Synthesis and Characterization of Stimuli-Responsive Poly (Maleic Acid-Co-Malic Acid-Co-Propane-1,2-Diol-Co-Adipic Acid)

Authors

  • Md. Abdul Matin Department of Materials Science and Engineering, University of Rajshahi, Rajshahi-6205, Bangladesh
  • Monishita Nuzhat Chowdhury Department of Materials Science and Engineering, University of Rajshahi, Rajshahi-6205, Bangladesh
  • Anjuman Ara Khatun Department of Materials Science and Engineering, University of Rajshahi, Rajshahi-6205, Bangladesh
  • Jahanara Nasrin Department of Materials Science and Engineering, University of Rajshahi, Rajshahi-6205, Bangladesh
  • Abu Mahmud Department of Materials Science and Engineering, University of Rajshahi, Rajshahi-6205, Bangladesh

DOI:

https://doi.org/10.14738/aivp.112.14193

Keywords:

Polymer, Stimuli-Responsive, Co-Polyester, Biodegradable, Enteric Coating

Abstract

Poly (Maleic acid-co-Malic acid-co-Propane-1,2-diol-co-Adipic acid) was synthesized using the Dean-Stark apparatus. Stoichometric proportions of maleic acid, malic acid, adipic acid and propane-1, 2-diol were taken in a round bottom flask along with a trace amount of anhydrous ferric chloride which worked as catalyst and o-xylene  used as reaction medium. The total system was heated at temp. 135-1400C for about 5 hours. Molecular weight, FTIR-spectra, thermo gravimetric and elemental analysis, solubility tests in common organic solvents, melting point and degradation tests were used for the characterization of the synthesized co-polyester. At room temperature (300C) the hydrolytic degradation study of the co-polyester in solutions of various pH values (pH=1.15-4.40) showed that, there has no degradation of the co-polyester, but it gradually degraded in solutions of pH values 6.50-8.99. This showed its stimuli-responsive characteristics. The co-polyester almost 70% degraded in normal soil within 30 days indicating its biodegradable nature. If satisfactory toxicity result of the synthesized co-polyester is observed, it might be usable as an enteric coating material.

References

Asano, M., Yoshida, M., Maetsu, I.,Imai,K.,Tooru,M.,Yuasa,H.,Yamanaka,H.&Suzuki,K.(1985).Macromol.Chem.Rapid Commun.6, 509.

Bakr, M.A., Hasan, K.,Islam,M.A.,Khatun,S.,Mannan,M.A.andAra,K.S.(2006) .J.Polym.Mater.23 ,217-222.

Bakr, M.A., Islam, M.A., Karim, M.A. and Ahmed,M.. (2000) .J.Polym.Mater.17 ,467-472.

Bawa,P., Pillay1,V., Choonara ,Yahya E. and Toit, Lisa C du. (2009) “Stimuli-responsive polymers and their applications in drug delivery”1-2

Bertrand N, Leroux JC.; Leroux (2011). "The journey of a drug carrier in the body: an anatomo-physiological perspective". Journal of Controlled Release. 161 (2): 152–63.

Devi,K.S. and Vasudevan,P.(1985).JMS.Rev.Macromol.Chem.Phys.C 25(3),315.

Galaev, Igor; Mattiasson, Bo, eds. (2010). Smart Polymers: Applications in Biotechnology and Biomedicine. CRC Press. ISBN 1439858160. Retrieved 2013-03-20.

Gliding,D.K. & Reed,A.M.(1979).Polymer 20, 1459.

Grsham,N.B.(1978).J.British Polym. 10,260.

Heller,J.(1980). Biomaterials 1, 50.

Muller, R and Keck, C .(2004)"Challenges and solutions for the delivery of biotech drugs – a review of drug nanocrystal technology and lipid nanoparticles". Journal of Biotechnology. 113 (1–3):151–170.

Rosenberg, H.B., Chang,J.,Wnek,G.E.,Linhardt,R.J.&Langer,R.(1993).J.Biomaterials 4, 131.

Saltzman,W.Mark and Torchilin, Vladimir P. (2008). "Drug delivery systems". AccessScience. McGraw-Hill Companies.

Siniaguine,O .& Kachiguina,E.(2015) "Self-adaptive and optionally also otherwise adaptable wound dressing",US patent US9050211 B2.

Wolcott, R.; Fischenich, V. (2014). "Ultimate Standardization of First-Line Wound Dressings to a Single Type". Today's Wound Clinic. 8 (3).

Downloads

Published

2023-04-13

How to Cite

Matin, M. A., Chowdhury, M. N., Khatun, A. A., Nasrin, J., & Mahmud, A. (2023). Synthesis and Characterization of Stimuli-Responsive Poly (Maleic Acid-Co-Malic Acid-Co-Propane-1,2-Diol-Co-Adipic Acid). European Journal of Applied Sciences, 11(2), 482–490. https://doi.org/10.14738/aivp.112.14193

Issue

Vol. 11 No. 2 (2023): European Journal of Applied Sciences

Section

Articles

License

Copyright (c) 2023 Md. Abdul Matin, Monishita Nuzhat Chowdhury, Anjuman Ara Khatun, Jahanara Nasrin, Abu Mahmud

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.