Cholera

Cholera is a diarrheal syndrome of an infectious epidemic or pandemic nature. This syndrome expressed several epidemic and pandemic spread all over the world during sixties, seventies eighties and nineties of the twentieth century. Cholera caused by V. cholerae serotypes ,the known OI and non-OI serotypes.It seems to be that there were other entero-pathogen like entero-toxigenic Escherichia coli may express such diarrheal syndrome but with neither evident epidemicity nor form water diarrhea .The syndrome has been described as water and food born.It is considered as an enterotoxin induced in which the enterotoxin induce adenyl cyclase. The denyl cyclase in turn induced fluid accumulation in the affected patients gut leading to rice water diarrhea.Infected patient need ;fluid re-susstation ,quarantine and Tetracyclin R derivative therapy.Prove of V.cholerae pathogenicity in mice or other small animal mammals was through the application of the ligated ileal loop technic. The infection induced immunity may be antitoxic, anti-bacterial and vibriocidal antibody responses. Several vaccine makes are known to date that can be of use in facing the epidemic episodes in different world countries[ Holmgren 2021,Momba and Azab EL-Liethy 2017,Sakazaki et al 1970].