Flexible and Wearable Volatile Organic Compounds (VOCs) Sensing: Development and Future Perspectives

Authors

  • Houcheng Ren Quantum (Beijing) medical devices co.,ltd, Beijing 100076, PR China

DOI:

https://doi.org/10.14738/aivp.121.16358

Keywords:

Wearable sensor, flexible electronic, gas sensor, volatile organic compounds (VOCs), personalized health

Abstract

Wearable gas sensors based on flexible design can be coupled to the vicinity of biological or environmental interfaces for detecting of volatile organic compounds (VOCs), with greatly simplified sample collection, storage, and analysis process. The flexible devices expand the detection form of sensors and provide continuous and real-time insights for gas detections. Based on wearable exhalation detection system, such as smart facemasks, in-situ and dynamic detection of various VOCs during diet and exercise regulation has been achieved. Thus, the wearable detection provides a unique perspective for biological metabolic activities and important technical support for personalized health detection and disease diagnosis such as pathogens from aerosol. This article introduces the development and application of the flexible wearable in-situ gas sensing technology and provides a detail outlook of the future perspectives in this field.

References

He, C., et al., Recent advances in the catalytic oxidation of volatile organic compounds: A review based on pollutant sorts and sources. Chemical Reviews, 2019. 119(7): p. 4471-4568.

Khatib, M., and Haick, H., Sensors for volatile organic compounds. ACS Nano, 2022. 16(5): p. 7080-7115.

Su, Y., et al., Self-powered respiration monitoring enabled by a triboelectric nanogenerator. Advanced Materials, 2021. 33(35): p. e2101262.

Guntne,r A. T., et al., Breath sensors for health monitoring. ACS Sensor, 2019. 4(2): p. 268-280.

Yang. T., and Duncan. T. V., Challenges and potential solutions for nanosensors intended for use with foods. Nature Nanotechnology, 2021. 16(3): p. 251-265.

Bag. A., and Lee, N-E., Recent advancements in development of wearable gas sensors. Advanced Materials Technologies, 2021. 6(3): p. 2000883.

Bag. A., and Lee. N-E., Gas sensing with heterostructures based on two-dimensional nanostructured materials: a review. Journal of Materials Chemistry C, 2019. 7(43): p. 13367-13383.

Kim, J., et al., Wearable biosensors for healthcare monitoring. Nature Biotechnology, 2019. 37(4): p. 389-

Sempionatto. J. R., et al., Wearable chemical sensors for biomarker discovery in the omics era. Nature Reviews Chemistry, 2022. 6(12): p. 899-915.

Kim, K. H., et al., A review of breath analysis for diagnosis of human health. Trac-trends In Analytical Chemistry, 2012. 33: p. 1-8.

Arnold, C., Diagnostics to take your breath away. Nature Biotechnology, 2022. 40(7): p. 990-993.

Miekisch, W., et al., Diagnostic potential of breath analysis—focus on volatile organic compounds. Clinica Chimica Acta, 2004. 347(1): p. 25-39.

Peng, G., et al., Diagnosing lung cancer in exhaled breath using gold nanoparticles. Nature Nanotechnology, 2009. 4(10): p. 669-673.

Phillips. M., et al., Volatile organic compounds in breath as markers of lung cancer: a cross-sectional study. The Lancet, 1999. 353(9168): p. 1930-1933.

Costello, B. D., et al., A review of the volatiles from the healthy human body. Journal of Breath Research, 2014. 8(1): p. 014001. Ren, H. (2024). Flexible and Wearable Volatile Organic Compounds (VOCs) Sensing: Development and Future Perspectives. European Journal of

Guder, F., et al., Paper-based electrical respiration sensor. Angewandte Chemie International Edition, 2016.

Le, Maout, P., et al., Polyaniline nanocomposites-based sensor array for breath ammonia analysis. Portable enose approach to non-invasive diagnosis of chronic kidney disease. Sensors and Actuators B: Chemical, 2018, 274: p. 616-626.

Craig, R. G., and Hunter, J, M., Recent developments in the perioperative management of adult patients with chronic kidney disease. British Journal of Anaesthesia, 2008. 101(3): p. 296-310.

Jones, A. W., Ethanol metabolism in patients with liver cirrhosis. Journal of Clinical Forensic Medicine, 2000.

Liao, Y. S., et al., Assessment of liver cirrhosis for patients with Child's A classification before hepatectomy using dynamic contrast-enhanced MRI. Clinical Radiology, 2019. 74(5): p. 407.e11-17.

Enko, D., and Kriegshäuser, G., Functional 13C-urea and glucose hydrogen/methane breath tests reveal significant association of small intestinal bacterial overgrowth in individuals with active Helicobacter pylori infection. Clinical Biochemistry, 2017. 50(1): p. 46-49.

Gisbert, J. P., and Pajares, J, M., Review article: 13C-urea breath test in the diagnosis of Helicobacter pylori infection – a critical review. Alimentary Pharmacology and Therapeutics, 2004. 20(10): p. 1001-1017.

Fitzpatrick, A. M., et al., Levels of nitric oxide oxidation products are increased in the epithelial lining fluid of children with persistent asthma. Journal of Allergy and Clinical Immunology, 2009. 124(5): p. 990-996.

Engstler, A. J., et al., Insulin resistance alters hepatic ethanol metabolism: studies in mice and children with non-alcoholic fatty liver disease. Gut, 2016. 65(9): p. 1564.

Puchalska, P., and Crawford, P. A., Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics. Cell Metabolism, 2017. 25(2): p. 262-284.

Güntner, A. T., et al., Noninvasive body fat burn monitoring from exhaled acetone with Si-doped WO3-sensing nanoparticles. Analytical Chemistry, 2017. 89(19): p. 10578-10584.

Kharitonov, S. A., et al., Increased nitric oxide in exhaled air of asthmatic patients. The Lancet, 1994.

Paredi, P., et al., Exhaled ethane is elevated in cystic fibrosis and correlates with carbon monoxide levels and airway obstruction. American Journal of Respiratory and Critical Care Medicine, 2000. 161(4): p. 1247-

Choi, S., et al., Recent advances in flexible and stretchable bio-electronic devices integrated with nanomaterials. Advanced Materials, 2016. 28(22): p. 4203-4218.

Kim, D. H., et al., Flexible and stretchable electronics for biointegrated devices. Annual Review Of Biomedical Engineering, 2012. 14: p. 113-128.

Khan, Y., et al., Monitoring of vital signs with flexible and wearable medical devices. Advanced Materials, 2016. 28: p. 4373-4395.

Amay, J., et al., Non-invasive wearable electrochemical sensors: a review. Trends in Biotechnology, 2014.

Kim, D-H., et al., Epidermal electronics. Science, 2011. 333(6044): p. 838-43.

Gao, W., et al., Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis. Nature, 2016, 529(7587): p. 509-514.

Ates, H. C., and Dincer, C., Wearable breath analysis. Nature Reviews Bioengineering, 2023. 1(2): p. 80-82.

Kalantar-Zadeh, K., et al., A human pilot trial of ingestible electronic capsules capable of sensing different gases in the gut. Nature Electronics, 2018. 1(1): p. 79-87.

Maier, D., et al., Toward continuous monitoring of breath biochemistry: A paper-based wearable sensor for real-time hydrogen peroxide measurement in simulated breath. ACS Sensors. 2019, 4(11): p. 2945-2951.

Wang, L., et al., A flexible, ultra-sensitive chemical sensor with 3D biomimetic templating for diabetes-related acetone detection. Journal of Materials Chemistry B, 2017. 5: p. 4019-4024.

Li, L., et al., Flexible planar concentric circular micro-supercapacitor arrays for wearable gas sensing application. Nano Energy, 2017. 41: p. 261-268.

Xu, H., et al., Multifunctional wearable sensing devices based on functionalized graphene films for simultaneous monitoring of physiological signals and VOC biomarkers. ACS Applied Materials & Interfaces, 2018. 10: p. 11785-11793.

Escobedo, P., Fet al., Smart facemask for wireless CO (2) monitoring. Nature Communications, 2022. 13: p.

Xue, Q., et al. An intelligent face mask integrated with high density conductive nanowire array for directly exhaled coronavirus aerosols screening. Biosensors and Bioelectronics, 2021. 186: 113286.

Nguyen, P. Q., et al., Wearable materials with embedded synthetic biology sensors for biomolecule detection. Nature Biotechnology, 2021. 39(11): p. 1366-1374.

Wang, B., et al., Wearable bioelectronic masks for wireless detection of respiratory infectious diseases by gaseous media. Matter, 2022. 5(12): p. 4347-4362.

Shan, B., et al., Multiplexed nanomaterial-based sensor array for detection of COVID-19 in exhaled breath. ACS Nano, 2020. 14(9): p. 12125-12132.

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Published

2024-02-01

How to Cite

Ren, H. (2024). Flexible and Wearable Volatile Organic Compounds (VOCs) Sensing: Development and Future Perspectives. European Journal of Applied Sciences, 12(1), 244–254. https://doi.org/10.14738/aivp.121.16358