Effects of Biophotonic Treatment on Hematologic and Metabolic Parameters
DOI:
https://doi.org/10.14738/aivp.121.16216Keywords:
Diabetes, Hemoglobin A1c, Oxygen saturation, BiophotonicsAbstract
The wide-ranging effects of healthful vs. damaging consequences of UV irradiation on key physiologic parameters are reviewed in this paper. The effects are dependent on the wavelengths encountered, the absolute intensity and duration of the exposure, the tissues exposed, and whether the UV effects were delivered via in vivo or as an extracorporeal exposure in vitro typically performed with freshly obtained heparinized aliquots of whole blood. While damaging effects of high UV intensity may include irreversible irradiation damage to key cellular and molecular components, controlled low dosages of UV irradiation delivered via a conventional biophotonic apparatus at specific, controlled wavelengths can deliver beneficial effects on blood oxygenation, tissue repair, immune responses, glycemic responses, and glycated hemoglobin (HbA1c) concentrations. HbA1c is an important diagnostic marker for the effectiveness of diabetes management. Studies reviewed demonstrate increases in blood oxygenation and corresponding decreases in HbA1c concentrations following nominal biophotonic treatment and indicate that the application of this therapy extends beyond its more commonly applied applications in the treatment and control of infectious illnesses and anti-aging biophotonic therapeutics.
References
Frysh, P. Sun source of photons: Sunlight and Your Health. WebMD, Feb 22,2022
Krasnovsky A Jr., Drozdova, N N, Ya, V. et al. Biophotonics of molecular oxygen: activation efficiencies upon direct and photosensitized excitation. Chin. Opt. Lett. 3, S1-S4 (2005)2022). https://doi.org/10.1186/s43593-022-00029-9
Hockberger, P.E. A history of ultraviolent photobiology for humans, animals, and microorganisms. Photochem Photobiol 2002.:76: 561-579.doi:10.1562/0031-8655(2002) 0760561AHOUPF2.0.CO2
Sadraeian, M., Zhang, L., Aavani, F. et al. Viral inactivation by light. eLight 2, 18 (2022). https://doi.org/10.1186/s43593-022-00029-9.
Orien L. Tulp1,2 and George P. Einstein1,2 Efficacy of Biophotonics as a Therapeutic Adjunct in Resolving Microbial and Viral Infectious Illnesses [preprint]Sept 26, 2023. Tulp, O.L. Efficacy of Biophotonics as a Therapeutic Adjunct in Resolving Microbial and Viral Infectious Illnesses. Preprints 2023, 2023091794. https://doi.org/10.20944/preprints202309.1794.v1
Asimov, M M et al. Biophotonics of new optical method of regulating oxygen concentration in biological tissue2. 011 11th International Conf. Publisher: IEEE. 2011.
Krasnovsky Jr., N. N. Drozdova, Ya. V. Roumbal, A. V. Ivanov, and R. V. Ambartzumian, Biophotonics of molecular oxygen: activation efficiencies upon direct and photosensitized excitation, Chin. Opt. Lett. 3, S1-S4 (2005)
Pan L, Wang X, Yang S et al. Ultraviolent irradiation dependent fluorescence enhancement of hemoglobin catalyzed by reactive oxygen species. PLos ONE 2012:7)8): e44142. Doi 10.1371/journal. pone 0044142
Reeder, B J, Svistunenko, DA, Cooper, CE et al. The radical and redox chemistry of myoglobin and hemoglobin: from in vitro studies to human pathology. Antioxidant Redox Sign1004.6(6):954-966. Doi 10.1089/ars.2004.6.954.
Liebert L., Capon, W., Pang, V.,et al. Photophysical Mechanisms of Photobiomodulation Therapy as Precision Medicine. Biomedicines. 2023 Feb; 11(2): 237. doi: 10.3390/biomedicines11020237. PMCID: PMC9953702 PMID: 36830774
Samaja M, Melotti, D Carenini, A et al. Glycosylated hemoglobins and the oxygen affinity of whole blood. Diabetologia 1982:23(5):399-402.doi10.1—7/bf00260950
Patwardhan, R.S., Checker, R, Sharma, D, et al. Involvement of ERK-Nrf-2 signaling in ionizing radiation induced cell death in normal and tumor cells. PLoS One. 2013 Jun 11;8(6): e65929. doi: 10.1371/journal.pone.0065929. Print 2013. PMID: 23776571. PMCID: PMC3679038 *
Tuieng, R. J., Cartmell, S.H., , Kirwan, C.C., and Sherratt, M.J. The Effects of Ionising and Non-Ionising Electromagnetic Radiation on Extracellular Matrix Proteins. Cells. 2021 Nov; 10(11): 3041. doi: 10.3390/cells10113041. PMCID: PMC8616186. PMID: 34831262
Rowen, R J. Ultraviolent blood irradiation therapy; the cure that time forgot. Int J Biosocial Med Research. vol 14(2) 115-132. 1996.
Miley, G. Ultra-violet blood therapy in acute pyogenic infections. In: Proceedings of local branches of the American Societies for bacteriologists, Eastern Pennsylvania Section, 1943. J. Bacteriol 1943; 45(3):303-https://jb.asm.org/content/45/3/303
Tulp, O L and Einstein, G.P. Efficacy of Biophotonics as a Therapeutic Adjunct in Resolving Microbial and Viral Infectious Illnesses. Preprints 2023, 2023091794. Https://doi.org/10.20944/preprints202309.1794.v1
Einstein, G. P., Echavarria, L and Tulp, O L.; Application of Einstein Matrix Medical Treatment for HIV/HCV therapy; The FASEB Journal, April 2021 (668.4). Faseb J 27(S1)
Zipper, L M and McCulhay, R T. Erk Activation Is Required for Nrf2 Nuclear Localization during Pyrrolidine Dithiocarbamate Induction of Glutamate Cysteine Ligase Modulatory Gene Expression in HepG2 Cells. Toxicological Sciences, Volume 73, Issue 1, May 2003, Pp 124–134, https://doi.org/10.1093/toxsci/kfg083
Perutz, Max F., et al. Identification of residues contributing to the Bohr effect of human haemoglobin." Journal of molecular biology 138.3 (1980): 649-668.
Webb AR, DeCosta BR, Holick MF. Sunlight regulates the cutaneous production of vitamin D3 by causing its photodegradation. Journal of Clinical Endocrinology and Metabolism. 1989;68(5):882–887 1 1 1 2,3 1 3
Ilyas Saytashev, Rachel Glenn, Gabrielle A. Murashova, Sam Osseiran, Dana Spence, Conor L. Evans, and 1,4,* Marcos Dantus Multiphoton excited hemoglobin fluorescence and third harmonic generation for noninvasive microscopy of stored blood. [Biomed Opt Express. 2016 Sep 1; 7(9): 3449–3460. 2016 Aug 12. doi: 10.1364/BOE.7.003449 PMCID: PMC5030023 PMID: 27699111
Bently, R.E. PhD Thesis, The mechanism of increased oxygenation via bio-photonic therapy. University of Science Arts and Technology, Montserrat. 2015. USAT Publishing (Montserrat). 110 pp.
Koenig, R. J.; Cerami, A. (1980). "Hemoglobin A1c and diabetes mellitus". Annual Review of Medicine. 31: 29–34. doi:10.1146/annurev.me.31.020180.000333. PMID 6994614.
Einstein, G P, and Tulp, O L. Integrated Sigma Dynamics Quantum Energy Therapy Presented by Mathematical Function and Matrices in Immunologic Stimulation. Proceedings The FASEB Journal, 31(S1). A9324LB., 2017.
Tyuma, Itiro. "The Bohr effect and the Haldane effect in human hemoglobin." The Japanese journal of physiology 34.2 (1984): 205-216.
Tulp, O.L. and Einstein, G P. Efficacy of a Biophotonics Adjunct in viral and microbial infections. J Contemp Med Educ 32(12): 1-14. 2023.
Tulp, OL, Rizvi, SAA, and Einstein GP. Effects of Biophotonic treatment on Hemoglobin A1c and Blood Oxygen Saturation, submitted, ES J Clin Trials. in press, Dec 2023
Gong, L, Zou, Z, Liu, L, Guo, S and Xing, D. Photobiomodulation therapy ameliorates hyperglycemia and insulin resistance by activating cytochrome c oxidase-mediated protein kinase B in muscle. Aging (Albany NY). 2021 Mar 26;13(7):10015-10033. doi: 10.18632/aging.202760. Epub 2021 Mar 26.
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