Molecular Genetics

The complement system is formed form a group of sera of plasma proteins found in fresh vertebrate sera. The number of these components are ranging between 30-40 components with their own receptors. Such components appeared in vertebrate at electrophoro-grames in the arcs of alpha1 , alpha2 , beta and gamma globulins. Through , components differs from immunological characteristics. Components protein are heat labile at 56c for half an hour. Complement can be activated in sequential manner of their own component with marked subunit assembly & functional units help in phagocytosis and cell lysis components system has fluid and membrane phases and a activated in three steps initiators, amplification and membrane attack. The activation is established in three pathways ; the classical , the properidin and the lectin pathways. Properidin is found in natural immunity , classical and lectin in the adaptive immunity .