Relationship Between Cerebroplacental Ratio and Fetal Outcome Among Women with Preeclampsia in Irrua, Edo State, Nigeria

Authors

  • O E Olugbenga Department of Obstetrics and Gynaecology, Irrua Specialist Teaching Hospital Irrua, Edo State, Nigeria
  • M O Momoh Department of Obstetrics and Gynaecology, Irrua Specialist Teaching Hospital Irrua, Edo State, Nigeria
  • F I Omorogbe Department of Obstetrics and Gynaecology, Irrua Specialist Teaching Hospital Irrua, Edo State, Nigeria
  • G B O Okome Department of Obstetrics and Gynaecology, Irrua Specialist Teaching Hospital Irrua, Edo State, Nigeria
  • P A Isabu Department of Obstetrics and Gynaecology, Irrua Specialist Teaching Hospital Irrua, Edo State, Nigeria
  • M A Olugbenga Department of Anatomy, Ambrose Alli University, Ekpoma, Edo State, Nigeria
  • J O Eigbefoh Department of Obstetrics and Gynaecology, Irrua Specialist Teaching Hospital Irrua, Edo State, Nigeria
  • S O Alikah Neonatology unit, Department of Paediatrics and child health, Irrua Specialist Teaching Hospital Irrua, Edo State, Nigeria

DOI:

https://doi.org/10.14738/bjhr.1203.18854

Keywords:

Fetal Doppler, cerebroplacental ratio (CPR), preeclampsia, perinatal outcome

Abstract

Background: Fetal Doppler ultrasound scan has become a quick way of screening for fetal compromise and determining appropriate management in high-risk pregnancies such as preeclampsia. The role of cerebroplacental ratio for this purpose is being explored. Aim: The aim of this study is to evaluate the relationship between cerebroplacental ratio and fetal outcome among women with preeclampsia. Methodology: This prospective cohort study was among 100 consecutive women with singleton pregnancies and preeclampsia between 34weeks and 37 weeks of gestation, recruited for umbilical and middle cerebral artery Doppler with the cerebroplacental ratio (CPR) determined. Statistical analysis was performed using SPSS 23.0, with significance set at p < 0.05. Results: Among them, 19% had pathologic CPR of <1 while 81% had normal CPR. The APGAR scores were significantly lower among those with pathologic CPR in the first minute (X2꞊40.443, df꞊2, P<0.001) and fifth minute (X2꞊17.311, df꞊2, P<0.001) respectively. Out of those admitted in the special care baby unit(SCBU), 62.1% had abnormal CPR while 37.9% had normal CPR(X2꞊49.23, df꞊1, P<0.001). One intrauterine fetal death occurred in each group and of the cases of Early Neonatal Death (ENND), 5(83.3%) had abnormal CPR and 1(16.7%) had a normal CPR which was statistically significant (X2꞊14.118, df꞊2. p꞊0.001). Conclusion: A significant relationship between CPR and adverse perinatal outcome exists, in terms of low APGAR scores, SCBU admission and perinatal mortality in neonates of women with preeclampsia with no significant difference in the mode of delivery.

References

Wenda R, Asif A. Therapeutic potential of statins and the induction of heme oxygenase-1 in preeclampsia. J ReprodImmunol. 2014;101-102: 153-160.

Osungbade KO, Ige OK. Public health perspectives of preeclampsia in developing countries: Implication for health system strengthening. J Pregnancy 2011;2011:481095.

Oforma, N. H., Emmanuel, O. O., Isoken, A., Xavier, E., Governor, O., Festus, O., Anthonia, N., Joseph, E., & Theophilus, A. (2025). Prediction of Preeclampsia and Other Adverse Pregnancy Outcomes in Women of Advanced Maternal Age: The Use of Mid Trimester Uterine Artery Doppler Velocimetry. British Journal of Healthcare and Medical Research, 12(2), 120–133.

Adekanmi AJ, Roberts A, Akinmoladun JA and Adeyinka AO, Uterine and Umbilical artery Doppler in women with preeclampsia and their pregnancy outcomes. Niger. Postgrad. Med. J. 2019; 26:106-12.

Anita K, Namrata S and Deepti R. Comparison of Outcome of Normal and High-Risk Pregnancies Based Upon Cerebroplacental Ratio Assessed by Doppler Studies. J ObstetGynaecol India, 2017;67(3): 173-177.

Karlsen HO, Ebbing C, Rasmussen S, Kiserud T and Johnsen SL. Use of conditional centiles of middle cerebral artery pulsatility index and cerebroplacental ratio in the prediction of adverse perinatal outcomes, Acta Obstet. Gynaecol. Scand; 2016: 12912.

Davy D.A, MacGillivray I. The classification of hypertensive disorders of pregnancy. Am J Obstet Gynecol. 1988; 158: 175-215.

Adelodun AM, Adekanmi AJ, Roberts A, Adeyinka AO. Effect of asymptomatic malaria parasitemia on the uterine and umbilical artery blood flow impedance in third-trimester singleton Southwestern Nigerian pregnant women. Trop J ObstetGynaecol2018;35:333-41

Abdulrazak H. A, Zena Abass M. Relationship between preeclampsia umbilical blood flow and perinatal outcome. Int J. Sci and Researc Pub, 2015; 5: 12.

Gruttner B, Ratiu J, Ratiu D., Gottschalk I, Morgenstern B, Abel S et al. Correlation of Cerebroplacental Ratio (CPR) With Adverse Perinatal Outcome in Singleton Pregnancies. In Vivo. 2019;33:1703–1706.

Anand S., Mehrotra S., Singh U., Solanki V and Agarwal S. Study of Association of Fetal Cerebroplacental Ratio with Adverse Perinatal Outcome in Uncomplicated Term AGA Pregnancies. J Obstet Gynecol India 2020; 70: 485-489

Swati S, Ekele BA, Shehu CE and Nwobodo EI. Hypertensive disorder in pregnancy among pregnant women in a Nigerian Teaching Hospital. Niger. Med. J. 2014; 55(5):384-388.

Suresh KP, Chandrashekaras. Sample size Estimation and power analysis for clinical research studies. J. Human Reprodsci. 2012;5:7-13.

Acharya G, Wilsgaard T, Berntsen G, Maltau J, KiserudT.Reference ranges for serial measurements of blood velocity and pulsatility index at the intra-abdominal portion, and fetal and placental ends of the umbilical artery. Ultrasound Obstet Gynecol. 2005; 26: 162–169. 178

Flood K, Unterscheider J, Daly S, Geary MP, Kennelly MM, McAuliffe FM et al. The role of brain sparing in the prediction of adverse outcomes in intrauterine growth restriction: results of the multicenter PORTO Study. Am J Obstet Gynecol. 2014; 211:288.e1-288.e5.

Council for International organizations of Medical Sciences (CIOMS). International Ethical Guidelines for Biomedical Research Involving Human subjects, Geneva; 1993.

Ayyuba R, Abubakar IS, Yakasai IA. Umbilical artery Doppler velocimetry study on prediction of adverse pregnancy outcomes among pregnant women with hypertensive disorders in Kano, Nigeria. Niger. J. Basic. Clin. Sci. 2015;12:95-104.

Anand S., Mehrotra S., Singh U., Solanki V and Agarwal S. Study of Association of Fetal Cerebroplacental Ratio with Adverse Perinatal Outcome in Uncomplicated Term AGA pregnancies. J Obstet Gynecol India. 2020; 70: 485 -489.

M. Fiolna, V. Kostiv, C. Anthoulakis, R. Akolekar, K. H. Nicolaides, Prediction of adverse perinatal outcome by cerebroplacental ratio in women undergoing induction of labor. Ultrasound Obstet Gynecol. 2019: 53(4); 473-480.

Indiramani, Y., Ratnakumari, V, Jyothirmayi, B. Colour Doppler Study of Umbilical Artery in Antenatal Women with Severe Preeclampsia and Fetal Outcome. Open Journal of Obstetrics and Gynecology, 2016; 6:129-135.

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Published

2025-05-26

How to Cite

Olugbenga, O. E., Momoh, M. O., Omorogbe, F. I., Okome, G. B. O., Isabu, P. A., Olugbenga, M. A., … Alikah, S. O. (2025). Relationship Between Cerebroplacental Ratio and Fetal Outcome Among Women with Preeclampsia in Irrua, Edo State, Nigeria. British Journal of Healthcare and Medical Research, 12(03), 165–179. https://doi.org/10.14738/bjhr.1203.18854

Issue

Vol. 12 No. 03 (2025): British Journal of Healthcare and Medical Research

Section

Original Articles

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Copyright (c) 2025 Olugbenga, O. E., Momoh, M. O., Omorogbe, F. I., Okome, G. B. O., Isabu, P. A., Olugbenga, M. A., Eigbefoh, J. O., Alikah, S. O.

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