British Journal of Healthcare and Medical Research

Modification of Imperfect Cancer Drugs to Become Perfect Cancer Drugs to Save Cancer Patients

Ming C. Liau — 2024-03-08

The objective of this study is to develop perfect cancer drugs to save cancer patients. A specific aim is to save King Charles who was recently diagnosed to have cancer. Perfect cancer drugs are the drugs capable of inactivating abnormal methylation enzymes (MEs) to take out both cancer stem cells (CSCs) and cancer cells (CCs) by inducing these cells to undergo terminal differentiation, and to restore chemo-surveillance to save cancer patients. Imperfect cancer drugs are cytotoxic agents capable of killing CCs but cannot affect CSCs, which also contribute to the destruction of chemo-surveillance to cause fatality of advanced cancer patients. The ineffectiveness against CSCs and the destruction of chemo-surveillance are responsible for the failure of imperfect cancer drugs to cure cancer. Cell differentiation agent-2 (CDA-2) was a persuasive perfect cancer drug approved by the Chinese FDA, the rest of the world do not have a really perfect cancer drug. CDA-2 was a preparation of wound healing metabolites purified from urine, which could serve as a model for the development of CDA formulations as perfect cancer drugs. Wound healing metabolites active as differentiation inducers (DIs) and differentiation helper inducers (DHIs) are the active players of chemo-surveillance created by the nature as allosteric regulators of abnormal methylation enzymes (MEs), which are the most critical issue of cancer. The elimination of abnormal MEs is very effective to cure cancer. Wound healing is a simple matter that comes naturally, because the nature creates chemo-surveillance to ensure perfection of wound healing. Cancer is the consequence of wound unhealing due to the collapse of chemo-surveillance. Cancer therapy can also be a simple matter, if the therapy follows wound healing process. PSCs and CSCs are cells with abnormal MEs, which are protected by drug resistance and anti-apoptosis mechanisms. PSCs are the cells involved in wound healing. Efficient induction of terminal differentiation of PSCs is very critical to the success of wound healing. Natural DIs and DHIs are the partners of PSCs and CSCs in wound healing, which can easily access to PSCs and CSCs. If wound is not healed, PSCs are forced to evolve into CSCs and then to progress to faster growing CCs. CCs display a high level of degradative enzymes to generate substrates for the syntheses of macromolecules to support their faster growth. Natural DIs and DHIs may be rapidly degraded in CCs. A different set of unnatural DIs and DHIs may be necessary to achieve the induction of terminal differentiation of CCs. Thus, two sets of CDA formulations, one CDA-CSC with natural DIs and DHIs, and another CDA-CC with non-natural DIs and DHIs to accomplish effective therapy of cancer. We have carried out extensive studies on natural DIs and DHIs presented in the urine, and unnatural DIs and DHIs as telomerase inhibitors, signal transduction inhibitors, targeted therapeutic agents and growth inhibitors for the formulations of CDA-CSCs and CDA-CCs.

Outcomes of Religion and Faith on Mental Health among the Seventh-day Adventists in Africa

Daniel Ganu — 2024-03-08

Numerous studies have linked and synchronized religious experiences with positive mental health. Despite the prevalence of mental health concerns, there is still a stigma attached to mental illness in many of the Seventh-day Adventist (SDA) churches in Africa. The predominant culture of silence, along with mistaken expectations and misguided attitudes, often causes suffering believers to feel ashamed, blamed, and alone in their experience of mental illness. This study aimed to assess the SDA church members' mental health in Africa. The paper summarized some of the most important factors that were found to correlate with the religious and mental health experiences of the SDA church in the continent of Africa. The study utilized a cross-sectional design and quantitative data collection method. The 213-item questionnaire contained closed and open-ended items and was administered by trained research assistants. The study revealed that married people in the church tend to have more positive mental health than those who are single, separated, divorced, or widowed, and older people tend to have more positive mental health than younger people (p<.05). Moreso, the older age group demonstrated more positive mental health compared with the younger age group (p < 0.01) in the church. Furthermore, 80.6% and 87.3% of the participants have never had any form of depression or suicidal thoughts, respectively. The demonstration of positive general mental health status by the church members in the continent of Africa has positive implications for the health principles taught by the church.

Surgery for Complications of Acute Pancreatitis-A Case Series

Sardar Mohammad Rezaul Islam — 2024-03-13

Sixteen patients operated for complication of acute pancreatitis for a period of 5 years. We drained 4 infected pancreatic ascites, 3 hemorrhagic pancreatitis. We performed 6 Roux Y cysto-jejunostomy for pseudocystof the pancreas. We managed one patient with ruptured Walled Off Necrosis (WON) by 2 staged procedures. Initially laparotomy, debridement of the infected necrosis and external drainage was done. After 6 weeks permanent internal drainage was done by Roux-Y Cysto-jejunostomy for persistent pancreatic fistula. 2 patients with walled off necrosis had debridement only. All patients recovered successfully.

Biofield Energy – History and Applications of Kinesiology Muscle Testing

Seema Bhattessa — 2024-03-13

In the 1960s, a chiropractor in the United States adapted manual muscle testing (MMT), a procedure in which muscle strength and nerve function are subjectively assessed, as a method for evaluating and correcting structural imbalances, naming the practice Applied Kinesiology (AK). The practice of AK was eventually developed into a multifaceted system using MMT as a means through which information about the function of organs and systems can be derived. AK cites the neurological principle of sensory and motor integration known as the central integrated state, i.e., the summative effects of all activating and inhibiting influences on motor output, as the basis for the ability of MMT to reflect organ function beyond that of muscle or nerve function alone. Over the ensuing decades, interest in this evaluative technique has expanded beyond the chiropractic profession, and it has been adapted for use in a number of both conventional and complementary healthcare disciplines. This review article briefly explores the history and applications of MMT as an evaluative tool.

Functional Constipation in Children: Pathophysiology, Diagnosis, and Management

Rajeev Gupta — 2024-03-13

Functional constipation (FC) is a common paediatric issue, affecting 3% of children worldwide [1]. The condition can have a significant impact on the quality of life for both children and their families. This review focuses on the current understanding of the pathophysiology, diagnosis, and management of FC in children, with an emphasis on recent advances and guidelines. Recognising and addressing constipation in children is crucial for their overall health and well-being. Due to the unique developmental, behavioural, and physiological differences between children and adults, a tailored and comprehensive approach is essential for effective management in paediatric populations.

Why We Should Strive For A Toxin-Free Mouth

Manfred Doepp — 2024-03-19

In addition to other factors, intoxication from foreign substances that the body does not need, but which burden it, are harmful to the organism. They lead to organ weaknesses and reduce life expectancy. Nowadays, the oral cavity has become an important source of toxins. This concerns light and heavy metals on the one hand and cadaveric toxins from dead tissue on the other. In addition, foci in the mouth have the ability to disrupt and block the regulation of organ functions. Tooth roots and the adjacent jawbones are more important than the teeth themselves. Non-infectious chronic jawbone osteitis, for example, can be a risk factor for cancer. These facts should prompt us all to strive for a toxin-free mouth.

Factors Associated with Hemoglobinemia After 12 Months of Lucky Iron Fich (LIF) Use in Women of Reproductive Age (FAR, 15-49 years) in the Tambacounda Health District in 2020 (Senegal)

Fatoumata Binetou Diongue — 2024-03-19

Introduction: Senegal is one of the countries where food insecurity and malnutrition are major development challenges, the aim was to determine the factors influencing the increase in hemoglobinemia after Lucky Iron Fich (LIF) use. Methods: The methodological approach was based on a longitudinal, descriptive and analytical study between the results of the baseline (2019) and 12-month (2020) surveys. The population consisted of women aged 15 to 49 years who were followed up since 2019. Multiple linear regression modeling was performed with an alpha risk of 5%. Results: Of the 428 anemic women followed up, 34.0% were no longer anemic. The mean age was 28.4 years (+/-8.9). Almost half of the households (49.8%) lived in poverty. The mean hemoglobinemia was 10.1 (+/-2.3) g/dl, with values of 10.5 (+/-1.6 g/dl); 9.7 (+/-2.2 g/dl); 10.3 (+/-2.6 g/dl); and 9.8 (+/-2.5 g/dl) for the subgroups of LIF alone, LIF and livestock, LIF and farming, and no LIF at baseline. These means were statistically different from baseline in the response groups, except for the control group. The difference in hemoglobinemia was increased by 0.60 g/dl (p-value=0.04) with LIF and by 1.72 g/dl (p-value=0.02) with secondary education or higher. Conclusion: Lucky Iron Fish was effective in increasing hemoglobinemia after 12 months of use. It improved hemoglobinemia in FAR in the medium term.

Effects of Biophotonic Treatment on Glycemic, Metabolic, and Hematologic Parameters

Orien L. Tulp — 2024-03-23

The wide-ranging effects of healthful vs. damaging consequences of UV irradiation on key physiologic parameters linked to carbohydrate metabolism are reviewed in this paper. The effects are largely dependent on the wavelengths encountered, the absolute intensity and duration of the exposure, the tissues exposed, and whether the UV effects were delivered via in vivo, as an extracorporeal exposure of intact tissues or in vitro from freshly obtained heparinized aliquots of whole blood. While damaging effects of high UV intensity may include irreversible irradiation damage to molecular components, administration of controlled low dosages and controlled wavelengths of UV irradiation delivered via a conventional biophotonic apparatus can deliver beneficial effects on blood oxygenation, tissue repair, immune responses, glycemic responses, and glycated hemoglobin (HbA1c) concentrations. HbA1c percentage in whole blood is a major diagnostic marker for the effectiveness of diabetes management. In studies with diabetic mouse models, GLUT4, Oral Glucose Tolerance, Insulin response to a glucose challenge, ATP content, and glycogen synthesis in skeletal muscle were found to be significantly improved following photonic treatments. In vivo Studies reviewed demonstrated increases in blood oxygenation and corresponding decreases in HbA1c concentrations following nominal biophotonic treatment. These observations indicate that the application of biophotonic therapy extends beyond its more commonly applied applications for the treatment and control of infectious illnesses and anti-aging therapeutics and may also include important potential beneficial effects in obesity and insulin resistant conditions typical of type 2 diabetes mellitus.

A Suitable Occlusion

Gene McCoy — 2024-03-19

Recently, an article¹ appeared asking, what is the most suitable occlusion for implant rehabilitation? The question is challenging since we have yet to answer that question for ordinary restorative dentistry. Occlusion has the reputation of being the most crucial subject in dentistry, but also the most controversial. After all these years, what seems to be the problem? Exactly, what is a suitable occlusion? A simple answer is evasive because, over the years, the word’s meaning has changed from an adjective describing teeth closure to a noun understanding of the masticatory system itself.² The circumstances that led to this transformation began when dentists were confronted with the damaging lateral forces of bruxism. They focused solely on the management because there was insufficient information regarding bruxism’s etiology to assume a proactive approach. They discovered that by equilibration, bruxism’s destructive lateral forces could be reduced by redirecting them to a more forward position (group function to cuspid rise). Since this process of “creating an occlusal scheme” successfully reduced heavy lateral forces, it became apparent that occlusion in function was just as important, maybe more so, than occlusion in closure, and the term “Functional Occlusion” ³became synonymous with the masticatory system.

“Burnout,” Bioethics, and the Practice of Medicine

Tom Koch — 2024-03-23

Following the recent pandemic a large number of practitioners retired or resigned from clinical service. While Covid-19 was unexceptional in its effect on health services and practitioners—we had seen similar stressors in previous epidemics/pandemics—this was unprecedented. In the past, practitioners were typically tired from caring but in the main affirmed in their vocation of caring. One reason for this change, it is argued, was the commercialized and bureaucratic view of medicine introduced with bioethics by the end of the 1970s. That cange, and its relation to practitioners, is the focus of this brief article.

Virtual and Augmented Reality: Prospects in Radiology Education and Training

Mariana Yordanov — 2024-04-05

Purpose: This article reviews the applications of virtual and augmented reality in medical education and training in the field of radiology. The article studies existing scientific literature on the uses of virtual and augmented reality in radiology education and training and their benefits. Materials and methods: This article use available scientific literature on VR and AR applications in radiology education and training from PubMed, Google Scholar and ScienceDirect. Results: Virtual and augmented reality offer specialized medical and commercial tools for radiology education and training in imaging and interventional radiology. They include VR games, life-sized simulation environments, computerized sensor tables, head-mounted devices and others. Tests and studies of VR and AR technologies for students and residents show promising results for educational value and improved educational outcomes. Nevertheless, there are many challenges in the adoption of virtual and augmented reality for medical education and training. Conclusions: The prospects of virtual and augmented reality in radiology education and training are promising but more scientific studies are needed to ensure their benefits.

Attitudes of Public Hospital Nurses in Greece Toward Cultural Diversity and Their Association with Empathy

Georgia Gazi — 2024-04-05

This study aimed to investigate the attitudes of public hospital nurses in Greece toward cultural diversity and explore the relationship between these attitudes and empathy. A 4-month cross-sectional quantitative study was conducted from October 2022 to January 2023. The questionnaires were distributed using the Google Forms platform, and the sample comprised 179 nurses (n=179) employed in public hospitals. The questionnaire encompassed demographic and work-related inquiries, along with sections on cross-cultural health education and the Clinical Culture Competency Questionnaire (CCCQ) and Toronto Empathy Questionnaire (TEQ). Data analysis was carried out using SPSS software, version 28. The results indicated that nurses exhibit a moderate to fairly high level of positive attitudes toward ethnic minority patients, alongside a low level of empathy. Additionally, a positive weak correlation was observed between cultural skills and empathy (r=.223, p<.001), as well as between management of cultural situations and empathy (r=.162, p<.005). Significant differences in nurses' attitudes toward cultural diversity and empathy were identified based on specific demographic characteristics and their training experiences in intercultural health. In conclusion, this study underscores the importance of nurturing more positive attitudes among nurses toward patients from ethnic minorities. This necessitates a concerted effort to enhance both empathy and training in intercultural health. By fostering these qualities, healthcare professionals can better address the diverse needs of patients, thereby promoting more inclusive and effective healthcare delivery.

Use of Electronic Cigarette or Vape Associated with Massive Hemoptysis: Case Report

María Gabriela Pesqueira Valerio — 2024-04-05

Vaping involves the use of a device to deliver aerosolized substances to the lungs, its popularity continues to increase; However, because it is a new drug delivery system, there is little evidence about its safety and long-term use. We present the case of a 37-year-old man, with a history of vaping with cannabis oil and tetrahydrocannabinol (THC), who presented with a hemoptoic cough. A diagnosis of lung injury associated with electronic cigarettes or vaping (EVALI) is made, visible by chest CT, as well as by angiotomography of the pulmonary arteries. The patient developed massive hemoptysis and hypovolemic shock, which made it necessary to perform a right lower lobectomy. There are reports in the literature associated with this case, however, no one was found that associated it with massive hemoptysis and/or the need to perform lobectomy.

Findings in Tooth Roots and Jaw Bones May Cause Cancer

Manfred Doepp — 2024-04-05

According to all the latest findings, the incidence of cancer is rising in most countries. This applies, for example, to countries with a high rate of vaccination with mRNA vaccines. These are also the countries with a high standard of conservative dentistry. This dentistry does not remove dead tissue, root foci, potentially toxic metals or foci in the jawbone, but aims to achieve a surface that is as esthetic as possible and well suitable for chewing. There is evidence in the literature that non-infectious chronic cases of osteomyelitis of the jaw (NICO, FDOK) in particular pose a risk of serious diseases, including cancer. The author had to experience this several times, one case is described. The corresponding laboratory value "Rantes" should be included in cancer prophylaxis.

The Involvement of Carbon Monoxide in Mitochondrial Activity and Brain Functions

Avraham Mayevsky — 2024-04-05

The central nervous system is the most sensitive tissue to carbon monoxide and usually receive the greatest lasting damage from CO poisoning. In the current set of experiments, the differences between the physiological responses and the toxic effects were studied. The effects of 1000, 2000 and 3000 ppm CO were studied in rats monitored by a unique multiparametric monitoring system providing information on the hemodynamic, metabolic, ionic and electrical activities in an un-anesthetized state. The effect of cortical spreading depression following the exposure to CO was investigated. The results show that exposure to 1000 ppm CO for 40 minutes doesn’t have a deleterious effect on the resting brain but apparently interfere with metabolic activity during brain activation by cortical spreading depression. Exposure to 2000 ppm CO resulted in elevation of cerebral blood flow. The stability of mitochondrial NADH redox level during CO exposure indicated that tissue hypoxia did not develop. The elevation in blood flow was inhibited by L-nitroarginine methyl ester, indicating that nitric oxide was responsible for the CO-induced elevation in blood flow. Exposure to 2000 ppm CO also triggered a significant decrease in pH and rise in extracellular potassium ion, possibly due to ion-pump inhibition. The amplitude of the electrocorticogram wave activity decreased, indicative of a compromise to physiological activity.

Knowledge, Attitude and Practices on Family Planning Among Women Receiving Antenatal Care at University of Nigeria Teaching Hospital Enugu

Stella O Okoye — 2024-04-05

Family planning is the practise of controlling the number of children one has and the intervals between their births, particularly by means of contraceptive or voluntary sterilization. Ability of women to space and limit her pregnancies has a direct impact on her health and well-being as well as on the outcome of each pregnancy. Contrary poor family planning practices has excessive burden on family budget which in many cases leads to poor quality of life in various aspects such as health, education, environment and housing.The aim of this study is to assess the knowledge, attitude and practices of family planning among women receiving antenatal care at University of Nigeria Teaching Hospital Enugu. The study was conducted by using a pre-tested, structured self administered questionnaire for four months between the periods of June to September 2022 in University of Nigeria Teaching Hospital, Ituku Ozalla, Enugu, Nigeria. The level of knowledge, attitude and practise of family planning were elicited from the questionnaire as well as factor affecting it. Most of all the women had knowledge of family planning/contraceptives (98.6%). Their sources of information were majorly through TV/radio (52.2%). Though the attitude of the women to facts of family planning information was poor (40.3%), most women still practiced family planning methods (87.0%). Withdrawal, natural and behavior, injectables and barrier were the most adopted methods. The factors such as desire for children, side effects/ fear of complication and lack of knowledge of modern methods affect usage of family planning. The level of knowledge of family planning among the pregnant women was high (98.6%) and most women practiced family planning methods (87.0%)

A New Approach to Stopping Viral Infections: Intestinal Tract as The Main Important Reservoir of Viruses Hidden in Carriers After Overcoming Infections

Vladimir Zajac — 2024-04-13

Viruses are parasites. However, this basic fact is not accepted by most experts, virologists. This attitude is a disregard for the fact that a virus is a parasite that cannot exist on its own and is completely dependent on its carrier. This is the basic condition of its existence. The host of the parasite is a living cell. Which living cells are carriers of viruses

Utility of Computerized Axial Tomography (CT) Investigation in Two-Week Wait Colorectal Referral Pathway During the COVID-19 Pandemic: A Retrospective Analysis

Akshay Bavikatte — 2024-04-13

Introduction: Colorectal two-week wait pathway investigations have been majorly affected by Covid 19, especially with regard to endoscopy as well as virtual colonoscopy procedures in comparison to computerized tomography (CT) scans. We aimed to analyze the CT findings of patients referred along the week wait pathway at the height of the pandemic. Method: A total of 900 patients were referred via the straight-to-test pathway in 2020, from March to December, at the West Suffolk Hospital NHS Trust. A retrospective analysis of the CT scans of these patients was performed. Results: A total of 90 (10%) patients had a CT Scan as part of the initial workup.22 patients (24.4%) of the CT scan revealed malignancy. Among them, 18(60%) patients were diagnosed with primary colorectal tumors, and 4 (13%) patients had primary thoracic cancers. 8 (8.88%) showed metastatic disease on the scan. Among them, three (38%) were due to colorectal primary disease, and the remaining were diagnosed with widespread metastatic disease of unknown origin. The remaining patients were diagnosed with High grade B cell lymphoma, neuroendocrine tumor, pancreatic mass, and primary renal cell carcinoma. One patient had high grade small bowel obstruction due to a band adhesion resulting in emergency surgery and 5% of the patient needed a vascular referral for Abdominal aneurysm. Conclusion: CT scans in two-week colorectal referral patients play a significant role in the diagnosis of advanced disease. The ease of the procedure makes it more attractive during the pandemic in contrast to endoscopy and virtual colonoscopy, which have been significantly impacted by COVID 19.

A Price Worth Paying: Hodgkin’s Lymphoma in a Crohn’s Disease Patient Treated with Azathioprine and Infliximab

Fatma F. Elmijbri — 2024-04-21

Malignancy in patients with inflammatory bowel disease (IBD) is ranked second behind cardiovascular diseases as the leading cause of death. People with IBD are prone to develop a variety of extraintestinal malignancies, particularly lymphomas. Many of these malignancies are non-Hodgkin lymphomas (NHL). Hodgkin lymphoma (HL) is a rather uncommon lymphoproliferative condition to occur in IBD. To date, there have been just a few cases of HL in IBD patients reported in the literature. Modern treatment regimen for Crohn’s disease (CD) has helped prevent enterectomy, intestinal perforation, or stenosis. Thiopurine is a proven maintenance therapy for CD, while tumour necrosis factor (TNF) inhibitors are effective for remission induction and maintenance treatment. Despite the increased likelihood of malignancy associated with treating CD with these agents, the risk is worth the complications. As these patients require long-term treatment to keep the disease at bay. Here we report a case of HL developing in a patient with CD being treated with both azathioprine and infliximab. The occurrence of HL in IBD patients should be considered a complication to therapy, especially if they are subjected to long-term treatment with these agents.

Open Abdomen Is the Equal of Catastrophic or Hostile?

Lupio García Baruj Ricardo — 2024-04-21

Introduction: the aggression that represents a surgical event for whatever reason, entails consequences or sequelae that are sometimes devastating, for the patient and the health system itself. Objective: to describe the experience of open abdomen during 7 years of management, in the health system in Mexico. Method: study with a retrospective, longitudinal, observational, and descriptive design in the Surgery Service, multicenter study of four second and third level health care hospitals. Results: records of a total of 385 patients are reviewed, of which 234 are men (61%) and 151 are women (39%). With an age range from 17 years to 93 years. Patients potentially undergoing open abdomen management were classified into three groups. The overall adjusted mortality was 5 patients, which represents 1.29% of the total study. It culminated in the result of 5 cases with catastrophic abdomen and 3 patients with hostile abdomen. Discussion: the question is, what is the surgical indication for leaving the patient's abdomen open? Abdominal hypertension, abdominal sepsis, and damage control surgery, in trauma surgery, which is why it is specified and classified into open abdomen, catastrophic abdomen and hostile abdomen. Conclusion: Strategies must be taken to avoid at all costs the open abdomen and therefore its complications, considering the surgical findings, the surgeon's expertise, material, and human resources and/or infrastructure.

Orthopedic Patients and Use of Complementary and Alternative Medicine in Port Harcourt, Nigeria

Friday E. Aaron — 2024-04-21

Background: The use of Complementary and Alternative Medicine (CAM) is a global phenomenon with increasing popularity. This study evaluated the use of complementary and alternative medicine (CAM) among orthopaedic patients for proportion, types and reasons for usage in Port Harcourt, Nigeria in the last quarter of the year 2022. Materials and Methods: A descriptive and cross-sectional study was carried out among orthopedic patients in two Teaching Hospitals, using interviewer-administered questionnaire. Statistical analysis was done using IBM SPSS (Version.23.0). Results: The respondents’ mean age was 36.3±6.30 years. There were 245 (51%) males and 240 (49%) females, and more than half had at least a secondary education. Sixty percent of Orthopedic patients actively used CAM products. The most commonly used in decreasing order of frequency were prayers in religious houses (n = 290, 60%), honey and its products (n = 199, 41%), ginger extract (n = 192, 39%), traditional/oriental massage (n = 184, 38%), garlic extract (n = 170, 35%), and herbal medications (n = 170, 35%). The most common reasons for usage of CAM were lack of money/modern medicine expenses (n = 315, 65%), ineffectiveness of modern medicine 242(50%); to promote hospital effort for quick relief (n = 331, 68%); and to promote and maintain health (334, 69%). Conclusion: Type of CAM products in “current” use in order of decreasing frequency, were religious mind/body interventions, biological based therapy, and traditional/oriental massage. Multiple reasons were given for CAM usage. Formal public enlightenment and regulation bby government agencies is highly recommended.

Literature Review and Treatment Approach with Commonly Used Ayurveda and Traditional Decoctions for Kampavata (Parkinson's Disease)

H. G. S. P. Hewageegana — 2024-04-21

Kampavata is included in Vataja Nanatmaja Vikara (endogenous diseases caused by only one dosha), also known as Vepathuvata, explained by Acharya Charaka in Charaka Samhita, Sutrasthana, 20^th chapter. It is a considerable problem in the ageing society because they face Dhatu kshaya conditions (body tissues are not neutralising properly, and as a result, Vata and Kapha dosha are gradually being vitiated). Samprapti of Kampavata develops with Srotorodha (Sanga) or by Dhatu kshaya inside the brain. Sometimes, family history causes the Kampavata disease. This study aims to assess the pharmacodynamic properties of commonly used herbal decoctions for Vata vyadhi, compelling individuals to adopt them to correct the pathology and alleviate the symptoms of the disease. Consequently, Maharasnadi Kashaya, Arkananthadi Kashaya, Punarnawa Kashaya, Dashamula Mruthairanda Kashaya, Brahmimundi Kashaya, Gandarvahasthadi Kashaya, Prasarinyadi Kashaya, Mashatmagupthadi Kashaya were identified as suitable decoctions to prescribe in the pathological conditions such as Srotorodha (Sanga) or Dhatu kshaya. Gandarvahasthadi Kashaya, Mashatmaguptadi Kahsaya, Maharasnadi Kashaya, Arkananthadi Kashaya, Punarnawa Kashaya, Dashamulamruthairanda Kashaya, Brahmimundi Kashaya and Prasarinvadi Kashaya can be used to reduce the symptoms such as Kampa (tremor), Sthambha (stiffness), Vag vikruti (Speech disorder) and night-time urination (nocturia) and Vit vibandhata (constipation). Accordingly, the most suitable decoctions can be applied to the sickness to get more positive results on a scientific basis through Ayurveda Chikitsa.

Involvement of Nitric Oxide in Mitochondrial Activity and Brain Functions

Avraham Mayevsky — 2024-04-21

Nitric Oxide (NO) is a critical regulator of cerebral blood flow as well as in the activity of the respiratory chain in the normal brain. The reduction of nitrate by red blood cells producing NO, plays a role in the regulation of vascular tone. In our study we found that Nitrite infusion increases CBF and decreased m ean arterial pressure. In our study we found that Nitrite has a regulatory role in brain circulation but not in the small intestine. Also, it seems that NO plays an important role in the autoregulation of CBF and mitochondrial function in the partially ischemic brain. Also it was found that NOS inhibitors demonstrate a beneficial on the brain cortex under status epilepticus induced by metrazol, implying that they may serve as anticonvulsant drugs. In the current study we concluded that NO may play a role during the initial phase of cortical spreading depression namely during the depolarization phase.