Genotoxicity of Xenobiotics: Revisiting

Shnawa IMS

Dhahi SJ

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  • Preface:
  • Xenobiotic holds the forefront position in the current modern and industrialized community. They gain increasing use for human welfare. As; medicine, personal pharmaceutical, antibiotics, petroleum by products, pesticide as well as microbial toxins. Markel human use of one or more of these xenobiotics accompanied by some negative impacts on his health. Such negative impacts ensemble; genotoxicity, teratogenicity, carcinogenicity and/or oncogenicity. The main theme of the present monograph has been based upon tempts to develop gene mutation lower eukaryotic genetic test system originally developed in Aspergillus nidulans and mainly adopted for detection of numerical chromosome aberrations studies. Same theme was adopted and adapted A. amstelodami to detect forward gene mutation induced by xenobiotics and be of use for detection of xenobiotic genotoxicity. The developed genetic system characterized by; 1. using haploid conidia 2. Test direct and indirect gene toxic effects 3. Test synergistic or interacted gene toxic actions. The text was organized in two parts, five sections and 18 chapters. The first part is the platform include two sections and six chapters. The second part which is the genotoxicity of xenobiotics constituting three sections and eleven chapters. The present monograph bears a series of essays concerning genotoxicity of five xenobiotics impactful on human welfare. This monograph serves genetic toxicology students, and researchers in having an insight about the genotoxicity of xenobiotics.
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Published
  • Mar 29, 2025
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  • Copyright (c) 2025 Shnawa IMS and Dhahi SJ
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This work is licensed under a Creative Commons Attribution 4.0 International License.