84 children and adolescents with overweight and obesity admitted to the endocrinology department of Hédi Chaker Hospital, Sfax from 2015 to 2019. For each participant included in the study, a clinical examination was conducted to determine height (cm), weight (kg), waist circumference (cm), and BMI as weight/height² (kg/m2). A fasting blood sample was taken to assay the different biological parameters. Results: Between 44 boys and 40 girls, the average age was 11.83 years. Family history of obesity was noted in 84.5% of cases. The average weight was 72.68 kg, with an average BMI of 31.55 kg/m². Obesity was reported in 78.6% of patients and overweight without obesity in 21.4%. According to adapted NCEP/ATP III criteria, 16.7% of patients had metabolic syndrome. Metabolic syndrome was observed in 15.9% of boys and 17.5% of girls, with no significant difference. In our study, no predictive factors were found. Conclusion: The prevalence of metabolic syndrome was high in our study. We suggest targeted screening programs for at-risk children and adolescents to control obesity and metabolic syndrome in Tunisia.
References
Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes. 1988 Dec;37(12):1595-607.
National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 2002 Dec 17;106(25):3143-421.
Burgert TS, Taksali SE, Dziura J, Goodman TR, Yeckel CW, Papademetris X, et al. Alanine aminotransferase levels and fatty liver in childhood obesity: associations with insulin resistance, adiponectin, and visceral fat. J Clin Endocrinol Metab. 2006 Nov;91(11):4287-94.
Muntner P, Srinivasan S, Menke A, Patel DA, Chen W, Berenson G. Impact of childhood metabolic syndrome components on the risk of elevated uric acid in adulthood: the Bogalusa Heart Study. Am J Med Sci. 2008 May;335(5):332-7.
Miller JM, Kaylor MB, Johannsson M, Bay C, Churilla JR. Prevalence of metabolic syndrome and individual criterion in US adolescents: 2001-2010 National Health and Nutrition Examination Survey. Metab Syndr Relat Disord. 2014 Dec;12(10):527-32.
Jmal L, Jmal A, Abdennebi M, Feki M, Boukthir S. Prevalence of metabolic syndrome in Tunisian overweight and obese children. Tunis Med. 2019 Jan;97(1):133-9.
World Health Organization WH. Definition, diagnosis and classification of diabetes mellitus and its complications: report of a WHO consultation. Part 1, Diagnosis and classification of diabetes mellitus. 1999 [cited 2021 Apr 18]; Available from: https://apps.who.int/iris/handle/10665/66040
Alberti KGMM, Zimmet P, Shaw J, IDF Epidemiology Task Force Consensus Group: The metabolic syndrome: a new worldwide definition. Lancet 2005 Sep 24;366(9491):1059-62.
Alberti KGMM, Zimmet P, Shaw J. Metabolic syndrome—a new world-wide definition. A consensus statement from the international diabetes federation. Diabet Med J Br Diabet Assoc. 2006 May;23(5):469-80.
Bloomgarden ZT. American Association of Clinical Endocrinologists (AACE) consensus conference on the insulin resistance syndrome: 25-26 August 2002, Washington, DC. Diabetes Care. 2003 Apr;26(4):1297-303.
Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ. 2000 May 6;320(7244):1240-3.
Cook S, Weitzman M, Auinger P, Nguyen M, Dietz WH. Prevalence of a metabolic syndrome phenotype in adolescents: findings from the third National Health and Nutrition Examination Survey, 1988-1994. Arch Pediatr Adolesc Med. 2003 Aug 1;157(8):821-7.
Zhu S, Wang Z, Heshka S, Heo M, Faith MS, Heymsfield SB. Waist circumference and obesity-associated risk factors among whites in the third National Health and Nutrition Examination Survey: clinical action thresholds. Am J Clin Nutr. 2002 Oct;76(4):743-9.
Glueck CJ, Woo JG, Khoury PR, Morrison JA, Daniels SR, Wang P. Adolescent oligomenorrhea (age 14-19) tracks into the third decade of life (age 20-28) and predicts increased cardiovascular risk factors and metabolic syndrome. Metabolism. 2015 Apr;64(4):539-53.
Zimmet P, Alberti KGMM, Kaufman F, Tajima N, Silink M, Arslanian S, et al. The metabolic syndrome in children and adolescents—an IDF consensus report. Pediatr Diabetes. 2007 Oct;8(5):299-306.
Bitew ZW, Alemu A, Ayele EG, Tenaw Z, Alebel A, Worku T. Metabolic syndrome among children and adolescents in low and middle income countries: a systematic review and meta-analysis. Diabetol Metab Syndr. 2020;12(1):1-23.
Jamoussi H, Mahjoub F, Sallemi H, Berriche O, Ounaissa K, Amrouche C, et al. Metabolic syndrome in Tunisian obese children and adolescents. Tunis Med. 2012 Jan;90(1):36-40.
Regaieg S, Nadia C, Kamoun S, Mouna E, Rim M, Jamoussi K, et al. Prevalence of metabolic syndrome and its components among overweight and obese secondary school adolescent in Sfax, Tunisia. Int J Clin Nutr. 2015 Mar 30;3:1-6.
Ahmadi N, Sadr SM, Mohammadi MR, Mirzaei M, Mehrparvar AH, Yassini Ardekani SM, et al. Prevalence of abdominal obesity and metabolic syndrome in children and adolescents: a community based cross-sectional study. Iran J Public Health. 2020 Feb;49(2):360-8.
Mahajan N, Kshatriya GK. Prevalence of metabolic syndrome and associated risk factors among tribal adolescents of Gujarat. Diabetes Metab Syndr. 2020 Oct;14(5):995-9.
Wang J, Zhu Y, Cai L, Jing J, Chen Y, Mai J, et al. Metabolic syndrome and its associated early-life factors in children and adolescents: a cross-sectional study in Guangzhou, China. Public Health Nutr. 2016 May;19(7):1147-54.
DeBoer MD. Assessing and managing the metabolic syndrome in children and adolescents. Nutrients. 2019 Aug 2;11(8):1788.
Qin X, Qiu L, Tang G, Tsoi M-F, Xu T, Zhang L, et al. Prevalence of metabolic syndrome among ethnic groups in China. BMC Public Health. 2020 Mar 6;20(1):297.
Romero-Velarde E, Aguirre-Salas LM, Álvarez-Román YA, Vásquez-Garibay EM, Casillas-Toral E, Fonseca-Reyes S. Prevalence of metabolic syndrome and associated factors in children and adolescents with obesity. Rev Medica Inst Mex Seguro Soc. 2016 Sep;54(5):568-75.
Abdennebi M, Ben Cheikh S, Bouaziz A, Ochi H, Ayadi I, Khammassi I, et al. Prévalence du syndrome métabolique chez des enfants obèses tunisiens âgés de 6 à 12 ans. Obésité [Internet]. 2011 Dec 1 [cited 2021 Apr 19];6(4):235-41. Available from: https://doi.org/10.1007/s11690-011-0299-4
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Copyright (c) 2022 Sidina Mohamed Elmoctar, Dhoha Ben Salah; Mouna Elleuch; Mohamed Abdellahi Mohamed Ahmed, Boujelban Khouloud, Mouna Mnif, Fatma Mnif, Nabila ReKik, Charfi Nadia, Hadj Kacem Faten, Mohamed Abid

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