Establishment of a Surgery-Induced Osteoarthritis Rat Model
DOI:
https://doi.org/10.14738/jbemi.91.11572Keywords:
Anterior cruciate ligament transection, degenerative arthritis, medial meniscectomy, osteoarthritis, rat model, surgeryAbstract
The degenerative arthritis has been a common knee joint disease in Taiwan. In mild cases of degenerative arthritis, it may just be a little uncomfortable to walk, but severe degenerative arthritis will cause difficulty in walking and even loss of basic mobility. The loss of articular cartilage in degenerative arthritis is irrecoverable. Currently, the degeneration of the knee joint can be easily divided into three levels based on its severity: primary, intermediate, and severe. The choice of treatments for degenerative arthritis will vary in according to different levels that is mainly divided into the non-surgical treatment and surgical treatment. Therefore, how to prevent knee joint degeneration is an important issue. In this study, anterior cruciate ligament transection (ACLT) plus medial meniscectomy (MMx) surgery were used to established a rat model with degenerative arthritis. According to all data, we have successfully established a rat model with degenerative arthritis via ACLT-MMx surgery. We wish this model will applied on the research of degenerative arthritis drugs and the design of therapeutic strategies for degenerative arthritis in the future.
References
Litwic A, Edwards MH, Dennison EM, Cooper C. Epidemiology and burden of osteoarthritis. Br. Med. Bull. 2013;105: 185-199.
Dominick KL, Ahern FM, Gold CH, Heller DA. Health-related quality of life and health service use among older adults with osteoarthritis. Arthritis Rheum. 2004;51: 326-331.
Hunter DJ, Riordan EA. The impact of arthritis on pain and quality of life: an Australian survey. Int. J. Rheum. Dis. 2014;17: 149-155.
Roos EM, Arden NK. Strategies for the prevention of knee osteoarthritis. Nat. Rev. Rheumatol. 2016;12: 92-101.
O’Neill TW, Felson DT. Mechanisms of osteoarthritis (Oa) pain. Curr. Osteoporos. Rep. 2018;16: 611-616.
Wehling P, Evans C, Wehling J, Maixner W. Effectiveness of intra-articular therapies in osteoarthritis: a literature review. Ther. Adv. Musculoskelet Dis. 2017;9: 183-196.
Busse P, Vater C, Stiehler M, Nowotny J, Kasten P, Bretschneider H, Goodman SB, Gelinsky M, Zwingenberger S. Cytotoxicity of drugs injected into joints in orthopaedics. Bone Joint Res. 2019;8: 41-48.
Kao JH, Lin SH, Lai CF, Lin YC, Kong ZL, Wong CS. Shea Nut oil triterpene concentrate attenuates knee osteoarthritis development in rats: evidence from knee joint histology. PLoS ONE. 2016;11: e0162022.
Chen IJ, Lin SH, Wong CS. Oral Shea nut oil triterpene concentrate supplement ameliorates pain and histological assessment of articular cartilage deterioration in an aclt injured rat knee osteoarthritis model. PLoS ONE. 2019;14: e0215812.
Da Silva KA, Paszcuk AF, Passos GF, Silva ES, Bento AF, Meotti FC, Calixto JB. Activation of cannabinoid receptors by the pentacyclic triterpene alpha, beta-amyrin inhibits inflammatory and neuropathic persistent pain in mice. Pain. 2011;152: 1872-1887.
Hayami T, Pickarski M, Zhuo Y, Wesolowski GA, Rodan GA, Duong LT. Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. Bone 2006; 38: 234-243.
Wang WH, Chuang HY, Chen CH, Chen WK, Hwang JJ. Lupeol acetate ameliorates collagen-induced arthritis and osteoclastogenesis of mice through improvement of microenvironment. Biomed. Pharmacother. 2016;79: 231-240.
Singh D, Arya PV, Sharma A, Dobhal MP, Gupta RS. Modulatory potential of alpha-amyrin against hepatic oxidative stress through antioxidant status in Wistar albino rats. J. Ethnopharmacol. 2015;161: 86-193.
Sudirman S, Chen CK, Long BT, Chang HW, Tsou D, Kong ZL. Vitellaria paradoxa nut triterpene-rich extract ameliorates symptoms of iflammation on post-traumatic osteoarthritis in obese rats. J. Pain Res. 2020;2020: 261-271.
Euppayo T, Punyapornwithaya V, Chomdej S, Ongchai S, Nganvongpanit K. Effects of hyaluronic acid combined with anti-inflammatory drugs compared with hyaluronic acid alone, in clinical trials and experiments in osteoarthritis: a systematic review and meta-analysis. BMC Musculosk. Disord. 2017;18: 387.
Bove SE, Calcaterra SL, Brooker RM, Huber CM, Guzman RE, Juneau PL, Schrier DJ, Kilgore KS. Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis. Osteoarthr. Cartil. 2003;11: 821-830.
Fernihough J, Gentry C, Malcangio M, Fox A, Rediske J, Pellas T, Kidd B, Bevan S, Winter J. Pain related behaviour in two models of osteoarthritis in the rat knee. Pain. 2004;112: 83-93.
Gerwin N, Bendele AM, Glasson S, Carlson CS. The oarsi histopathology initiative-recommendations for histological assessments of osteoarthritis in the rat. Osteoarthr. Cartil. 2010;18: S24-S34. 14 (2022). Establishment of a Surgery-Induced Osteoarthritis Rat Model. British Journal of Healthcare and Medical Research, 9(1). 1-15.
Onur T, Wu R, Metz L, Dang A. Characterisation of osteoarthritis in a small animal model of type 2 diabetes mellitus. Bone Joint Res. 2014;3: 203-211.
Ikeuchi M, Izumi M, Aso K, Sugimura N, Kato T, Tani T. Effects of intra-articular hyaluronic acid injection on immunohistochemical characterization of joint afferents in a rat model of knee osteoarthritis. Eur. J. Pain. 2015;19: 334-340.
Chen IJ, Wong CS. Shea nut oil extracts enhance the intra-articular sodium hyaluronate effectiveness on surgically induced OA progression in rats. Nutrients 2020; 12: 957.
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Copyright (c) 2022 Yu-Hsing Lin, Chia-Chi Chen, Hsiao-Yun Chen, Ying-Ching Hung, Yun-Xuan Chang, Tzu-Yun Chi, Chia-Yu Lin, Guan-Hong Chen, Ping-Min Huang, Tsung-Han Wu, Yen-Jung Lu, Chien-Chao Chiu, Ching-Feng Chiu, Hsuan-Wen Chiu, Wei-Huang Tsai, Shao-Wen Hung
This work is licensed under a Creative Commons Attribution 4.0 International License.
