Identification of Novel Human Cancer-Specific Antigens

Rasha Ali Hussain Al-Khafaji
  1. Adamo, A., Montemauri, P., Silva, N., Ward, J.D., Boulton, S.J. & La Volpe, A. 2008, “BRC-1 acts in the inter-sister pathway of meiotic double-strand break repair”, EMBO Reports, vol. 9, no. 3, pp. 287-292.
  2. Adams, S., Greeder, L., Reich, E., Shao, Y., Fosina, D., Hanson, N., Tassello, J., Singh, B., Spagnoli, G., Demaria, S. & Jungbluth, A. 2011, “Expression of cancer testis antigens in human BRCA- associated breast cancers: potential targets for immunoprevention?”, CANCER IMMUNOLOGY IMMUNOTHERAPY, vol. 60, no. 7, pp. 999-1007.
  3. Afridi, S., Bano, F. & Shafiq-ur-Rahman 2011, “Pattern and Presentation of Carcinoma Stomach”, JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN, vol. 21, no. 3, pp. 161-163.
  4. Agrawal, P., Yu, K., Salomon, A. & Sedivy, J. 2010, “Proteomic profiling of Myc-associated proteins”, CELL CYCLE, vol. 9, no. 24, pp. 4908-4921.
  5. Ahn, J., Rha, S., Shin, S., Jeung, H., Kim, T., Zhang, X., Park, K., Noh, S., Roh, J. & Chung, H. 2010, “Circulating endothelial progenitor cells (EPC) for tumor vasculogenesis in gastric cancer patients”, CANCER LETTERS, vol. 288, no. 1, pp. 124-132.
  6. Akerfelt, M., Vihervaara, A., Laiho, A., Conter, A., Christians, E., Sistonen, L. & Henriksson, E.2010, “Heat Shock Transcription Factor 1 Localizes to Sex Chromatin during Meiotic Repression”, JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, no. 45, pp. 34469-34476.
  7. Akers, S., Odunsi, K. & Karpf, A. 2010, “Regulation of cancer germline antigen gene expression: implications for cancer immunotherapy”, FUTURE ONCOLOGY, vol. 6, no. 5, pp. 717-732.
  8. Albini, A., Indraccolo, S., Noonan, D.M. & Pfeffer, U. 2010, “Functional genomics of endothelial cells treated with anti-angiogenic or angiopreventive drugs”, Clinical & experimental metastasis, vol. 27, no. 6, pp. 419-439.
  9. Albrethsen, J., Knol, J.C., Piersma, S.R., Pham, T.V., de Wit, M., Mongera, S., Carvalho, B., Verheul, H.M.W., Fijneman, R.J.A., Meijer, G.A. & Jimenez, C.R. 2010a, “IDENTIFICATION OF PROTEINS ENRICHED IN THE NUCLEAR MATRIX FRACTION AND REGULATION IN ADENOMA TO CARCINOMA PROGRESSION”, Molecular & Cellular Proteomics, vol. 9, pp. 988-1005.
  10. Albrethsen, J., Knol, J.C., Piersma, S.R., Pham, T.V., de Wit, M., Mongera, S., Carvalho, B., Verheul, H.M., Fijneman, R.J., Meijer, G.A. & Jimenez, C.R. 2010b, “IDENTIFICATION OF PROTEINS ENRICHED IN THE NUCLEAR MATRIX FRACTION AND REGULATION IN ADENOMA TO CARCINOMA PROGRESSION”, Molecular & Cellular Proteomics, vol. 9, no.5, pp. 988-1005.Aldridge, R.B., Zanotto, M., Ballerini, L., Fisher, R. & Rees, J.L. 2011, “Novice Identification of Melanoma: Not Quite as Straightforward as the ABCDs”, ACTA DERMATO-VENEREOLOGICA, vol. 91, no. 2, pp. 125-130.
  11. Almstedt, M., Blagitko-Dorfs, N., Duque-Afonso, J., Karbach, J., Pfeifer, D., Jaeger, E. & Luebbert, M. 2010, “The DNA demethylating agent 5-aza-2 ‘-deoxycytidine induces expression of NY-ESO- 1 and other cancer/testis antigens in myeloid leukemia cells”, LEUKEMIA RESEARCH, vol. 34, no. 7, pp. 899-905.
  12. Andrade, M.A., Perez-Iratxeta, C. & Ponting, C.P. 2001, “Protein Repeats: Structures, Functions, and Evolution”, Journal of Structural Biology, vol. 134, pp. 117-131.
  13. Aplin, A.E., Howe, A., Alahari, S.K. & Juliano, R.L. 1998, ” Signal Transduction and Signal Modulation by Cell Adhesion Receptors: The Role of Integrins, Cadherins, Immunoglobulin-Cell Adhesion Molecules, and Selectins”, Pharmacological Reviews, vol. 50, no. 2, pp. 197-264.
  14. Aprelikova, O., Pandolfi, S., Tackett, S., Ferreira, M., Salnikow, K., Ward, Y., Risinger, J., Barrett, & Niederhuber, J. 2009, “Melanoma Antigen-11 Inhibits the Hypoxia-Inducible Factor Prolyl Hydroxylase 2 and Activates Hypoxic Response”, CANCER RESEARCH, vol. 69, no. 2, pp. 616- 624.
  15. Arencibia, J.M., Martín, S., Pérez-Rodríguez, F.J. & Bonnin, A. 2009, ” Gene expression profiling reveals overexpression of TSPAN13 in prostate cancer”, Int J Oncol., vol. 34, no. 2, pp. 457-463.
  16. Arijs, I., De Hertogh, G., Lemaire, K., Quintens, R., Van Lommel, L., Van Steen, K., Leemans, P., Cleynen, I., Van Assche, G., Vermeire, S., Geboes, K., Schuit, F. & Rutgeerts, P. 2009, ” Mucosal gene expression of antimicrobial peptides in inflammatory bowel disease before and after first infliximab treatment.”, PLoS One, vol. 4, no. 11, pp. e7984.
  17. Atanackovic, D., Luetkens, T., Hildebrandt, Y., Arfsten, J., Bartels, K., Horn, C., Stahl, T., Cao, Y., Zander, A., Bokemeyer, C. & Kroeger, N. 2009, “Longitudinal Analysis and Prognostic Effect of Cancer-Testis Antigen Expression in Multiple Myeloma”, CLINICAL CANCER RESEARCH, vol. 15, no. 4, pp. 1343-1352.
  18. Avet-Loiseau, H., Facon, T., Grosbois, B., Magrangeas, F., Rapp, M.J., Harousseau, J.L., Minvielle, S. & Bataille, R. 2002, ” Oncogenesis of multiple myeloma: 14q32 and 13q chromosomal abnormalities are not randomly distributed, but correlate with natural history, immunological features, and clinical presentation”, Blood, vol. 99, no. 6, pp. 2185-2191.
  19. Ayyoub, M., Pignon, P., Dojcinovic, D., Raimbaud, I., Old, L., Luescher, I. & Valmori, D. 2010, “Assessment of Vaccine-Induced CD4 T Cell Responses to the 119-143 Immunodominant Region of the Tumor-Specific Antigen NY-ESO-1 Using DRB1*0101 Tetramers”, CLINICAL CANCER RESEARCH, vol. 16, no. 18, pp. 4607-4615.
  20. Aziz-Seible, R.S. & Casey, C.A. 2011, “Fibronectin: Functional character and role in alcoholic liver disease”, WORLD JOURNAL OF GASTROENTEROLOGY, vol. 17, no. 20, pp. 2482-2499.
  21. Baarends, W., Laan, R. & Grootegoed, J. 2001, “
  22. DNA repair mechanisms and gametogenesis”, Reproduction, vol. 121, pp. 31-39.
  23. Baba, A. & Câtoi, C. 2007, Comparative Oncology, The Publishing House of the Romanian Academy., Romania.
  24. Bai, S. & Wilson, E.M. 2008, “Epidermal growth factor-dependent phosphorylation and ubiquitinylation of MAGE-11 regulates its interaction with the androgen receptor”, MOLECULAR AND CELLULAR BIOLOGY, vol. 28, no. 6, pp. 1947-1963.
  25. Bai, S., He, B. & Wilson, E. 2005, “Melanoma antigen gene protein MAGE-11 regulates androgen receptor function by modulating the interdomain interaction”, MOLECULAR AND CELLULAR BIOLOGY, vol. 25, no. 4, pp. 1238-1257.
  26. Bärlund, M., Monni, O., Weaver, J., Kauraniemi, P., Sauter, G., Heiskanen, M., Kallioniemi, O. & Kallioniemi, A. 2002, “Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer”, Genes Chromosomes Cancer., vol. 35, no. 4, pp. 311-317.
  27. Barry, W.T., Kernagis, D.N., Dressman, H.K., Griffis, R.J., Hunter, J.D., Olson, J.A., Marks, J.R., Ginsburg, G.S., Marcom, P.K., Nevins, J.R., Geradts, J. & Datto, M.B. 2010, ” Intratumor heterogeneity and precision of microarray-based predictors of breast cancer biology and clinical outcome.”, J Clin Oncol., vol. 28, no. 13, pp. 2198-2206.
  28. Bart, J., Groen, H.J., Graaf, W.T.v., Hollema, H., Hendrik, N.H., Vaalburge, W., Sleijferc, D.T. & GE de Vriesc, E. 2002, “An oncological view on the blood–testis barrier”, The Lancet Oncology, vol. 3, no. 6, pp. 357-363.
  29. Bates, S. 2010, “Progress towards personalized medicine”, Drug Discovery Today, vol. 15, no. 3-4, pp. 115-120
  30. Bauer, M., Su, G., Casper, C., He, R., Rehrauer, W. & Friedl, A. 2010, ” Heterogeneity of gene expression in stromal fibroblasts of human breast carcinomas and normal breast”, Oncogene., vol. 29, no. 12, pp. 1732-1740.
  31. Beier, D., Hau, P., Proescholdt, M., Lohmeier, A., Wischhusen, J., Oefner, P.J., Aigner, L., Brawanski, A., Bogdahn, U. & Beier, C.P. 2007, ” CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles”, Cancer Res., vol. 67, no. 9, pp. 4010-4015.
  32. Bellati, F., Napoletano, C., Tarquini, E., Palaia, I., Landi, R., Manci, N., Spagnoli, G., Rughetti, A., Panici, P. & Nuti, M. 2007, “Cancer testis antigen expression in primary and recurrent vulvar cancer: Association with prognostic factors”, EUROPEAN JOURNAL OF CANCER, vol. 43, no. 17, pp. 2621-2627.
  33. Bergeron, A., Picard, V., LaRue, H., Harel, F., Hovington, H., Lacombe, L. & Fradet, Y. 2009, “High frequency of MAGE-A4 and MAGE-A9 expression in high-risk bladder cancer”, INTERNATIONAL JOURNAL OF CANCER, vol. 125, no. 6, pp. 1365-1371.
  34. Bild, A.H., Yao, G., Chang, J.T., Wang, Q., Potti, A., Chasse, D., Joshi, M.B., Harpole, D., Lancaster, J.M., Berchuck, A., Olson, J.A., Marks, J.R., Dressman, H.K., West, M. & Nevins, J.R. 2006, ” Oncogenic pathway signatures in human cancers as a guide to targeted therapies”, Nature. 2006 Jan 19;439(7074):353-7., vol. 439, no. 7074, pp. 353-357.
  35. Blackburn, E. 2010, “Telomeres and telomerase: their roles in human health and disease”, ejc supplements, vol. 8, no. 5, pp. 1-3.
  36. Bogdanov, K. & Takimoto, M. 2008, “The involvement of c-Abl and D40 (AF15q14/CASC5) proteins in the regulation of cell proliferation and cancer”, Tsitologiia, vol. 50, no. 7, pp. 590-596.
  37. Boon, N.A., Colledge, N.R., Walker, B.R. & Hunter, J.A.A. (eds) 2006, Davidson’s Principles & Practice of Medicine, 20th edn, Churchill Livingston Elsevier, India.
  38. Bowles, J. & Koopman, P. 2010, “Sex determination in mammalian germ cells: extrinsic versus intrinsic factors”, REPRODUCTION, vol. 139, no. 6, pp. 943-958.
  39. Breuer, M., Kolano, A., Kwon, M., Li, C., Tsai, T., Pellman, D., Brunet, S. & Verlhac, M. 2010, “HURP permits MTOC sorting for robust meiotic spindle bipolarity, similar to extra centrosome
  40. clustering in cancer cells.”, The Journal of cell biology, vol. 191, no. 7, pp. 1251-1260.
  41. Buday, L. & Downward, J. 2008, “Many faces of Ras activation”, Biochimica et Biophysica Acta (BBA) – Reviews on Cancer, vol. 1786, no. 2, pp. 178-187.
  42. Buganim, Y., Solomon, H., Rais, Y., Kistner, D., Nachmany, I., Brait, M., Madar, S., Goldstein, I., Kalo, E., Adam, N., Gordin, M., Rivlin, N., Kogan, I., Brosh, R., Sefadia-Elad, G., Goldfinger, N., Sidransky, D., Kloog, Y. & Rotter, V. 2010, ” p53 Regulates the Ras circuit to inhibit the expression of a cancer-related gene signature by various molecular pathways.”, Cancer research, vol. 70, no. 6, pp. 2274-2284.
  43. Burbos, N., Musonda, P., Duncan, T., Crocker, S.G., Morris, E.P. & Nieto, J.J. 2011, “Estimating the Risk of Endometrial Cancer in Symptomatic Postmenopausal Women A Novel Clinical Prediction Model Based on Patients’ Characteristics”, INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, vol. 21, no. 3, pp. 500-506.
  44. Burger, R. 2011, “Overview of anti-angiogenic agents in development for ovarian cancer.”, Gynecologic oncology, vol. 121, no. 1, pp. 230-238.
  45. Cai, J., Han, S., Qing, R., Liao, D., Law, B. & Boulton, M. 2011, “In pursuit of new anti-angiogenic therapies for cancer treatment.”, Frontiers in bioscience : a journal and virtual library, vol. 16, pp. 803-814.
  46. Calcagno, D., Leal, M., Demachkic, S., Tereza, M., Araújoc, F., Freitasa, F., Souzaa, D., Assumpçãod, P., Ishakd, G., Smith, M. & Burbanoa, R. 2010, “MYC in gastric carcinoma and intestinal metaplasia of young adults”, Cancer Genetics and Cytogenetics, vol. 202, no. 1, pp. 63- 66.
  47. Calo, E., Quintero-Estades, J., Danielian, P., Nedelcu, S., Berman, S. & Lees, J. 2010, “Rb regulates fate choice and lineage commitment in vivo.”, Nature, vol. 466, no. 7310, pp. 1110-1114. Camp, N.J., Cannon-Albright, L.A., Farnham, J.M., Baffoe-Bonnie, A.B., George, A., Powell, I., Bailey-Wilson, J.E., Carpten, J.D., Giles, G.G., Hopper, J.L., Severi, G., English, D.R., Foulkes, W.D., Maehle, L., Moller, P., Eeles, R., Easton, D., Badzioch, M.D., Whittemore, A.S., OakleyGirvan, I., Hsieh, C.L., Dimitrov, L., Xu, J., Stanford, J.L., Johanneson, B., Deutsch, K., McIntosh, L., Ostrander, E.A., Wiley, K.E., Isaacs, S.D., Walsh, P.C., Thibodeau, S.N., McDonnell, S.K., Hebbring, S., Schaid, D.J., Lange, E.M., Cooney, K.A., Tammela, T.L., Schleutker, J., Paiss, T., Maier, C., Grönberg, H., Wiklund, F., Emanuelsson, M. & Isaacs, W.B. 2007, “Compelling Evidence for a Prostate Cancer Gene at 22q12.3 by the International Consortium for Prostate Cancer Genetics”, Hum Mol Genet. 2007 Jun 1;16(11):1271-8., vol. 1, no. 16, pp. 11-1271.
  48. Cappallo-Obermann, H., von Kopylow, K., Schulze, W. & Spiess, A. 2010, ” A biopsy sample reduction approach to identify significant alterations of the testicular transcriptome in the presence of Y-chromosomal microdeletions that are independent of germ cell composition”, Hum Genet., vol. 128, no. 4, pp. 421-431.
  49. Carafoli, F., Saffell, J.L. & Hohenester, E. 2008, ” Structure of the tandem fibronectin type 3 domains of neural cell adhesion molecule”, J Mol Biol., vol. 377, no. 2, pp. 524-534.
  50. Carlos Catano, J. 2010, “Eaton-Lambert myasthenic syndrome”, BIOMEDICA, vol. 30, no. 3, pp. 319- 320.
  51. Carvalho, B., Postma, C., Mongera, S., Hopmans, E., Diskin, S., van de Wiel, M.A., van Criekinge, W., Thas, O., Matthäi, A., Cuesta, M.A., Terhaar Sive Droste, J.S., Craanen, M., Schröck, E., Ylstra, B. & Meijer, G.A. 2009, “
  52. Multiple putative oncogenes at the chromosome 20q amplicon contribute to colorectal adenoma to carcinoma progression”, Gut., vol. 58, no. 1, pp. 79-89.
  53. Cebon, J. 2010, “Cancer vaccines: Where are we going?”, ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY Volume: Pages: S9-S15 Supplement: Suppl. 1 Published: MAR 2010, vol. 6, pp. S9- S15.
  54. Chalmel, F., Lardenois, A. & Primig, M. 2007, “Toward understanding the core meiotic transcriptome in mammals and its implications for somatic cancer.”, Annals of the New York Academy of Sciences, vol. 1120, pp. 1-15.
  55. Chandran, U., Ma, C., Dhir, R., Bisceglia, M., Lyons-Weiler, M., Liang, W., Michalopoulos, G., Becich, M. & Monzon, F. 2007, “
  56. Gene expression profiles of prostate cancer reveal involvement of multiple molecular pathways in the metastatic process.”, BMC Cancer. Apr 12;7:64., vol. 7, pp. 64.
  57. Chapman, M.A., Lawrence, M.S., Keats, J.J., Cibulskis, K., Sougnez, C., Schinzel, A.C., Harview, C.L., Brunet, J.P., Ahmann, G.J., Adli, M., Anderson, K.C., Ardlie, K.G., Auclair, D., Baker, A., Bergsagel, P.L., Bernstein, B.E., Drier, Y., Fonseca, R., Gabriel, S.B., Hofmeister, C.C., Jagannath, S., Jakubowiak, A.J., Krishnan, A., Levy, J., Liefeld, T., Lonial, S., Mahan, S., Mfuko, B., Monti, S., Perkins, L.M., Onofrio, R., Pugh, T.J., Rajkumar, S.V., Ramos, A.H., Siegel, D.S., Sivachenko, A., Stewart, A.K., Trudel, S., Vij, R., Voet, D., Winckler, W., Zimmerman, T., Carpten, J., Trent, J., Hahn, W.C., Garraway, L.A., Meyerson, M., Lander, E.S., Getz, G. & Golub, T.R. 2011, ” Initial genome sequencing and analysis of multiple myeloma”, Nature. 2011 Mar 24;471(7339):467-72., vol. 471, no. 7339, pp. 467-472.
  58. Chaudhuri, D., Suriano, R., Mittelman, A. & Tiwari, R.K. 2009, “Targeting the Immune System in Cancer”, CURRENT PHARMACEUTICAL BIOTECHNOLOGY, vol. 10, no. 2, pp. 166-184.
  59. Chen, G.I., Tisayakorn, S., Jorgensen, C., D’Ambrosio, L.M., Goudreault, M. & Gingras, A.C. 2008, “PP4R4/KIAA1622 Forms a Novel Stable Cytosolic Complex with Phosphoprotein Phosphatase 4”, J Biol Chem., vol. 283, no. 43, pp. 29273-29284.
  60. Chen, M. & McLeskey, S.W. 2010, “Telomere-Based Cancer Treatment: Emerging Targeted Therapies”, CLINICAL JOURNAL OF ONCOLOGY NURSING, vol. 14, no. 6, pp. 720-726.
  61. Chen, X., Leung, S.Y., Yuen, S.T., Chu, K.M., Ji, J., Li, R., Chan, A.S., Law, S., Troyanskaya, O.G.,., Wong, J., So, S., Botstein, D. & Brown, P.O. 2003, ” Variation in gene expression patterns in human gastric cancers”, Mol Biol Cell. 2003 Aug;14(8):3208-15, vol. 14, no. 8, pp. 3208-3215.
  62. Chen, Y. Ross, D. S., Chiu, R., Zhou, X., Chen, Y., Lee, P., Hoda, S., Simpson, A., Old, L., Caballero, O. & Neville, A.M. 2011, “Multiple Cancer/Testis Antigens Are Preferentially Expressed in Hormone-Receptor Negative and High-Grade Breast Cancers”, PLOS ONE, vol. 6, no. 3, pp. e17876.
  63. Cheng, S., Ng, M.H.L., Lau, K.M., Liu, H.S.Y., Chan, J.C.W., Hui, A.B.Y., Lo, K.W., Jiang, H., Hou, J., Chu, R.W., Wong, W.S., Chan, N.P.H. & Ng, H.K. 2007, ” 4q loss is potentially an important genetic event in MM tumorigenesis: identification of a tumor suppressor gene regulated by promoter methylation at 4q13.3, platelet factor”, Blood, vol. 109, no. 5, pp. 2089-2099.
  64. Chiriva-Internati, M., Cobos, E., Da Silva, D.M. & Kast, W.M. 2008, “Sperm fibrous sheath proteins: a potential new class of target antigens for use in human therapeutic cancer vaccines”, Cancer Immun., vol. 8, pp. 8.
  65. Chiriva-Internati, M., Gagliano, N., Donetti, E., Costa, F., Grizzi, F., Franceschini, B., Albani, E., Levi-Setti, P.E., Gioia, M., Jenkins, M., Cobos, E. & Kast, W.M. 2009, ” Sperm protein 17 is expressed in the sperm fibrous sheath”, Journal of Translational Medicine 2009, 7:61, vol. 7, pp. 61.
  66. Chiriva-Internati, M., Yu, Y., Mirandola, L., Jenkins, M., Chapman, C., Cannon, M., Cobos, E. & Kast, W.M. 2010, “Cancer Testis Antigen Vaccination Affords Long-Term Protection in a Murine Model of Ovarian Cancer”, PLOS ONE, vol. 5, no. 5, pp. e10471.
  67. Choi, Y.L., Bocanegra, M., Kwon, M.J., Shin, Y.K., Nam, S.J., Yang, J.H., Kao, J., Godwin, A.K. & Pollack, J.R. 2010, ” LYN is a mediator of epithelial-mesenchymal transition and a target of dasatinib in breast cancer”, Cancer Res., vol. 70, no. 6, pp. 2296-2306.
  68. Chow, A. 2010, “Cell Cycle Control by Oncogenes and Tumor Suppressors: Driving the Transformation of Normal Cells into Cancerous Cells”, Transformation of Normal Cells into Cancerous Cells. Nature Education, vol. 3, no. 9, pp. 7.
  69. Chuang, S., La Vecchia, C. & Boffetta, P. 2009, “Liver cancer: Descriptive epidemiology and risk factors other than HBV and HCV infection”, CANCER LETTERS, vol. 286, no. 1, pp. 9-14.
  70. Chuaqui, R.F., Bonner, R.F., Best, C.J.M., Gillespie, J.W., Flaig, M.J., Hewitt, S.M., Phillips, J.L., Krizman, D.B., Tangrea, M.A., Ahram, M., Linehan, W.M., Knezevic, V. & Emmert-Buck, M.R. 2002, ” Post-analysis follow-up and validation of microarray experiment”, nature genetics supplement, vol. 32, no. 509, pp. 514.
  71. Clark, R., An, J., Greiling, D., Khan, A., Schwarzbauer, J. & Schwarzbauer, J. 2003, “Fibroblast migration on fibronectin requires three distinct functional domains”, JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 121, no. 4, pp. 695-705.
  72. Clarke, R. 2010, “Stem cells and cancer: treatment resistance, markers and novel therapeutic targets”, European Journal of Cancer Supplements, vol. 8, no. 3, pp. 183-183.
  73. Cleeland, C.S., Fisch, M.J. & Dunn, A.J. 2010, Cancer Symptom Science : Measurement, Mechanisms, and Management, N/A edn, Cambridge University Press.
  74. Coleman, R., Lipton, A., Roodman, G.D., Guise, T., Boyce, B., Brufsky, A., Clezardin, P., Croucher, P., Gralow, J., Hadji, P., Holen, I., Mundy, G.R., Smith, M.R. & Suva, L.J. 2010, “Metastasis and bone loss: Advancing treatment and prevention”, CANCER TREATMENT REVIEWS, vol. 36, no. 8, pp. 615-620.
  75. Coletta, A., Pinney, J.W., Solís, D., Marsh, J., Pettifer, S.R. & Attwood, T.K. 2010, ” Low-complexity regions within protein sequences have position-dependent roles”, BMC Systems Biology, [Online], vol. 4, , pp. 11/10/2011. Available from: [11/10/2011].
  76. Colin, P., Koenig, P., Ballereau, C., Phe, V., Berthon, N., Villers, A., Biserte, J. & Roupret, M. 2010, “Sporadic upper urinary tract urothelial cell carcinomas: identification of interaction between toxic carcinogens and individuals genetic susceptibility]”, Prog Urol, vol. 20, no. 1, pp. 1-10.
  77. Coral, S., Sigalotti, L., Altomonte, M., Engelsberg, A., Colizzi, F., Cattarossi, I., Maraskovsky, E., Jager, E., Seliger, B. & Maio, M. 2002, “5-aza-2′-deoxycytidine-induced expression of functional cancer testis antigens in human renal cell carcinoma: immunotherapeutic implications.”, Clin Cancer Res, vol. 8, no. 8, pp. 2690-2695.
  78. Costa, F., Le blanc, K. & Bertha, B. 2007, ” Concise Review: Cancer/Testis Antigens, Stem Cells, and Cancer”, STEMCELLS, vol. 25, pp. 707-711.
  79. Cressman, V., Backlund, D., Avrutskaya, A., Leadon, S., Godfrey, V. & Koller, B. 1999, “Growth retardation, DNA repair defects, and lack of spermatogenesis in BRCA1-deficient mice”, MOLECULAR AND CELLULAR BIOLOGY, vol. 19, no. 10, pp. 7061-7075.
  80. Crowder, R.J., Phommaly, C., Tao, Y., Hoog, J., Luo, J., Perou, C.M., Parker, J.S., Miller, M.A., Huntsman, D.G., Lin, L., Snider, J., Davies, S.R., Olson, J.A., Jr, W., M.A., Saporita, A., Weber, J.D. & Ellis, M.J. 2009, ” PIK3CA and PIK3CB inhibition produce synthetic lethality when combined with estrogen deprivation in estrogen receptor-positive breast cancer”, Cancer Res., vol. 69, no. 9, pp. 3955- 3962.
  81. Csoka, A.B. & Szyf, M. 2009, “Epigenetic side-effects of common pharmaceuticals: A potential new field in medicine and pharmacology”, Medical Hypotheses, vol. 73, no. 5, pp. 770-780.
  82. Cuello, M.A., Kato, S., D´ıaz1, D. & Owen, G.I. 2010, “Leptin increases the invasiveness and angiogenesis-mediated but not proliferation in human epithelial ovarian cancer cells”, European Journal of Cancer Supplements, vol. 8, no. 5, pp. 141-142.
  83. Cuffel, C., Rivals, J., Zaugg, Y., Salvi, S., Seelentag, W., Speiser, D., Lienard, D., Monnier, P., Romero, P., Bron, L. & Rimoldi, D. 2011, “Pattern and clinical significance of cancer-testis gene expression in head and neck squamous cell carcinoma”, INTERNATIONAL JOURNAL OF CANCER, vol. 128, no. 11, pp. 2625-2634.
  84. Dakshinamurthy, A.G., Ramesar, R., Goldberg, P. & Blackburn, J.M. 2008, ” Infrequent and low expression of cancer-testis antigens located on the X chromosome in colorectal cancer: Implications for immunotherapy in South African populations”, Biotechnology Journal, vol. 3, no. 11, pp. 1417-1423.
  85. Daniel, V.C., Marchionni, L., Hierman, J.S., Rhodes, J.T., Devereux, W.L., Rudin, C.M., Yung, R., Parmigiani, G., Dorsch, M., Peacock, C.D. & Watkins, D.N. 2009, ” A primary xenograft model of small-cell lung cancer reveals irreversible changes in gene expression imposed by culture in vitro”, Cancer Res. 2009 Apr 15;69(8):3364-73., vol. 69, no. 8, pp. 3364-3373.
  86. Davis, I. & Cebon, J.S. 2011, “Developing cancer immunotherapies”, ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, vol. 7, pp. 9-13.
  87. Dennis, J.W., Nabi, I.R. & Demetriou, M. 2009, “Metabolism, Cell Surface Organization, and Disease”, Cell, vol. 139, no. 7, pp. 1229-1241.
  88. Deshpande, N., Pysz, M.A. & Willmann, J.K. 2010, “Molecular ultrasound assessment of tumor angiogenesis”, Angiogenesis, vol. 13, no. 2, pp. 175-188.
  89. Diaz-Sanchez, A., Angel Lara, M., Ortega, P., Aramendi, T., Gonzalez, C., Alberdi, J., Del Valle, E., Casado, I., Campos, R. & Aldeguer, M. 2011, ” Colorectal melanoma: review of two distinct forms of presentation”, GASTROENTEROLOGIA Y HEPATOLOGIA, vol. 34, no. 2, pp. 83-88.
  90. Domagala, A. & Kurpisz, M. 2004, “Identification of sperm immunoreactive antigens for immunocontraceptive purposes: a review”, Reprod Biol Endocrinol, vol. 2, pp. 11.
  91. Domanska, K., Malander, S., Staaf, J., Karlsson, A., Borg, A., Jönsson, G. & Nilbert, M. 2010, ” Genetic profiles distinguish different types of hereditary ovarian cancer.”, Oncol Rep., vol. 24, no. 4, pp. 885-895.
  92. Döme, B., Hendrix, M., Paku, S., Tóvári, J. & Tímár, J. 2007, “Alternative Vascularization Mechanisms in Cancer: Pathology and Therapeutic Implications”, The American Journal of Pathology, vol. 170, no. 1, pp. 1-15.
  93. Domea, B., Timar, J., Ladanyi, A., Paku, S., Renyi-Vamosa, F., Klepetko, W., Lange, G., Domef, P., Bogos, K. & Tovari, J. 2009, ” Circulating endothelial cells, bone marrow-derived endothelial progenitor cells and proangiogenic hematopoietic cells in cancer: From biology to therapy”, Critical Reviews in Oncology/Hematology, vol. 69, pp. 108-124.
  94. Doñate, F., Juarez, J.C., Burnett, M.E., Manuia, M.M., Guan, X., Shaw, E.L., Smith, P., Timucin, C., Braunstein, M.J., Batuman, O.A. & Mazar, A.P. 2008, “Identification of biomarkers for the antiangiogenic and antitumour activity of the superoxide dismutase 1 (SOD1) inhibitor tetrathiomolybdate (ATN-224)”, British Journal of Cancer (2008) 98, 776–783, vol. 98, pp. 776- 783.
  95. Doolittle, R.F. 1995, ” THE MULTIPLICITY OF DOMAINS IN PROTEIN”, Annual Rev. Biochem., vol. 64, pp. 287- 314.
  96. Dragani, T.A., Hirohashi, S., Juji, T., Kawajiri, K., Kihara, M., Ono-Kihara, M., Manenti, G., Nomoto, T., Sugimura, H., Genka, K., Yokota, J., Takahashi, T., Mitsudomi, T. & Nagao, M. 2000, ” Population-based mapping of pulmonary adenoma susceptibility 1 locus”, Cancer Res. 2000 Sep 15;60(18):5017-20, vol. 60, no. 18, pp. 5017-5020.
  97. Drummond, A.J., Ashton, B., Buxton, S., Cheung, M., cooper, A., Duran, C., Field, M., Heled, J., Kearse, M., Markowitz, S., Moir, R., Stones-Havas, S., Sturrock, S., Thierer, T. & Wilson, A. 2011, geneious v5.4, Biomatters Ltd.
  98. Ellisa, H. 2007, “Anatomy of the pancreas”, Surgery (Oxford), vol. 25, no. 2, pp. 72-73.
  99. Emens, L. 2010, “Chemoimmunotherapy”, CANCER JOURNAL, vol. 16, no. 4, pp. 295-303.
  100. Erenpreisa, J. & Cragg, M.S. 2010, “MOS, aneuploidy and the ploidy cycle of cancer cells.”, Oncogene, vol. 29, no. 40, pp. 5447-5451.
  101. Ezeh, U.I.O. 2000, “Beyond the clinical classification of azoospermia: Opinion”, Human Reproduction, vol. 15, no. 11, pp. 2356-2359.
  102. Fagin, J.A. 2008, “Molecular pathology of thyroid cancer: diagnostic and clinical implications”, Best Practice & Research Clinical Endocrinology & Metabolism, vol. 22, no. 6, pp. 955-969.
  103. Feig, C., Kirchhoff, C., Ivell, R., Naether, O., Schulze, W. & Spiess, A. 2007, “A new paradigm for profiling testicular gene expression during normal and disturbed human spermatogenesis”, Mol Hum Reprod., vol. 13, no. 1, pp. 33-43.
  104. Ferlay, J., Shin, H., Bray, F., Forman, D., Mathers, C. & Maxwell Parkin, D. 2010, “Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008”, International Journal of Cancer, vol. 127, pp. 2893-2917.
  105. Finaz, C. & Hammami-Hamza, S. 2000, “Adhesion proteins expressed on human gamete surfaces and egg activation”, Biology of the Cell, vol. 92, no. 3-4, pp. 235-244.
  106. Font, C., Vidal, L., Espinosa, G., Tassies, D., Monteagudo, J., Farrus, B., Visa, L., Cervera, R., Gascon, P. & Reverter, J.C. 2011, “Solid cancer, antiphospholipid antibodies, and venous thromboembolism”, AUTOIMMUNITY REVIEWS, vol. 10, no. 4, pp. 222-227.
  107. Frattaa, E., Corala, S., Covrea, A., Parisia, G., Colizzia, F., Daniellia, R., Nicolaya, H.J.M., Sigalottia, L. & Maioa, M. 2011a, “The biology of cancer testis antigens: Putative function, regulation and therapeutic potential”, [Online], . Available from: http://0-
  108. Frattaa, E., Corala, S., Covrea, A., Parisia, G., Colizzia, F., Daniellia, R., Nicolaya, H., Sigalottia, L. & Maioa, M. 2011b, “The biology of cancer testis antigens: Putative function, regulation and therapeutic potential”, .
  109. Frezzetti, D., Menna, M., Zoppoli, P., Guerra, C., Ferraro, A., Bello, A.M., Luca, P.D., Calabrese, C., Fusco, A., Ceccarelli, M., Zollo, M., Barbacid, M., Lauro, R.D. & Vita, G.D. 2011, “Upregulation of miR-21 by Ras in vivo and its role in tumor growth”, Oncogene, vol. 30, no. 3, pp. 275-286.
  110. Fuldaa, S. & Pervaiz, S. 2010, “Apoptosis signaling in cancer stem cells”, The International Journal of Biochemistry & Cell Biology, vol. 42, pp. 31-38.
  111. Ganza, P. 2010, “Harnessing personalised medicine to prevent late effects”, The Lancet, vol. 11, no. 1, pp. 7-9.
  112. Gaudernack, G. 2006, “Prospects for vaccine therapy for pancreatic cancer “, Best Practice & Research Clinical Gastroenterology, vol. 20, no. 2, pp. 299-314.
  113. Gebhard, C., Schwarzfischer, L., Pham, T.H., Schilling, E., Klug, M., Andreesen, R. & Rehli, M. 2006, ” Genome-wide profiling of CpG methylation identifies novel targets of aberrant hypermethylation in myeloid leukemia”, Cancer Res., vol. 66, no. 15, pp. 6118-6128.
  114. Gemini Bio-Product , Trypsin-EDTA Solution [Homepage of Gemini Bio-Product company], [Online]. Available: [2011, 16/09].
  115. Gerhardt, A., Usener, D., Keese, M., Sturm, J., Schadendorf, D. & Eichmüller, S. 2004, “Tissue expression and sero-reactivity of tumor-specific antigens in colorectal cancer “, Cancer Letters, vol. 208, no. 2, pp. 197-206.
  116. Ghafouri-Fard, S. & Modarressi, M. 2009, ” Cancer-Testis Antigens: Potential Targets for Cancer Immunotherapy”, Archives of Iranian Medicine, vol. 12, no. 4, pp. 395-404.
  117. Gibbs, J.R., van der Brug, M.P., Hernandez, D.G., Traynor, B.J., Nalls, M.A., Lai, S.L., Arepalli, S., Dillman, A., Rafferty, I.P., Troncoso, J., Johnson, R., Zielke, H.R., Ferrucci, L., Longo, D.L., Cookson, M.R. & Singleton, A.B. 2010, ” Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain”, PLoS Genet., vol. 6, no. 5, pp. e1000952.
  118. Gjerstorff, M., Besir, H., Larsen, M. & Ditzel, H. 2010, “Expression, purification and characterization of the cancer-germline antigen GAGE12I: A candidate for cancer immunotherapy”, PROTEIN EXPRESSION AND PURIFICATION, vol. 73, no. 2, pp. 217-222.
  119. Gjerstorff, M., Burns, J. & Ditzel, H. 2010, “Cancer-germline antigen vaccines and epigenetic enhancers: future strategies for cancer treatment”, EXPERT OPINION ON BIOLOGICAL THERAPY, vol. 10, no. 7, pp. 1061-1075.
  120. Gjerstorff, M. & Ditzel, H. 2008, ” An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members”, Tissue Antigens, vol. 71, pp. 187-192.
  121. Goh, A., Coffill, C., R. & Lane, D. 2011, “The role of mutant p53 in human cancer.”, The Journal of pathology, vol. 223, no. 2, pp. 116-126.
  122. Goon, P.K.Y., Lip, G.Y.H., Boos, C.J., Stonelake, P.S. & Blann, A.D. 2006, “Circulating Endothelial Cells, Endothelial Progenitor Cells, and Endothelial Microparticles in Cancer”, Neoplasia, vol. 8, no. 2, pp. 79-88.
  123. Gordan, J.D., Lal, P., Dondeti, V.R., Letrero, R., Parekh, K.N., Oquendo, C.E., Greenberg, R.A., Flaherty, K.T., Rathmell, W.K., Keith, B., Simon, M.C. & Nathanson, K.L. 2008, ” HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma”, Cancer Cell., vol. 14, no. 6, pp. 435-446.
  124. Gravier, E., Pierron, G., Vincent-Salomon, A., Gruel, N., Raynal, V., Savignoni, A., De Rycke, Y., Pierga, J.Y., Lucchesi, C., Reyal, F., Fourquet, A., Roman-Roman, S., Radvanyi, F., Sastre-Garau, X., Asselain, B. & Delattre, O. 2010, ” A prognostic DNA signature for T1T2 node-negative breast cancer patients”, Genes Chromosomes Cancer., vol. 49, no. 12, pp. 1125-1134.
  125. Greshock, J., Bachman, K.E., Degenhardt, Y.Y., Jing, J., Wen, Y.H., Eastman, S., McNeil, E., Moy, C., Wegrzyn, R., Auger, K., Hardwicke, M.A. & Wooster, R. 2010, ” Molecular target class is predictive of in vitro response profile”, Cancer Res., vol. 1, no. 70, pp. 3677-3686.
  126. Grichnik, J. 2006, “Genomic instability and tumor stem cells”, JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 126, no. 6, pp. 1214-1216.
  127. Grizzi, F., Franceschini, B., Hamrick, C., Frezza, E., Cobos, E. & Chiriva-Internati, M. 2007, “Usefulness of cancer-testis antigens as biomarkers for the diagnosis and treatment of hepatocellular carcinoma”, Journal of Translational Medicine, vol. 5, no. 3.
  128. Guo, J., Zhu, P., Wu, C., Yu, L., Zhao, S. & Gu, X. 2003, “In silico analysis indicates a similar gene expression pattern between human brain and testis”, CYTOGENETIC AND GENOME RESEARCH, vol. 103, no. 1-2, pp. 58-62.
  129. Gutierrez, A., Sanda, T., Ma, W., Zhang, J., Grebliunaite, R., Dahlberg, S., Neuberg, D., Protopopov, A., Winter, S.S., Larson, R.S., Borowitz, M.J., Silverman, L.B., Chin, L., Hunger, S.P., Jamieson, C., Sallan, S.E. & Look, A.T. 2010, ” Inactivation of LEF1 in T-cell acute lymphoblastic leukemia.”, Blood., vol. 115, no. 14, pp. 2845- 2851.
  130. Gutiérrez, N.C., Ocio, E.M., de Las Rivas, J., Maiso, P., Delgado, M., Fermiñán, E., Arcos, M.J., Sánchez, M.L., Hernández, J.M. & San Miguel, J.F. 2007, ” Gene expression profiling of B lymphocytes and plasma cells from Waldenström’s macroglobulinemia: comparison with expression patterns of the same cell counterparts from chronic lymphocytic leukemia, multiple myeloma and normal individuals”, Leukemia, vol. 21, no. 3, pp. 541-549.
  131. Guttery, D.S., Shaw, J.A., Lloyd, K., Pringle, J.H. & Walker, R.A. 2010, “Expression of tenascin-C and its isoforms in the breast”, CANCER AND METASTASIS REVIEWS, vol. 29, no. 4, pp. 595- 606.
  132. Haber, S. & Haber, J.M. 2011, “Malignant Mesothelioma: A Clinical Study of 238 Cases”, INDUSTRIAL HEALTH, vol. 49, no. 2, pp. 166-172.
  133. Hanahan, D. & Weinberg, R. 2011, “Hallmarks of Cancer: The Next Generation”, Cell, vol. 144, no. 5, pp. 646-674.
  134. Hanahan, D. & Weinberg, R. 2000, ” The Hallmarks of Cancer”, Cell, vol. 100, pp. 57-70.
  135. Hartikainen, J.M., Tuhkanen, H., Kataja, V., Eskelinen, M., Uusitupa, M., Kosma, V. & Mannermaa, A. 2006, ” Refinement of the 22q12-q13 Breast Cancer–Associated Region: Evidence ofTMPRSS6 as a Candidate Gene in an Eastern Finnish Population”, Clin Cancer Res, vol. 12, pp. 1454.
  136. Hassan, M.S., Ansari, J., Spooner, D. & Hussain, S. 2010, “Chemotherapy for breast cancer (Review)”, ONCOLOGY REPORTS, vol. 24, no. 5, pp. 1121-1131.
  137. Hayashida, T., Takahashi, F., Chiba, N., Brachtel, E., Jinno, H., Kitagawa, Y., Sgroi, D. & Maheswaran, S. 2010, “HOXB9, a gene overexpressed in breast cancer, induces angiogenesis, invasion, and lung metastasis”, European Journal of Cancer Supplements, vol. 8, no. 3, pp. 124
  138. Hendrix, N.D., Wu, R., Kuick, R., Schwartz, D.R., Fearon, E.R. & Cho, K.R. 2006, ” Fibroblast growth factor 9 has oncogenic activity and is a downstream target of Wnt signaling in ovarian endometrioid adenocarcinomas”, Cancer Res., vol. 66, no. 3, pp. 1354-1362.
  139. Hinoue, T., Weisenberger, D.J., Lange, C.P., Shen, H., Byun, H.M., Van Den Berg, , Malik, S., Pan, F., Noushmehr, H., van Dijk, C.M., Tollenaar, R.A. & Laird, P.W. 2011, ” Genome-scale analysis of aberrant DNA methylation in colorectal cancer”, Genome Res, , pp. Published in Advance. Hocking, D.C., Sottile, J. & McKeown-Longo, P.J. 1994, ” Fibronectin‘s 111-1 Module Contains a Conformation-dependent Binding Site for the Aminoterminal Region of Fibronectin”, T H E JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 269, no. 29, pp. 19183-19191.
  140. Hofmann, O., Caballero, O., Stevenson, B., Chen, Y., Cohen, z., Chua, R., Maher, C., Panji, S., Schaefer, U., Kruger, A., Lehvaslaiho, M., Carninci, P., Hayashizaki, Y., Jongeneel, V., Simpson, A., Old, L. & Hide, W. 2008, “Genome-wide analysis of cancer/testis gene expression”, PNAS, vol. 105, no. 51, pp. 20422-20427.
  141. Holcomb, I.N., Young, J.M., Coleman, I.M., Salari, K., Grove, D.I., Hsu, L., True, L.D., Roudier, M.P., Morrissey, C.M., Higano, C.S., Nelson, P.S., Vessella, R.L. & Trask, B.J. 2009, ” Comparative analyses of chromosome alterations in soft-tissue metastases within and across patients with castration-resistant prostate cancer”, Cancer Res., vol. 69, no. 19, pp. 7793-7802.
  142. Holmes, M.V., Shah, T., Vickery, C., Smeeth, L. & Hingorani, A. 2009, “Fulfilling the Promise of Personalized Medicine? Systematic Review and Field Synopsis of Pharmacogenetic Studies”, PLoS One, vol. 4, no. 12, pp. e7960. Hong, L., Li, S., Han, Y., Du, J., Zhang, H., Li, J., Zhao, Q., Wu, K. & Fan, D. 2011, “Angiogenesisrelated molecular targets in esophageal cancer.”, Expert opinion on investigational drugs, vol. 20, no. 5, pp. 637-644.
  143. Hou, Q., Wu, Y.H., Grabsch, H., Zhu, Y., Leong, S.H., Ganesan, K., Cross, D., Tan, L.K., Tao, J., Gopalakrishnan, V., Tang, B.L., Kon, O.L. & Tan, P. 2008, ” Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancer”, Cancer Res., vol. 68, no. 12, pp. 4623-4630.
  144. Hsu, W.L., Chen, J.Y., Chien, Y.C., Liu, M.Y., You, S.L., Hsu, M.M., Yang, C.S. & Chen, C.J. 2009, ” Independent effect of EBV and cigarette smoking on nasopharyngeal carcinoma: a 20-year followup study on 9,622 males without family history in Taiwan”, Cancer Epidemiol Biomarkers Prev., vol. 18, no. 4, pp. 1218-1226.
  145. Huang, R. & Chen, G. 2011, “Cigarette smoking, cyclooxygenase-2 pathway and cancer”, BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, vol. 1815, no. 2, pp. 158-169.
  146. Hunder, N., Wallen, H., Cao, J., Hendricks, D., Reilly, J., Rodmyre, R., Jungbluth, A., Gnjatic, S., Thompson, J. & Yee, C. 2008, ” Treatment of Metastatic Melanoma with Autologous CD4+ T Cells against NY-ESO-1″, The new england journal of medicine, vol. 358, pp. 2698.-2703
Identification of Novel Human Cancer-Specific Antigens