{"id":8307,"date":"2022-04-09T16:24:39","date_gmt":"2022-04-09T11:24:39","guid":{"rendered":"https:\/\/scholarpublishing.org\/sse\/?p=8307"},"modified":"2022-09-03T13:15:19","modified_gmt":"2022-09-03T08:15:19","slug":"eb264","status":"publish","type":"post","link":"https:\/\/scholarpublishing.org\/sse\/eb264\/","title":{"rendered":"Identification of Novel Human Cancer-Specific Antigens"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"8307\" class=\"elementor elementor-8307\">\r\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2ca4ceb1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2ca4ceb1\" data-element_type=\"section\" data-e-type=\"section\">\r\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\r\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-468d5bd\" data-id=\"468d5bd\" data-element_type=\"column\" data-e-type=\"column\">\r\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\r\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-71232cd1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"71232cd1\" data-element_type=\"section\" data-e-type=\"section\">\r\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\r\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-c38f118\" data-id=\"c38f118\" data-element_type=\"column\" data-e-type=\"column\">\r\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\r\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3001a238 custom-sub-heading elementor-widget elementor-widget-heading\" data-id=\"3001a238\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\r\n\t\t\t\t<div class=\"elementor-widget-container\">\r\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Identification of Novel Human Cancer-Specific Antigens<\/h2>\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t<\/section>\r\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-7ef9de76 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7ef9de76\" data-element_type=\"section\" data-e-type=\"section\">\r\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\r\n\t\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-inner-column elementor-element elementor-element-3240fec2\" data-id=\"3240fec2\" data-element_type=\"column\" data-e-type=\"column\">\r\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\r\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-55f9654 elementor-widget elementor-widget-heading\" data-id=\"55f9654\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\r\n\t\t\t\t<div class=\"elementor-widget-container\">\r\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">Rasha Ali Hussain Al-Khafaji<\/h6>\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t<div class=\"elementor-element elementor-element-5862641a elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"5862641a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-list.default\">\r\n\t\t\t\t<div class=\"elementor-widget-container\">\r\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\r\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\r\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Radiology Department, Regional Hospital Midt, Viborg, Denmark<\/span>\r\n\t\t\t\t\t\t\t\t\t<\/li>\r\n\t\t\t\t\t\t<\/ul>\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t<div class=\"elementor-element elementor-element-707bca8a elementor-icon-list--layout-inline elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"707bca8a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-list.default\">\r\n\t\t\t\t<div class=\"elementor-widget-container\">\r\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items elementor-inline-items\">\r\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item elementor-inline-item\">\r\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\"><strong>DOI:<\/strong><\/span>\r\n\t\t\t\t\t\t\t\t\t<\/li>\r\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item elementor-inline-item\">\r\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/doi.org\/10.14738\/eb.264.2022\" target=\"_blank\">\r\n\r\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">https:\/\/doi.org\/10.14738\/eb.264.2022<\/span>\r\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\r\n\t\t\t\t\t\t\t\t\t<\/li>\r\n\t\t\t\t\t\t<\/ul>\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t<div class=\"elementor-element elementor-element-45106749 elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"45106749\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-list.default\">\r\n\t\t\t\t<div class=\"elementor-widget-container\">\r\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\r\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\r\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\"><strong>Keywords:<\/strong><\/span>\r\n\t\t\t\t\t\t\t\t\t<\/li>\r\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\r\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Cancer Testis Antigens, Cancer Vaccination, Immunotherapy, Meiosis, Infertility<\/span>\r\n\t\t\t\t\t\t\t\t\t<\/li>\r\n\t\t\t\t\t\t<\/ul>\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t<div class=\"elementor-element elementor-element-7eba5e22 custom-text-justify elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"7eba5e22\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-list.default\">\r\n\t\t\t\t<div class=\"elementor-widget-container\">\r\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\r\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\r\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\"><strong>Abstract:<\/strong><\/span>\r\n\t\t\t\t\t\t\t\t\t<\/li>\r\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\r\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Cancer imposes continuous challenges on global health, and the trend of its incidence will make it the leading cause of mortality in the twenty-first century (Robert, Vries &amp; Hans 2010). Therefore, identifying novel-cancer antigens that can be used as biomarkers and targets for therapeutics has been a priority to minimize cancer morbidity and mortality rates (Grizzi et al. 2007).<\/span>\r\n\t\t\t\t\t\t\t\t\t<\/li>\r\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\r\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Cancer testis antigens genes\u2019 (CTAs) characteristics of immune privilege restricted expression, aberrant expression in unrelated histological malignancies, and immunogenicity have made them a valuable family to be exploited for cancer research and clinical therapeutics (Joseph-Pietras et al. 2010; Shigematsu et al. 2010).<\/span>\r\n\t\t\t\t\t\t\t\t\t<\/li>\r\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\r\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Germ cell characteristics, such as global hypomethylation, telomerase activity, CTA expression, and the presence of several meiosis stage-specific proteins, are common features in cancer. Therefore, many sperm-specific proteins may contain novel-cancer testis antigens (Silina et al. 2011; Gjerstorff et al. 2010; Gjerstorff, Burns &amp; Ditzel 2010).<\/span>\r\n\t\t\t\t\t\t\t\t\t<\/li>\r\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\r\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Through whole-genome profiling of male germline expression in mice, rats, and humans, several loci have shown a conserved sequence in meiotic and post-meiotic profiles. Though hybridization of the mice testis mRNA to human testis tissue, a microarray study revealed a positive signal of 81% from the clones (Sha et al. 2002). These are likely essential for sexual production, and several have detectable expression profiles in cancers. Therefore, as previously states, gametogenesis and carcinogenesis may share a similar molecular mechanism (Chalmel, Lardenois &amp; Primig 2007)<\/span>\r\n\t\t\t\t\t\t\t\t\t<\/li>\r\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\r\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Given this, our research group has designed an in silico pipeline analysis that has identified a high number of candidate cancer-specific markers that could be promising in the oncology field. Using this approach, C4orf35, C13orf28, C18orf54, C20orf195, C22orf33, PPP4R4, SPACA1, and TMCO2 have been filtered.<\/span>\r\n\t\t\t\t\t\t\t\t\t<\/li>\r\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\r\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">According to Hofmanna et al. (2008), gene expression in a CTA is restricted to the testis and cancer; furthermore, Mobasheri et al. (2007) found that a good CTA candidate should only be expressed in testis and cancer cell lines. Therefore, we analysed an expression profile of these genes in a panel of normal tissue samples by semi-quantitative RT-PCR using tailored primers for each candidate; b-actin was used as an unchanged and fixed endogenous gene reference. Only upon testis restricted gene expression will a gene be validated for screening in our designed panel of cancer samples<\/span>\r\n\t\t\t\t\t\t\t\t\t<\/li>\r\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\r\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Our research is small in size, of an exploratory nature, and was not designed to quantify expression; rather, it is designed as a preliminary validation of several genes that were categorised for meiosis and cancer expression. However, our results should not be over-looked. In the given set of the XV. experiment, the author has managed to identify C22orf33 and SPACA1 as potential candidates. In spite of having additional expression in the thymus, C18orf54 is also a good candidate. As will be demonstrated, all remaining genes, with the exception of TMCO2, could have potential use in the field of oncology field through the cautious interpretation of currently available data. Our study is not large enough to answer many questions related to these genes, provide further information on a putative function of these expressions, or validate the available data. As such, further experiments on a broader scale are warranted.<\/span>\r\n\t\t\t\t\t\t\t\t\t<\/li>\r\n\t\t\t\t\t\t<\/ul>\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t<div class=\"elementor-element elementor-element-6716f9a4 elementor-widget elementor-widget-text-editor\" data-id=\"6716f9a4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\r\n\t\t\t\t<div class=\"elementor-widget-container\">\r\n\t\t\t\t\t\t\t\t\t<!-- References Button -->\n<div class=\"py-3 text-center\"><button class=\"btn btn-lg btn-primary\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#collapseExample\" aria-expanded=\"false\" aria-controls=\"collapseExample\">\nView References\n<\/button><\/div>\n\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t<div class=\"elementor-element elementor-element-7a199f8a elementor-widget elementor-widget-text-editor\" data-id=\"7a199f8a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\r\n\t\t\t\t<div class=\"elementor-widget-container\">\r\n\t\t\t\t\t\t\t\t\t<div id=\"collapseExample\" class=\"collapse mt-3\">\n<ol>\n \t<li>Adamo, A., Montemauri, P., Silva, N., Ward, J.D., Boulton, S.J. &amp; 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elementor-element-populated\">\r\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-590161df img-thumbnail elementor-widget elementor-widget-image\" data-id=\"590161df\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\r\n\t\t\t\t<div class=\"elementor-widget-container\">\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"237\" height=\"300\" src=\"https:\/\/scholarpublishing.org\/sse\/wp-content\/uploads\/2022\/04\/eb264-237x300.png\" class=\"attachment-medium size-medium wp-image-8308\" alt=\"Identification of Novel Human Cancer-Specific Antigens\" srcset=\"https:\/\/scholarpublishing.org\/sse\/wp-content\/uploads\/2022\/04\/eb264-237x300.png 237w, https:\/\/scholarpublishing.org\/sse\/wp-content\/uploads\/2022\/04\/eb264.png 409w\" sizes=\"(max-width: 237px) 100vw, 237px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t<div class=\"elementor-element elementor-element-189cbdfb dropdown-divider elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"189cbdfb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\r\n\t\t\t\t<div class=\"elementor-widget-container\">\r\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\r\n\t\t\t<span class=\"elementor-divider-separator\">\r\n\t\t\t\t\t\t<\/span>\r\n\t\t<\/div>\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t<div class=\"elementor-element elementor-element-45dc6cf0 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"45dc6cf0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\r\n\t\t\t\t<div class=\"elementor-widget-container\">\r\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\r\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-lg\" 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Ali Hussain Al-Khafaji<\/span>\r\n\t\t\t\t\t\t\t\t\t<\/li>\r\n\t\t\t\t\t\t<\/ul>\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t<div class=\"elementor-element elementor-element-6806e305 custom-sub-heading elementor-widget elementor-widget-heading\" data-id=\"6806e305\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\r\n\t\t\t\t<div class=\"elementor-widget-container\">\r\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">License<\/h5>\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t<div class=\"elementor-element elementor-element-5a0b6856 elementor-widget elementor-widget-text-editor\" data-id=\"5a0b6856\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\r\n\t\t\t\t<div class=\"elementor-widget-container\">\r\n\t\t\t\t\t\t\t\t\t<p>This work is licensed under a\u00a0<a href=\"https:\/\/creativecommons.org\/licenses\/by\/4.0\/\" rel=\"license\">Creative Commons Attribution 4.0 International License<\/a>.<\/p>\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t<div class=\"elementor-element elementor-element-4a258fa5 dropdown-divider elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"4a258fa5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\r\n\t\t\t\t<div class=\"elementor-widget-container\">\r\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\r\n\t\t\t<span class=\"elementor-divider-separator\">\r\n\t\t\t\t\t\t<\/span>\r\n\t\t<\/div>\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t<\/section>\r\n\t\t\t\t\t<\/div>\r\n\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t<\/section>\r\n\t\t\t\t<\/div>\r\n\t\t","protected":false},"excerpt":{"rendered":"<p>Cancer imposes continuous challenges on global health, and the trend of its incidence will make it the leading cause of mortality in the twenty-first century (Robert, Vries &#038; Hans 2010). Therefore, identifying novel-cancer antigens that can be used as biomarkers and targets for therapeutics has been a priority to minimize cancer morbidity and mortality rates (Grizzi et al. 2007)<\/p>\n","protected":false},"author":2,"featured_media":8308,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"disabled","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[2,62],"tags":[395,396,397,398,399],"class_list":["post-8307","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ebooks","category-medicine","tag-cancer-testis-antigens","tag-cancer-vaccination","tag-immunotherapy","tag-infertility","tag-meiosis"],"_links":{"self":[{"href":"https:\/\/scholarpublishing.org\/sse\/wp-json\/wp\/v2\/posts\/8307","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/scholarpublishing.org\/sse\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/scholarpublishing.org\/sse\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/scholarpublishing.org\/sse\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/scholarpublishing.org\/sse\/wp-json\/wp\/v2\/comments?post=8307"}],"version-history":[{"count":37,"href":"https:\/\/scholarpublishing.org\/sse\/wp-json\/wp\/v2\/posts\/8307\/revisions"}],"predecessor-version":[{"id":8784,"href":"https:\/\/scholarpublishing.org\/sse\/wp-json\/wp\/v2\/posts\/8307\/revisions\/8784"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/scholarpublishing.org\/sse\/wp-json\/wp\/v2\/media\/8308"}],"wp:attachment":[{"href":"https:\/\/scholarpublishing.org\/sse\/wp-json\/wp\/v2\/media?parent=8307"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/scholarpublishing.org\/sse\/wp-json\/wp\/v2\/categories?post=8307"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/scholarpublishing.org\/sse\/wp-json\/wp\/v2\/tags?post=8307"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}